Phenolic contents, antimicrobial and antioxidant activity of Olea ferruginea Royle (Oleaceae)
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BACKGROUND: Olea ferruginea Royle (Oleaceae) has long been used as an important ethnomedicinal plant to cure fever and debility, toothache, hoarseness, throatache and skeleton disorders. In this study, phenolic contents, antimicrobial and antioxidant activities of leaf and bark extracts (chloroform, ethanol and methanol) of O. ferruginea were evaluated. METHODS: Total phenolic contents were determined by Folin-Ciocalteu Spectrophotometric method. Antimicrobial activity was examined against Bacillus subtilis and Staphylococcus aureus (Gram positive), Escherichia coli (Gram negative), Candida albicans and Sccharomyces cerevisiae (yeas strains) by disc diffusion method. Antioxidant activity was observed through DPPH assay. RESULTS: The higher phenolic content was found in bark extract (376 μg/mg) of O. ferruginea. Chloroform extracts was found inactive against tested microorganisms while ethanol and methanol extracts showed pronounced inhibitory activity against both gram positive and gram negative bacteria. Only methanol extract of leaves inhibited the yeast strains. None of the bark extract inhibited the growth of tested yeast strains. The zones of inhibition formed by plant extracts were compared with zones of inhibition of available reference antibiotic discs such as tetracycline, ciprofloxacin and nystatin. Higher antioxidant activity was observed with methanol extracts of leaves and bark of O. ferruginea. CONCLUSION: These findings show that O. ferruginea has potential antimicrobial and antioxidant activities. This study suggests a possible application of olive leaves and bark as sources of natural antimicrobial and antioxidants.
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In mixed form, individual components can modify their properties and interact synergistically, producing improved effects.
“Additionally, in general, in the mixed form, individual components can modify their properties and interact synergistically, producing improved effects [18,25,39].”
From Comparison of Techniques and Solvents on the Antimicrobial and Antioxidant Potential of Extracts from Acacia dealbata and Olea europaea (2020) · cites this paper as [39]
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References 30 · Cited by 39
Research works printed but not linked: 2
- [3]Lanfranco G Invited review article on traditional medicine Electron J Biotechnol 1999 2 1 3
- [17]Steel RG, Torrie JH, Dickey DA. Principles and procedures of statistics: a biological approach. New York: McGraw-Hill; 1997.
- Authors
- Mehmood, A., & Murtaza, G.
- Affiliations
- University of Poonch Rawalakot (PK)
- University of Azad Jammu and Kashmir (PK)
- Corresponding author
- Mehmood, Ansar
- Venue
- BMC Complementary and Alternative Medicine
- Published
- 2018-06-05
- Volume
- 18
- Issue
- 1
- Pages
- 173-173
- ISSN
- 1472-6882 (ISSN-L)
- PMC
- PMC5987522
- OpenAlex
- W2807587196
- Cited by
- 39
- References
- 30
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 12 · 2022: 2 · 2021: 8 · 2020: 5 · 2019: 1
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- Olea ferruginea, phenolic content, antimicrobial activity, antioxidant activity, plant extracts, leaf extract, bark extract, methanol extract, ethanol extract, chloroform extract, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Candida albicans, Saccharomyces cerevisiae, ethnomedicinal plants, natural antimicrobials
- MeSH terms
- Anti-Bacterial Agents, Antioxidants, Bacteria, Fungi, Microbial Sensitivity Tests, Phenols, Plant Extracts, Plant Leaves, Plant Bark, Olea
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