Pharmacological properties of Centella asiatica hydrogel in accelerating wound healing in rabbits
Open accessAbstract
BACKGROUND: Various extracts of Centella asiatica (Apiaceae) and its active constituent, asiaticoside, have been reported to possess wound healing property when assessed using various in vivo and in vitro models. In an attempt to develop a formulation with accelerated wound healing effect, the present study was performed to examine in vivo efficacy of asiaticoside-rich hydrogel formulation in rabbits. METHODS: Asiaticoside-rich fraction was prepared from C. asiatica aerial part and then incorporated into polyvinyl alcohol/polyethylene glycol (PVA/PEG) hydrogel. The hydrogel was subjected to wound healing investigation using the in vivo incision model. RESULTS: The results obtained demonstrated that: i) the hydrogel formulation did not cause any signs of irritation on the rabbits' skin and; ii) enhanced wound healing 15% faster than the commercial cream and > 40% faster than the untreated wounds. The skin healing process was seen in all wounds marked by formation of a thick epithelial layer, keratin, and moderate formation of granulation tissues, fibroblasts and collagen with no fibrinoid necrosis detected. CONCLUSION: The asiaticoside-rich hydrogel developed using the freeze-thaw method was effective in accelerating wound healing in rabbits.
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Delivery systems such as nanoencapsulation could be used to increase C. asiatica's wound healing properties, extending the areas that can be treated due to higher bioavailability and skin penetration.
“Delivery systems such as nanoencapsulation could be used to increase C. asiatica’s wound healing properties, extending the areas that can be treated due to its higher bioavailability [46] and penetration through the skin [54].”
From A systematic review of the effect of Centella asiatica on wound healing (2022) · cites this paper as [54]
Citation [54] is attached specifically to the claim about penetration through the skin. The Results (Incisional wound healing; page unavailable) report improved healing with a C. asiatica hydrogel, but our copy does not address skin penetration; searches for “penetration” and “skin penetration” found no supporting passage. The bioavailability claim is attached to a different citation. (LLM, conf=0.76)
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References 29 · Cited by 88
Research works printed but not linked: 2
- [13]Stojadinovic A Carlson JW Schultz GS Davis TA Elster EA Topical advances in wound care Gynecol Oncol 2008 111 S70 S80 18793796
- [29]OECD. OECD Guideline for Testing of Chemicals: Acute Dermal Irritation/Corrosion 404, 2015. Retrieved July 7, 2019. https://www.oecd-ilibrary.org/docserver/9789264242678-en.pdf?expires=1562471325&id=id&accname=guest&checksum=AC98959151EA737460A13F0D6871ACAA
- Authors
- Sh. Ahmed, A., Taher, M., Mandal, U. K., Jaffri, J. M., Susanti, D., Mahmood, S., & Zakaria, Z. A.
- Affiliations
- International Islamic University Malaysia (MY)
- Maharaja Ranjit Singh Punjab Technical University (IN)
- Universiti Malaysia Pahang Al-Sultan Abdullah (MY)
- Universiti Putra Malaysia (MY)
- Corresponding author
- Taher, Muhammad
- Zakaria, Zainul Amiruddin
- Venue
- BMC Complementary and Alternative Medicine
- Published
- 2019-08-14
- Volume
- 19
- Issue
- 1
- Pages
- 213-213
- ISSN
- 1472-6882 (ISSN-L)
- PMC
- PMC6693193
- OpenAlex
- W2967186907
- Cited by
- 88
- References
- 29
- Citations by year
- 2026: 6 · 2025: 11 · 2024: 12 · 2023: 17 · 2022: 18 · 2021: 15 · 2020: 8 · 2019: 1
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- BMC Complementary and Alternative Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- The International Islamic University Malaysia Repository (The International Islamic University Malaysia) (acceptedVersion)
- Universiti Putra Malaysia Institutional Repository (Universiti Putra Malaysia) (acceptedVersion)
- UMP Institutional Repository (Universiti Malaysia Pahang) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Ministry of Higher Education, Malaysia (Incentive Research Grant Scheme (MIRGS), project no. MIRGS13-01-001-0006)
- Topics
- Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- Centella asiatica, asiaticoside, wound healing, hydrogel formulation, incision wound model, skin irritation, granulation tissue, collagen synthesis, freeze-thaw method, topical herbal medicine
- MeSH terms
- Animals, Humans, Male, Plant Extracts, Rabbits, Triterpenes, Wound Healing, Wounds and Injuries, Hydrogels, Centella
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