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Cited by 123Epilepsy research and treatmentVeterinary Orthopedics and NeurologyHuman-Animal Interaction Studies

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International Veterinary Epilepsy Task Force’s current understanding of idiopathic epilepsy of genetic or suspected genetic origin in purebred dogs

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Hülsmeyer, Velia-Isabel, Fischer, Andrea, Mandigers, Paul J.J., DeRisio, Luisa, Berendt, Mette, Rusbridge, Clare, Bhatti, Sofie F.M., Pakozdy, Akos, Patterson, Edward E., Platt, Simon, Packer, Rowena M.A., Volk, Holger A.·2015·BMC Veterinary Research
DOI 10.1186/s12917-015-0463-0PMC PMC4552344
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Abstract

Canine idiopathic epilepsy is a common neurological disease affecting both purebred and crossbred dogs. Various breed-specific cohort, epidemiological and genetic studies have been conducted to date, which all improved our knowledge and general understanding of canine idiopathic epilepsy, and in particular our knowledge of those breeds studied. However, these studies also frequently revealed differences between the investigated breeds with respect to clinical features, inheritance and prevalence rates. Awareness and observation of breed-specific differences is important for successful management of the dog with epilepsy in everyday clinical practice and furthermore may promote canine epilepsy research. The following manuscript reviews the evidence available for breeds which have been identified as being predisposed to idiopathic epilepsy with a proven or suspected genetic background, and highlights different breed specific clinical features (e.g. age at onset, sex, seizure type), treatment response, prevalence rates and proposed inheritance reported in the literature. In addition, certain breed-specific diseases that may act as potential differentials for idiopathic epilepsy are highlighted.

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  • The Cavalier King Charles Spaniel is susceptible to various neurological conditions linked to the shape of its skull.

    “One of the most frequently observed conditions among these is Chiari-like malformation/syringomyelia in the Cavalier King Charles Spaniel. This breed is also susceptible to various neurological conditions, such as fly catching [90], idiopathic epilepsy [91], idiopathic facial nerve paralysis with or without associated vestibular disease [92], and degenerative myelopathy [82], all of which are”

    From Ethical Concerns about Fashionable Dog Breeding (2024) · cites this paper as [91]

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Metadata

Authors
Hülsmeyer, V.-I., Fischer, A., Mandigers, P. J. J., DeRisio, L., Berendt, M., Rusbridge, C., Bhatti, S. F. M., Pakozdy, A., Patterson, E. E., Platt, S., Packer, R. M. A., & Volk, H. A.
Affiliations
  • Ludwig-Maximilians-Universität München (DE)
  • Utrecht University (NL)
  • University of Copenhagen (DK)
  • University of Surrey (GB)
  • Ghent University (BE)
  • University of Minnesota (US)
  • University of Georgia (US)
  • Royal Veterinary College (GB)
Corresponding author
Hülsmeyer, Velia-Isabel
ORCID
Venue
BMC Veterinary Research
Publisher
Springer Science and Business Media LLC
Published
2015-08-28
Volume
11
Issue
1
Pages
175-175
ISSN
1746-6148 (ISSN-L)
DOI
10.1186/s12917-015-0463-0
PMC
PMC4552344
OpenAlex
W1905138928
Cited by
123
References
0
Citations by year
2026: 12 · 2025: 11 · 2024: 18 · 2023: 20 · 2022: 13 · 2021: 7 · 2020: 11 · 2019: 6 · 2018: 8 · 2017: 6 · 2016: 8 · 2015: 2
FWCI
6.50
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Veterinary Research (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, other-oa)
  • Ghent University Academic Bibliography (Ghent University) (submittedVersion, other-oa)
  • RVC Research Online (Royal Veterinary College) (submittedVersion, cc-by)
  • Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
  • Open access LMU (Ludwid Maxmilian's Universitat Munchen) (submittedVersion)
  • Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
Funders
Royal Veterinary College
Topics
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Health Sciences › Veterinary › Small Animals › Veterinary Orthopedics and Neurology
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
Keywords
canine idiopathic epilepsy, purebred dogs, genetic susceptibility, heredity (biology), epilepsy prevalence, seizure types, age of onset, sex differences, treatment response, differential diagnosis, epilepsy management
MeSH terms
Aging, Animals, Breeding, Dog Diseases, Dogs, Epilepsy, Female, Male, Sex Factors, Veterinary Medicine, Genetic Predisposition to Disease, Internationality

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