The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Effects of 6-month treatment with the glucagon like peptide-1 analogue liraglutide on arterial stiffness, left ventricular myocardial deformation and oxidative stress in subjects with newly diagnosed type 2 diabetes
Open accessAbstract
Abstract Background Incretin-based therapies are used in the treatment of type 2 diabetes mellitus (T2DM) and obesity. We investigated the changes in arterial stiffness and left ventricular (LV) myocardial deformation after 6-month treatment with the GLP-1 analogue liraglutide in subjects with newly diagnosed T2DM. Methods We randomized 60 patients with newly diagnosed and treatment-naive T2DM to receive either liraglutide (n = 30) or metformin (n = 30) for 6 months. We measured at baseline and after 6-month treatment: (a) carotid-femoral pulse wave velocity (PWV) (b) LV longitudinal strain (GLS), and strain rate (GLSR), peak twisting (pTw), peak twisting velocity (pTwVel) and peak untwisting velocity (pUtwVel) using speckle tracking echocardiography. LV untwisting was calculated as the percentage difference between peak twisting and untwisting at MVO (%dpTw–UtwMVO), at peak (%dpTw–UtwPEF) and end of early LV diastolic filling (%dpTw–UtwEDF) (c) Flow mediated dilatation (FMD) of the brachial artery and percentage difference of FMD (FMD%) (d) malondialdehyde (MDA), protein carbonyls (PCs) and NT-proBNP. Results After 6-months treatment, subjects that received liraglutide presented with a reduced PWV (11.8 ± 2.5 vs. 10.3 ± 3.3 m/s), MDA (0.92 [0.45–2.45] vs. 0.68 [0.43–2.08] nM/L) and NT-proBNP (p < 0.05) in parallel with an increase in GLS (− 15.4 ± 3 vs. − 16.6 ± 2.7), GLSR (0.77 ± 0.2 vs. 0.89 ± 0.2), pUtwVel (− 97 ± 49 vs. − 112 ± 52°, p < 0.05), %dpTw–UtwMVO (31 ± 10 vs. 40 ± 14), %dpTw–UtwPEF (43 ± 19 vs. 53 ± 22) and FMD% (8.9 ± 3 vs. 13.2 ± 6, p < 0.01). There were no statistically significant differences of the measured markers in subjects that received metformin except for an improvement in FMD. In all subjects, PCs levels at baseline were negatively related to the difference of GLS (r = − 0.53) post-treatment and the difference of MDA was associated with the difference of PWV (r = 0.52) (p < 0.05 for all associations) after 6-month treatment. Conclusions Six-month treatment with liraglutide improves arterial stiffness, LV myocardial strain, LV twisting and untwisting and NT-proBNP by reducing oxidative stress in subjects with newly diagnosed T2DM. ClinicalTrials.gov Identifier NCT03010683
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Similarly, evidence for oxidative stress markers like MDA is promising but varied, with some trials showing clear superiority of GLP-1 RAs over insulin or metformin (9, 21, 22).”
In the citing paper
“In mechanistic studies, GLP-1RAs were shown to improve cardiac function in patients with T2DM.”
From The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF (2023) · cites this paper as [46]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
2013 ESH/ESC Guidelines for the management of arterial hypertension
Authors Task Force Members, Mancia, G., Fagard, R., Narkiewicz, K., Redon, J., Zanchetti, A., Böhm, M., Christiaens, T., Cífková, R., Backer, G. D., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht151 · Cited by 13,728
Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2014.10.003 · Cited by 12,362
Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes
Zinman, B., Wanner, C., Lachin, J. M., Fitchett, D., Bluhmki, E., Hantel, S., Mattheus, M., Devins, T., Johansen, O. E., Woerle, H. J., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504720 · Cited by 12,315
Lang, R. M., Badano, L. P., Mor‐Avi, V., Afilalo, J., Armstrong, A. D. C., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jev014 · Cited by 8,583
Liraglutide and Cardiovascular Outcomes in Type 2 Diabetes
Marso, S. P., Daniels, G. H., Brown-Frandsen, K., Kristensen, P., Mann, J. F. E., Nauck, M. A., Nissen, S. E., Pocock, S., Poulter, N. R., Ravn, L. S., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603827 · Cited by 7,629
[49] Determination of carbonyl content in oxidatively modified proteins
Levine, R. L., Garland, D. L., Oliver, C. N., Amici, A., Climent, I., Lenz, A.-G., Ahn, B. W., Shaltiel, S., & Stadtman, E. R. (1990) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(90)86141-h · Cited by 5,895
The Physiology of Glucagon-like Peptide 1
Holst, J. J. (2007) · Physiological Reviews · doi:10.1152/physrev.00034.2006 · Cited by 3,371
Diabetes, oxidative stress, and antioxidants: A review
Maritim, A. C., Sanders, R. A., & Watkins, J. B. (2003) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.10058 · Cited by 3,167
The biology of incretin hormones
Drucker, D. J. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.004 · Cited by 2,210
Authors Task Force Members, Rydén, L., Grant, P. J., Anker, S. D., Berne, C., Cosentino, F., Danchin, N., Deaton, C., Escaned, J., Hammes, H., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht108 · Cited by 1,987
Cited by
Sorted by citations
Tan, Y., Zhang, Z., Zheng, C., Wintergerst, K. A., Keller, B. B., & Cai, L. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-0339-2 · Cited by 855
Ikonomidis, I., Aboyans, V., Blacher, J., Brodmann, M., Brutsaert, D. L., Chirinos, J. A., Carlo, M. D., Delgado, V., Lancellotti, P., Lekakis, J. P., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1436 · Cited by 396
Self-citationDiabesity: the combined burden of obesity and diabetes on heart disease and the role of imaging
Ng, A. C. T., Delgado, V., Borlaug, B. A., & Bax, J. J. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00465-5 · Cited by 350
Concept of Extremes in Vascular Aging
Laurent, S., Boutouyrie, P., Cunha, P., Lacolley, P. J., & Nilsson, P. M. (2019) · Hypertension · doi:10.1161/hypertensionaha.119.12655 · Cited by 232
Withaar, C., Meems, L. M. G., Markousis-Mavrogenis, G., Boogerd, C. J., Silljé, H. H. W., Schouten, E. M., Dokter, M. M., Voors, A. A., Westenbrink, B. D., Lam, C. S. P., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvaa256 · Cited by 223
Ikonomidis, I., Pavlidis, G., Thymis, J., Birba, D., Kalogeris, A., Kousathana, F., Kountouri, A., Balampanis, K., Parissis, J., Andreadou, I., et al. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.015716 · Cited by 199
Self-citationBray, J. J. H., Foster‐Davies, H., Salem, A., Hoole, A. L., Obaid, D. R., Halcox, J. P. J., & Stephens, J. W. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14399 · Cited by 194
Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis
Fei, Y., Tsoi, M. F., & Cheung, B. M. Y. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0916-z · Cited by 159
Centrally Acting Agents for Obesity: Past, Present, and Future
Coulter, A. A., Rebello, C. J., & Greenway, F. L. (2018) · Drugs · doi:10.1007/s40265-018-0946-y · Cited by 151
Bednarz, K., Kowalczyk, K., Cwynar, M., Czapla, D., Czarkowski, W., Kmita, D., Nowak, A., & Madej, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084334 · Cited by 148
Batzias, K., Antonopoulos, A. S., Oikonomou, E. K., Siasos, G., Bletsa, E., Stampouloglou, P. K., Mistakidi, C. V., Noutsou, M., Katsiki, N., Karopoulos, P., et al. (2018) · Journal of Diabetes Research · doi:10.1155/2018/1232583 · Cited by 142
Vascular ageing: moving from bench towards bedside
Climie, R. E., Alastruey, J., Mayer, C. C., Schwarz, A., Laučytė-Cibulskienė, A., Voicehovska, J., Bianchini, E., Bruno, R. M., Charlton, P. H., Grillo, A., et al. (2023) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwad028 · Cited by 149
Bizino, M. B., Jazet, I. M., Westenberg, J. J. M., van Eyk, H. J., Paiman, E. H. M., Smit, J. W. A., & Lamb, H. J. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0857-6 · Cited by 137
Diabetic cardiomyopathy: Clinical phenotype and practice
Zhao, X., Liu, S., Wang, X., Chen, Y., Pang, P., Yang, Q., Lin, J., Deng, S., Shen-tao, W., Fan, G., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1032268 · Cited by 127
Markus, M. R. P., Rospleszcz, S., Ittermann, T., Baumeister, S. E., Schipf, S., Siewert‐Markus, U., Lorbeer, R., Storz, C., Ptushkina, V., Peters, A., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0948-4 · Cited by 120
Luna-Marco, C., Iannantuoni, F., Hermo-Argibay, A., Devos, D., Salazar, J. D., Víctor, V. M., & Rovira-Llopis, S. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.01.015 · Cited by 114
Bain, S. C., Mosenzon, O., Arechavaleta, R., Bogdański, P., Çömlekçi, A., Consoli, A., Deerochanawong, C., Dungan, K. M., Faingold, M. C., Farkouh, M. E., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13553 · Cited by 100
Lunder, M., Janić, M., Japelj, M., Juretič, A., Janež, A., & Šabović, M. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0797-6 · Cited by 100
Horton, W. B., Love, K. M., Gregory, J. M., Liu, Z., & Barrett, E. J. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00826.2024 · Cited by 93
Role of Oxidative Stress in Metabolic and Subcellular Abnormalities in Diabetic Cardiomyopathy
Dhalla, N. S., Shah, A. K., & Tappia, P. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072413 · Cited by 78
for the Relationship between Cardiovascular disease and Brachial-ankle Pulse Wave Velocity (baPWV) in Patients with Type 2 Diabetes (REBOUND) Study Group, Kim, J. M., Kim, S. S., Kim, I. J., Kim, J. H., Kim, B. H., Kim, M.-K., Lee, S. H., Lee, C. W., Kim, M. C., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01120-6 · Cited by 78
The cardioprotective effects of semaglutide exceed those of dietary weight loss in mice with HFpEF
Withaar, C., Meems, L. M. G., Nollet, E. E., Schouten, E. M., Schroeder, M. A., Knudsen, L. B., Niss, K., Madsen, C. T., Hoegl, A., Mazzoni, G., et al. (2023) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2023.05.012 · Cited by 74
Wang, N., Tan, A. W. K., Jahn, L. A., Hartline, L. M., Patrie, J. T., Lin, S., Barrett, E. J., Aylor, K. W., & Liu, Z. (2019) · Diabetes Care · doi:10.2337/dc19-1465 · Cited by 73
Natali, A., Nesti, L., Tricò, D., & Ferrannini, E. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-021-01385-5 · Cited by 70
Tuttolomondo, A., Cirrincione, A., Casuccio, A., Cuore, A. D., Daidone, M., Chiara, T. D., Raimondo, D. D., Corte, V. D., Maida, C. D., Simonetta, I., et al. (2021) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01183-5 · Cited by 70
Vascular Aging and Disease of the Large Vessels: Role of Inflammation
Maloberti, A., Vallerio, P., Triglione, N., Occhi, L., Panzeri, F., Bassi, I., Pansera, F., Piccinelli, E., Peretti, A., Garatti, L., et al. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00318-4 · Cited by 68
Zhang, D.-P., Xu, L., Wang, L., Wang, H.-J., & Jiang, F. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-0987-x · Cited by 65
Metformin monotherapy for adults with type 2 diabetes mellitus
Gnesin, F., Thuesen, A. C. B., Kähler, L. K. A., Madsbad, S., & Hemmingsen, B. (2020) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012906.pub2 · Cited by 63
Rivera, F. B., Lumbang, G. N. O., Gaid, D. R. M., Cruz, L. L. A., Magalong, J. V., Bantayan, N. R. B., Lara-Breitinger, K. M., Gulati, M., & Bakris, G. L. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15529 · Cited by 59
Du, X., Zhang, H., Zhang, W., Wang, Q., Wang, W., Ge, G., Bai, J., Guo, X., Zhang, Y., Jiang, X., et al. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105732 · Cited by 55
Diabetes pathogenesis and management: the endothelium comes of age
Love, K. M., Barrett, E. J., Malin, S. K., Reusch, J. E. B., Regensteiner, J. G., & Liu, Z. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab024 · Cited by 55
Lee, M. M. Y., Petrie, M. C., McMurray, J. J. V., & Sattar, N. A. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.311904 · Cited by 57
Sukumaran, V., Tsuchimochi, H., Sonobe, T., Waddingham, M. T., Shirai, M., & Pearson, J. T. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01000-z · Cited by 53
Gut microbiota regulates cardiac ischemic tolerance and aortic stiffness in obesity
Battson, M. L., Lee, D. M., Puma, L. C. L., Ecton, K. E., Thomas, K. N., Febvre, H. P., Chicco, A. J., Weir, T. L., & Gentile, C. L. (2019) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00346.2019 · Cited by 51
Poon, A. K., Meyer, M. L., Tanaka, H., Selvin, E., Pankow, J. S., Zeng, D., Loehr, L. R., Knowles, J. W., Rosamond, W. D., & HEISS, G. M. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-0986-y · Cited by 46
Vascular aging and cardiovascular disease: pathophysiology and measurement in the coronary arteries
Cheng, D. C., Climie, R. E., Shu, M. W. S., Grieve, S. M., Kozor, R., & Figtree, G. A. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1206156 · Cited by 50
Lambadiari, V., Thymis, J., Kouretas, D., Skaperda, Z., Tekos, F., Kousathana, F., Kountouri, A., Balampanis, K., Parissis, J., Andreadou, I., et al. (2021) · Antioxidants · doi:10.3390/antiox10091379 · Cited by 42
“MDA was estimated spectrophotometrically with a commercial kit (Oxford Biomedical Research, Rochester Hills, MI, USA) of colorimetric assay for lipid peroxidation (measurements range, 1–20 nmol/L) with a previously described methodology [37].”
MethodResultSelf-citationPaiman, E. H. M., van Eyk, H. J., van Aalst, M., Bizino, M. B., van der Geest, R. J., Westenberg, J. J. M., Geelhoed-Duijvestijn, P. H. L. M., Kharagjitsingh, A. V., Rensen, P. C. N., Smit, J. W. A., et al. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27009 · Cited by 42
Arterial Stiffness and Heart Failure With Preserved Ejection Fraction
Kim, H., & Jo, S. (2024) · Journal of Korean Medical Science · doi:10.3346/jkms.2024.39.e195 · Cited by 43
Love, K. M., Liu, J., Regensteiner, J. G., Reusch, J. E. B., & Liu, Z. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13045 · Cited by 40
Zheng, C., Zhou, M., Sun, J., Xiong, H., Peng, P., Gu, Z., & Deng, Y. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2019.06.001 · Cited by 40
Mashayekhi, M., Beckman, J. A., Nian, H., Garner, E. M., Mayfield, D., Wright, P., Howard, S. E., Perkins, B., Olson, D., Snyder, W. E., et al. (2022) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14903 · Cited by 43
GLP-1 Receptor Agonists and Myocardial Perfusion: Bridging Mechanisms to Clinical Outcomes
Karakasis, P., Patoulias, D., Theofilis, P., Pamporis, K., Sagris, Μ., Vlachakis, P. K., Koufakis, T., Antoniadis, A. P., & Fragakis, N. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073050 · Cited by 38
Moreno, B. V. D., de Faria, A. P., Ritter, A. M. V., Yugar, L. B. T., Ferreira‐Melo, S. E., de Amorim, R. F. B., Modolo, R., Fattori, A., Yugar‐Toledo, J. C., Coca, A., et al. (2018) · Journal of Clinical Hypertension · doi:10.1111/jch.13293 · Cited by 33
Pharmacological modulation of vascular ageing: A review from VascAgeNet
Roth, L., Doğan, S., Tuna, B. G., Arányi, T., Benı́tez, S., Borrell-Pagés, M., Bozaykut, P., Meyer, G. R. Y. D., Duca, L., Durmuş, N., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102122 · Cited by 38
Gao, L., Li, S., & Li, Y. (2018) · DNA and Cell Biology · doi:10.1089/dna.2018.4397 · Cited by 33
Lambadiari, V., Pavlidis, G., Kousathana, F., Maratou, E., Georgiou, D., Andreadou, I., Kountouri, A., Varoudi, M., Balampanis, K., Parissis, J., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070983 · Cited by 33
Self-citationTsikas, D., Tsikas, S. A., Mikuteit, M., & Ückert, S. (2023) · Biomedicines · doi:10.3390/biomedicines11102744 · Cited by 32
Bechlioulis, A., Markozannes, G., Chionidi, I., Liberopoulos, E. N., Naka, K. Κ., Ntzani, E., Liatis, S., Rizzo, M., & Rizos, E. C. (2023) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2023.108436 · Cited by 31
Ye, W., Han, K., Xie, M., Li, S., Chen, G., Wang, Y., & Li, T. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003075 · Cited by 32
Tanaka, A., & Node, K. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0731-y · Cited by 30
Endothelium as a Therapeutic Target in Diabetes Mellitus: From Basic Mechanisms to Clinical Practice
Tentolouris, A., Eleftheriadou, I., Tzeravini, E., Tsilingiris, D., Paschou, S. Α., Siasos, G., & Tentolouris, N. (2019) · Current Medicinal Chemistry · doi:10.2174/0929867326666190119154152 · Cited by 31
Larsen, E. L., Weimann, A., & Poulsen, H. E. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.09.030 · Cited by 30
Vernstrøm, L., Gullaksen, S., Sørensen, S. S., Funck, K. L., Laugesen, E., & Poulsen, P. L. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15464 · Cited by 30
Navodnik, M. P., Janež, A., & Žuran, I. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15071945 · Cited by 28
Wang, T., Ding, J., Cheng, X., Yang, Q., & Hu, P. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1396656 · Cited by 29
Avogaro, A., Azzolina, D., Gregori, D., de Kreutzenberg, S., Fadini, G. P., & Mannucci, E. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.03.032 · Cited by 27
King, N. E., & Brittain, E. L. (2022) · Pulmonary Circulation · doi:10.1002/pul2.12028 · Cited by 28
Diabesity in Elderly Cardiovascular Disease Patients: Mechanisms and Regulators
García‐Vega, D., González‐Juanatey, J. R., & Eirás, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147886 · Cited by 26
The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes
Sivalingam, S., Larsen, E. L., van Raalte, D. H., Muskiet, M. H. A., Smits, M. M., Tonneijck, L., Joles, J. A., von Scholten, B. J., Zobel, E. H., Persson, F., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90191-w · Cited by 23
Durak, A. T., Akkuş, E., Canpolat, A. G., Tuncay, E., Çorapçıoğlu, D., & Turan, B. (2021) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13590 · Cited by 22
New antidiabetic therapy and HFpEF: light at the end of tunnel?
Tadić, M., Sala, C., Saeed, S., Grassi, G. M., Mancia, G., Rottbauer, W., & Cuspidi, C. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10106-9 · Cited by 23
Zhang, Z., Wang, X., Yang, L., Yang, L., & Ma, H. (2021) · PubMed Central · doi:10.22038/ijbms.2021.56771.12677 · Cited by 22
Zhang, Y., Yang, D., Jia, Q., Yan, J., & An, F. (2024) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.15557 · Cited by 22
Rizos, E. C., Tagkas, C. F., Asimakopoulos, A., Tsimihodimos, V., Anastasiou, G., Rizzo, M., Agouridis, A. P., & Ntzani, E. (2024) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2024.108781 · Cited by 21
Wang, J., Wang, Y., Wang, Y., Li, Y., Zhang, J., Zhang, H., Fu, X., Guo, Z., Yang, Y., Kang, K., et al. (2023) · Journal of Diabetes · doi:10.1111/1753-0407.13405 · Cited by 20
Steven, S., Kuntić, M., Münzel, T. F., & Daiber, A. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100082 · Cited by 22
Cardiovascular Outcomes in Trials of New Antidiabetic Drug Classes
Lo, C. W. H., Fei, Y., & Cheung, B. M. Y. (2021) · Cardiac failure review · doi:10.15420/cfr.2020.19 · Cited by 19
Novel Insights Into the Pathogenesis of Diabetic Cardiomyopathy and Pharmacological Strategies
Muñoz‐Córdova, F., Hernández-Fuentes, C. P., López‐Crisosto, C., Troncoso, M. F., Calle, X., Guerrero‐Moncayo, A., Gabrielli, L., Chiong, M., Castro, P., & Lavandero, S. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.707336 · Cited by 19
Simeone, P., Tripaldi, R., Michelsen, A. E., Ueland, T., Liani, R., Ciotti, S., Birkeland, K. I., Gulseth, H. L., Castelnuovo, A. F. D., Cipollone, F., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01469-w · Cited by 22
Cardiac energy metabolism in diabetes: emerging therapeutic targets and clinical implications
Panwar, A., Malik, S. O., Adib, M., & Lopaschuk, G. D. (2025) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00615.2024 · Cited by 19
Treating Arterial Ageing in Patients with Diabetes: From Mechanisms to Effective Drugs
Lunder, M., Janić, M., & Šabović, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22062796 · Cited by 20
Korakas, E., Kountouri, A., Pavlidis, G., Oikonomou, E., Vrentzos, E., Michalopoulou, E., Tsigkou, V., Katogiannis, K., Pliouta, L., Balampanis, K., et al. (2024) · Journal of the Endocrine Society · doi:10.1210/jendso/bvae122 · Cited by 18
Self-citationYagi, K., Imamura, T., Tada, H., Chujo, D., Liu, J., Shima, Y., Ohbatake, A., Miyamoto, Y., Okazaki, S., Ito, N., et al. (2021) · Journal of Diabetes Research · doi:10.1155/2021/8838026 · Cited by 18
Varin, E. M., McLean, B. A., & Lovshin, J. A. (2019) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2019.08.011 · Cited by 17
Wang, Y., Yao, M., Wang, J., Liu, H., Zhang, X., Zhao, L., Hu, X., Guan, H., & Lyu, Z. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.818537 · Cited by 18
Huang, R., Mills, K., Romero, J., Li, Y., Hu, Z., Cao, Y., Huang, H., Xu, Y., & Jiang, L. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0817-1 · Cited by 18
Król, M., Kupnicka, P., Żychowska, J., Kapczuk, P., Szućko-Kociuba, I., Prajwos, E., & Chlubek, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26146777 · Cited by 18
The potential of glucagon-like peptide-1 receptor agonists in heart failure
Kreiner, F. F., Hovingh, G. K., & von Scholten, B. J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.983961 · Cited by 17
Basile, P., Guaricci, A. I., Piazzolla, G., Volpe, S., Vozza, A., Benedetto, M., Carella, M. C., Santoro, D., Monitillo, F., Baggiano, A., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041586 · Cited by 16
Ikonomidis, I., Katogiannis, K., Kyriakou, E. S., Taichert, M., Katsimaglis, G., Tsoumani, M. E., Andreadou, I., Maratou, E., Lambadiari, V., Kousathana, F., et al. (2020) · Journal of Thrombosis and Thrombolysis · doi:10.1007/s11239-020-02060-4 · Cited by 16
Self-citationGerstein, H. C., Lee, S.-F., Paré, G., Bethel, M. A., Colhoun, H. M., Hoover, A., Lakshmanan, M. C., Lin, Y., Pirro, V., Qian, H.-R., et al. (2023) · Diabetes Care · doi:10.2337/dc22-2397 · Cited by 17
Theofilis, P., Oikonomou, E. K., Lazaros, G. A., Vogiatzi, G., Anastasiou, Μ., Mystakidi, V. C., Goliopoulou, A., Christoforatou, E., Bourouki, E., Vavouranaki, G., et al. (2021) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2021.12.013 · Cited by 15
Diabetes mellitus therapy in the light of oxidative stress and cardiovascular complications
Osman, A. A. M., Seres, A. B., & Ducza, E. (2024) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2024.108941 · Cited by 14
Bojer, A. S., Sørensen, M. H., Bjerre, J., Gæde, P., Vejlstrup, N. G., & Madsen, P. L. (2021) · Diabetes Obesity and Metabolism · doi:10.1111/dom.14480 · Cited by 14
Ikonomidis, I., Pavlidis, G., Pliouta, L., Katogiannis, K., Maratou, E., Thymis, J., Michalopoulou, E., Prentza, V., Katsanaki, E., Vlachomitros, D., et al. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.039129 · Cited by 13
Self-citationLundgren, J. R., Færch, K., Witte, D. R., Jonsson, A. E., Pedersen, O. B., Hansen, T. F., Lauritzen, T., Holst, J. J., Vistisen, D., Jørgensen, M. E., et al. (2019) · Cardiovascular Diabetology · doi:10.1186/s12933-019-0937-7 · Cited by 13
COVID-19, Endothelium and the Cardiometabolic Patient: A Possible Role for Capillary Leak Syndrome
Lambadiari, V., Korakas, E., Oikonomou, E. K., Bletsa, E., Kountouri, A., Goliopoulou, A., Ikonomidis, I., & Siasos, G. (2022) · Biomedicines · doi:10.3390/biomedicines10102379 · Cited by 12
Self-citationFerdinand, K. C., Dunn, J. P., Nicolay, C., Sam, F., Blue, E. K., & Wang, H. (2023) · Cardiovascular Diabetology · doi:10.1186/s12933-023-01775-x · Cited by 13
Oxidative Stress and Antioxidant Therapy in Cardiovascular Diseases—Clinical Challenge
Pavlidis, G. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11133784 · Cited by 12
Self-citationOsumili, B., Sapin, H., Yang, Z., Ranta, K., Paik, J. S., & Blüher, M. (2025) · Diabetes Therapy · doi:10.1007/s13300-025-01728-5 · Cited by 12
Wei, H., Ye, L., Li, M., Huang, S., & Mo, Z. (2025) · Journal of the Endocrine Society · doi:10.1210/jendso/bvaf075 · Cited by 12
Tamura, H., Kondo, Y., Ito, K., Hasebe, M., Satoh, S., & Terauchi, Y. (2022) · PLoS ONE · doi:10.1371/journal.pone.0262831 · Cited by 11
Bosanac, J., Straus, L., Novaković, M., Košuta, D., Mijovski, M. B., Tasić, J., & Jug, B. (2022) · Disease Markers · doi:10.1155/2022/9539676 · Cited by 11
Changes in Left Ventricular Mechanics After Sleeve Gastrectomy
Santos, E. C. L., del Castillo, J. M., Parente, G. B., Pedrosa, R. P., Gadelha, P. S., Lópes, R. D., Kreimer, F., & Neto, F. R. M. (2019) · Obesity Surgery · doi:10.1007/s11695-019-04216-5 · Cited by 11
Potential of Glucagon-Like Peptide 1 as a Regulator of Impaired Cholesterol Metabolism in the Brain
Kim, Y., & Song, J. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa080 · Cited by 8
Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models
Bao, J., Gao, Z., Hu, Y., Ye, L., & Wang, L. (2023) · Channels · doi:10.1080/19336950.2023.2281743 · Cited by 9
Derobertmasure, A., Toh, L. S., Wotring, V. E., Williams, P. M., Morbidelli, L., Stingl, J., Vinken, M., Ramadan, R., Chhun, S., & Boutouyrie, P. (2025) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2025.107063 · Cited by 8
Turan, B., Durak, A. T., Olğar, Y., & Tuncay, E. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04474-5 · Cited by 8
Chee, Y. J., & Dalan, R. (2024) · Biomedicines · doi:10.3390/biomedicines12071386 · Cited by 7
Metadata
- Authors
- Lambadiari, V., Pavlidis, G., Kousathana, F., Varoudi, M., Vlastos, D., Maratou, E., Georgiou, D., Andreadou, I., Parissis, J., Triantafyllidi, H., Lekakis, J., Iliodromitis, E., Dimitriadis, G., & Ikonomidis, I.
- Affiliations
- National and Kapodistrian University of Athens (GR)
- Corresponding author
- Lambadiari, Vaia
- ORCID
- Venue
- Cardiovascular Diabetology
- Published
- 2018-01-08
- Volume
- 17
- Issue
- 1
- Pages
- 8-8
- ISSN
- 1475-2840 (ISSN-L)
- PMC
- PMC5759220
- OpenAlex
- W2782989965
- Cited by
- 146
- References
- 52
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 16 · 2022: 17 · 2021: 22 · 2020: 21 · 2019: 22 · 2018: 7
- FWCI
- 14.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cardiovascular Diabetology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- liraglutide, GLP-1 receptor agonists, type 2 diabetes, newly diagnosed diabetes, arterial stiffness, left ventricular myocardial deformation, oxidative stress, metformin, pulse wave velocity, flow-mediated dilation, malondialdehyde, protein carbonyls, NT-proBNP, speckle tracking echocardiography
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Liraglutide, Glucagon-Like Peptide-1 Receptor Agonists, Adult, Biomechanical Phenomena, Diabetes Mellitus, Type 2, Diabetic Angiopathies, Female, Greece, Humans, Hypoglycemic Agents, Male, Middle Aged, Myocardial Contraction, Peptide Fragments, Time Factors, Biomarkers, Ventricular Function, Left, Treatment Outcome, Oxidative Stress, Natriuretic Peptide, Brain, Incretins, Diabetic Cardiomyopathies, Vascular Stiffness
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
