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Cited by 19Effects and risks of endocrine disrupting chemicalsToxic Organic Pollutants ImpactHealth, Environment, Cognitive Aging

The DOI matches its Crossref record; 208 of the 208 references it cites were found in a registry or an index.

Endocrine-disrupting chemicals exposure: cardiometabolic health risk in humans

Open access
Ma, Cheng-Xu, Ma, Xiao-Ni, Li, Hong-Li, Mauricio, Dídac, Fu, Song-Bo·2025·Cardiovascular Diabetology
DOI 10.1186/s12933-025-02938-8PMC PMC12487381
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Abstract

Endocrine-disrupting chemicals (EDCs) are exogenous compounds that interfere with hormone action, and growing evidence suggests that human exposure to certain EDCs may increase the risk of obesity, type 2 diabetes mellitus (T2DM), and cardiovascular disease (CVD). To clarify the impact of EDC exposure on cardiometabolic health, we conducted a review of the literature (2005-2025) to identify both human epidemiological studies and animal mechanistic studies. In this narrative review, we primarily summarize the existing human epidemiological evidence on the cardiometabolic effects of EDCs, while also considering mechanistic insights, including selected animal studies, to illustrate biological plausibility. Key findings indicate that EDC exposures are consistently associated with elevated risks of cardiometabolic conditions. Notably, prenatal and early-life EDC exposures appear to increase susceptibility to obesity, impaired glucose metabolism, and cardiovascular dysfunction later in life, while adult exposures are linked to a higher incidence of metabolic syndrome, type 2 diabetes, and related cardiovascular complications. In conclusion, this review underscores EDC exposure as a significant environmental risk factor for cardiometabolic disease. Accordingly, strengthening regulatory policies to reduce human exposure to these chemicals-alongside further research into underlying mechanisms-may be crucial for improving cardiometabolic health outcomes.

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Fig. 1 Common EDCs, their source, and exposure routes. Figure created in https://BioRender.com. Abbreviations: DDE, dichlorodiphenyldichloroethylene; DDT, dichlorodiphenyltrichloroethane; HBCD, hexabromocyclododecane; PAH, polycyclic aromatic hydrocarbons; PBDE, polybrominated diphenyl ethers; PFAS, per- and polyfluoroalkyl substances; TBBPA, tetrabromobisphenol A; TBBPS, tetrabromobisphenol S; TCEP, tris(2-chloroethyl) phosphate; TDCPP, tris(1,3-dichloro-2-propyl) phosphate
Fig. 1 Common EDCs, their source, and exposure routes. Figure created in https://BioRender.com. Abbreviations: DDE, dichlorodiphenyldichloroethylene; DDT, dichlorodiphenyltrichloroethane; HBCD, hexabromocyclododecane; PAH, polycyclic aromatic hydrocarbons; PBDE, polybrominated diphenyl ethers; PFAS, per- and polyfluoroalkyl substances; TBBPA, tetrabromobisphenol A; TBBPS, tetrabromobisphenol S; TCEP, tris(2-chloroethyl) phosphate; TDCPP, tris(1,3-dichloro-2-propyl) phosphateCC BY-NC-ND · PubMed Central
Fig. 2 Pathogenic mechanisms of EDCs in cardiometabolic disease. BPA, Bisphenol A; PFAS, per- and polyfluoroalkyl substances
Fig. 2 Pathogenic mechanisms of EDCs in cardiometabolic disease. BPA, Bisphenol A; PFAS, per- and polyfluoroalkyl substancesCC BY-NC-ND · PubMed Central

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  1. Zangiabadian M, Jolfayi AG, Nejadghaderi SA, Amirkhosravi L, Sanjari M. The association between heavy metal exposure and obesity: a systematic review and meta-analysis. J Diabet Metabolic Disorders. 2024;23(1):11–26. · DOI
  2. Mohd Efendy Goon MD, Zulkifli S, Abdullah Soheimi SS, Ab Rahim S, Abd Latip N, Hashim N, et al. Association between polychlorinated biphenyl (PCB) and dioxin with metabolic syndrome (METS): a systematic review and meta-analysis. Sci Rep. 2024;14(1):17941. · DOI

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Metadata

Authors
Ma, C.-X., Ma, X.-N., Li, H.-L., Mauricio, D., & Fu, S.-B.
Venue
Cardiovascular Diabetology
Publisher
Springer Science and Business Media LLC
Published
2025-10-01
Volume
24
Issue
1
Pages
381-381
ISSN
1475-2840 (ISSN-L)
DOI
10.1186/s12933-025-02938-8
PMC
PMC12487381
OpenAlex
W4414700639
Cited by
19
References
208
Citations by year
2026: 18 · 2025: 1
FWCI
2.16
Type
journal article
Language
en
Open access
Licence
Locations
  • Cardiovascular Diabetology (publishedVersion, cc-by-nc-nd)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • the Technique Plans Foundation of Lanzhou City (2022-ZD-97)
  • National Natural Science Foundation of China (82260050, 82460177)
  • Lanzhou University 2023 College Students Innovation and Entrepreneurship (20230060190)
  • The Hospital Fund of the First Hospital of Lanzhou University (ldyyyn2020-93)
  • Gansu Province Science and Technology Plan Project - Joint Research Fund (25JRRA1251)
Topics
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
endocrine disruptors, cardiometabolic health, obesity, type 2 diabetes, cardiovascular disease, metabolic syndrome, impaired glucose metabolism, prenatal exposure, early life exposure, environmental risk factors, endocrine disruption, chemical regulation
MeSH terms
Cardiometabolic Risk Factors, Animals, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Environmental Exposure, Female, Humans, Obesity, Pregnancy, Prenatal Exposure Delayed Effects, Risk Assessment, Metabolic Syndrome, Endocrine Disruptors

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