Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment
Open accessAbstract
The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.
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Nanoparticles allow adequate targeted transport of phytochemicals to the central nervous system with controlled release time.
“After several decades of research in nanotechnology to transport drugs to the CNS, it is possible to have nanoparticles that allow an adequate transport of phytochemicals in a targeted way and with a control in the release time [213,214].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [213]
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References 174 · Cited by 290
Research works printed but not linked: 3
- [26]Council of Europe The European Pharmacopeia. 6th ed. Vol. 2. Strasburg, France, 2007.
- [57]Mukhopadhyay S Vander Heiden MG McCormick F The metabolic landscape of RAS-driven cancers from biology to therapy Nature Cancer 2021 2 271 283 10.1038/s43018-021-00184-x 33870211 PMC8045781 · DOI · Paper page
- [125]https://pubmed.ncbi.nlm.nih.gov/28267520/. No Title.
- Authors
- Sharifi-Rad, J., Quispe, C., Butnariu, M., Rotariu, L. S., Sytar, O., Sestito, S., Rapposelli, S., Akram, M., Iqbal, M., Krishna, A., Kumar, N. V. A., Braga, S. S., Cardoso, S. M., Jafernik, K., Ekiert, H., Cruz-Martins, N., Szopa, A., Villagran, M., Mardones, L., Martorell, M., Docea, A. O., & Calina, D.
- Affiliations
- Arturo Prat University (CL)
- Univesity of Life Science "King Mihai I" from Timisoara (RO)
- Taras Shevchenko National University of Kyiv (UA)
- University of Pisa (IT)
- Government College University, Faisalabad (PK)
- Dow University of Health Sciences (PK)
- Manipal Academy of Higher Education (IN)
- University of Aveiro (PT)
- Jagiellonian University (PL)
- Universidad Católica de la Santísima Concepción (CL)
- University of Concepción (CL)
- University of Medicine and Pharmacy of Craiova (RO)
- Corresponding author
- Butnariu, Monica
- Szopa, Agnieszka
- ORCID
- Sharifi-Rad, Javad
- Quispe, Cristina
- Butnariu, Monica
- Rotariu, Lia Sanda
- Sytar, Oksana
- Sestito, Simona
- Rapposelli, Simona
- Akram, Muhammad
- Iqbal, Mehwish
- Krishna, Akash
- Kumar, Nanjangud Venkatesh Anil
- Braga, Susana S.
- Cardoso, Susana M.
- Jafernik, Karolina
- Ekiert, Halina
- Szopa, Agnieszka
- Mardones, Lorena
- Martorell, Miquel
- Docea, Anca Oana
- Venue
- Cancer Cell International
- Published
- 2021-06-24
- Volume
- 21
- Issue
- 1
- Pages
- 318-318
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC8223345
- OpenAlex
- W3173169652
- Cited by
- 290
- References
- 174
- Citations by year
- 2026: 29 · 2025: 48 · 2024: 72 · 2023: 67 · 2022: 63 · 2021: 11
- FWCI
- 3.67
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Homo Politicus (Academy of Humanities and Economics in Lodz) (submittedVersion, cc-by)
- Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (submittedVersion, cc-by)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UnissResearch (Università degli Studi di Sassari) (submittedVersion)
- Greater South Information System
- Funders
- Universidade de Aveiro (UIDB/50006/2020)
- Ministério da Ciência, Tecnologia e Ensino Superior (UIDB 50006/2020)
- Rede de Química e Tecnologia (UIDB/50006/2020)
- Laboratório Associado para a Química Verde (UIDB/50006/2020)
- Fundação para a Ciência e a Tecnologia (UIDB/50006/2020)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Pharmacology and Nanomedicine Research
- Keywords
- chitosan nanoparticles, nanomedicine, anticancer drug delivery, controlled drug release, bioavailability, nanoparticle stability, drug toxicity reduction, cancer therapy, nanomaterial safety
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