Recent advances in targeted drug delivery systems for resistant colorectal cancer
Open accessAbstract
Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (MDR) is one of the major obstacles in CRC treatment. Tumor microenvironment plus genomic instability, tumor derived exosomes (TDE), cancer stem cells (CSCs), circulating tumor cells (CTCs), cell-free DNA (cfDNA), as well as cellular signaling pathways are important issues regarding resistance. Since non-targeted therapy causes toxicity, diverse side effects, and undesired efficacy, targeted therapy with contribution of various carriers has been developed to address the mentioned shortcomings. In this paper the underlying causes of MDR and then various targeting strategies including exosomes, liposomes, hydrogels, cell-based carriers and theranostics which are utilized to overcome therapeutic resistance will be described. We also discuss implication of emerging approaches involving single cell approaches and computer-aided drug delivery with high potential for meeting CRC medical needs.
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Specific targeting strategies are being developed to deliver drugs to the colorectal TME, which is characterized by high levels of ROS, acidic pH, and elevated temperature.
“Specific targeting strategies are being developed to deliver drugs to the colorectal TME, which is characterized by high levels of ROS, acidic pH, and elevated temperature [221].”
From Mechanisms and Strategies to Overcome Drug Resistance in Colorectal Cancer (2025) · cites this paper as [221]
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References 164 · Cited by 65
Research works printed but not linked: 1
- [127]Wang ZH Liu JM Zhao N Li CY Lv SW Hu Y Lv H Wang D Wang S Cancer cell macrophage membrane camouflaged persistent luminescent nanoparticles for imaging-guided photothermal therapy of colorectal cancer ACS Appl Nano Mater 2020 3 7105 7118 10.1021/ACSANM.0C01433/SUPPL_FILE/AN0C01433_SI_001.PDF · DOI
- Authors
- Sharifi-Azad, M., Fathi, M., Cho, W. C., Barzegari, A., Dadashi, H., Dadashpour, M., & Jahanban-Esfahlan, R.
- Affiliations
- Tabriz University of Medical Sciences (IR)
- Queen Elizabeth Hospital (CN)
- Semnan University of Medical Sciences (IR)
- Corresponding author
- Dadashpour, Mehdi
- Venue
- Cancer Cell International
- Published
- 2022-05-19
- Volume
- 22
- Issue
- 1
- Pages
- 196-196
- ISSN
- 1475-2867 (ISSN-L)
- PMC
- PMC9117978
- OpenAlex
- W4280564779
- Cited by
- 65
- References
- 164
- Citations by year
- 2026: 12 · 2025: 27 · 2024: 15 · 2023: 6 · 2022: 5
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cancer Cell International (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Tabriz University of Medical Sciences
- University of Tabriz
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- colorectal cancer, multidrug resistance, targeted drug delivery, tumor microenvironment, tumor-derived exosomes, cancer stem cells, circulating tumor cells, cell-free DNA, liposomes, hydrogels, theranostics
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