Relationship between coffee consumption and stroke risk in Korean population: The Health Examinees (HEXA) Study
Open accessAbstract
BACKGROUND: Although coffee consumption is increasing rapidly, the results of previous studies regarding the association between coffee consumption and stroke risk have been conflicting. This was a multi-center cross-sectional study that aimed to evaluate the relationship between coffee consumption and stroke risk in Korean population. METHODS: Data were obtained from the Health Examinees (HEXA) Study, which involved 146,830 individuals aged 40-69 years. Coffee consumption was categorized as none, < 1 cup/day, 1 to < 3 cups/day, and ≥ 3 cups/day. We used logistic regression models to examine the association between coffee consumption and the risk of stroke while controlling for potential confounders and performed subgroup analyses. RESULTS: After adjusting for age and various possible confounders, high coffee consumption was associated with a 38% lower odds ratio for stroke in women (none vs. ≥ 3 cups/day: OR, 0.62; 95% CI 0.47-0.81; P for trend < 0.0001). No significant association was found in men (none vs. ≥ 3 cups/day: OR, 0.84; 95% CI, 0.66-1.07; P for trend = 0.1515). In analyses stratified by covariates, an inverse association between coffee consumption and stroke risk was most evident among healthy women who were younger, non-obese, non-hypertensive, non-diabetic, non-smokers, and non-alcohol drinkers. CONCLUSION: Our results suggest that higher coffee consumption may have protective benefits with regards to stroke risk in middle-aged Korean women.
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Higher coffee consumption (≥3 cups/day) reduced the incidence of stroke in the 2015 NHANES study.
“Multivariate analysis found that higher coffee consumption (≥3 cups/day) reduced the incidence of stroke [92].”
From Effect of Caffeine Consumption on the Risk for Neurological and Psychiatric Disorders: Sex Differences in Human (2020) · cites this paper as [92]
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References 45 · Cited by 27
Research works printed but not linked: 1
- [16]World Health Organization: Obesity: preventing and managing the global epidemic. WHO technical report series no 894, Geneva, Switzerland. WHO 2000. 11234459
- Authors
- Lee, J., Lee, J.-E., & Kim, Y.
- Affiliations
- Ewha Womans University (KR)
- Corresponding author
- Kim, Yuri
- Venue
- Nutrition Journal
- Published
- 2017-01-31
- Volume
- 16
- Issue
- 1
- Pages
- 7-7
- ISSN
- 1475-2891 (ISSN-L)
- PMC
- PMC5282694
- OpenAlex
- W2581784214
- Cited by
- 27
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 1 · 2017: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Nutrition Journal (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention
- Topics
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- coffee consumption, stroke risk, stroke prevention, sex differences, middle-aged adults, Korean population, protective factors
- MeSH terms
- Aged, Coffee, Cross-Sectional Studies, Female, Humans, Life Style, Male, Middle Aged, Surveys and Questionnaires, Risk Factors, Socioeconomic Factors, Prevalence, Logistic Models, Stroke, Asian People, Republic of Korea
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