The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.
Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies
Open accessAbstract
Cancer is a leading cause of death worldwide, particularly because of its high mortality rate in patients who are diagnosed at late stages. Conventional biomarkers originating from blood are widely used for cancer diagnosis, but their low sensitivity and specificity limit their widespread application in cancer screening among the general population. Currently, emerging studies are exploiting novel, highly-accurate biomarkers in human body fluids that are obtainable through minimally invasive techniques, which is defined as liquid biopsy. Circular RNAs (circRNAs) are a newly discovered class of noncoding RNAs generated mainly by pre-mRNA splicing. Following the rapid development of high-throughput transcriptome analysis techniques, numerous circRNAs have been recognized to exist stably and at high levels in body fluids, including plasma, serum, exosomes, and urine. CircRNA expression patterns exhibit distinctly differences between patients with cancer and healthy controls, suggesting that circRNAs in body fluids potentially represent novel biomarkers for monitoring cancer development and progression. In this study, we summarized the expression of circRNAs in body fluids in a pan-cancer dataset and characterized their clinical applications in liquid biopsy for cancer diagnosis and prognosis. In addition, a user-friendly web interface was developed to visualize each circRNA in fluids (https://mulongdu.shinyapps.io/circrnas_in_fluids/).
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5 retracted
Zhang, H., Deng, T., Ge, S., Liu, Y., Bai, M., Zhu, K., Fan, Q., Li, J., Ning, T., Tian, F., et al. (2019) · Oncogene · doi:10.1038/s41388-018-0619-z · Cited by 303
RetractedRong, D., Lu, C., Zhang, B., Fu, K., Zhao, S., Tang, W., & Cao, H. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0958-6 · Cited by 240
RetractedZhao, Z., Ji, M., Wang, Q., He, N., & Li, Y. (2019) · Molecular Therapy Nucleic Acids · doi:10.1016/j.omtn.2019.07.012 · Cited by 199
RetractedWu, G., Zhou, W., Pan, X., Sun, Z., Sun, Y., Xu, H., Shi, P., Li, J., Gao, L., & Tian, X. (2020) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.12.025 · Cited by 84
Self-citationRetractedWeng, Q., Chen, M., Li, M., Zheng, Y., Shao, G., Fan, W., Xu, X., & Ji, J. (2018) · Journal of Medical Genetics · doi:10.1136/jmedgenet-2018-105440 · Cited by 71
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Siegel, R. L., Miller, K. D., & Jemal, A. (2020) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21590 · Cited by 20,444
Circular RNAs are a large class of animal RNAs with regulatory potency
Memczak, S., Jens, M., Elefsinioti, A., Torti, F., Krueger, J., Rybak, A., Maier, L., Mackowiak, S. D., Gregersen, L. H., Munschauer, M., et al. (2013) · Nature · doi:10.1038/nature11928 · Cited by 7,990
Natural RNA circles function as efficient microRNA sponges
Hansen, T. B., Jensen, T. I., Clausen, B. H., Bramsen, J. B., Finsen, B., Damgaard, C. K., & Kjems, J. (2013) · Nature · doi:10.1038/nature11993 · Cited by 7,985
Forouzanfar, M. H., Afshin, A., Alexander, L. T., Anderson, H. R., Bhutta, Z. A., Biryukov, S., Brauer, M., Burnett, R., Cercy, K., Charlson, F. J., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31679-8 · Cited by 7,698
Cited by
RNA polymerase II speed: a key player in controlling and adapting transcriptome composition
Muniz, L., Nicolas, E., & Trouche, D. (2021) · The EMBO Journal · doi:10.15252/embj.2020105740 · Cited by 198
“Moreover, because circRNAs are very stable and can be detected in body fluids (blood and urine, for example), they are now considered as promising disease biomarkers (Vo et al , 2019; Wang et al , 2021).”
Metadata
- Authors
- Wang, S., Zhang, K., Tan, S., Xin, J., Yuan, Q., Xu, H., Xu, X., Liang, Q., Christiani, D. C., Wang, M., Liu, L., & Du, M.
- Venue
- Molecular Cancer
- Published
- 2021-01-11
- Volume
- 20
- Issue
- 1
- Pages
- 13-13
- ISSN
- 1476-4598 (ISSN-L)
- OpenAlex
- W3119921402
- Cited by
- 331
- References
- 95
- FWCI
- 18.38
- Type
- journal article
- Language
- en
- Open access
- gold
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- Wang, S., Zhang, K., Tan, S., Xin, J., Yuan, Q., Xu, H., Xu, X., Liang, Q., Christiani, D. C., Wang, M., Liu, L., & Du, M. (2021). Circular RNAs in body fluids as cancer biomarkers: the new frontier of liquid biopsies. Molecular Cancer. https://doi.org/10.1186/s12943-020-01298-z
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