Recent advances in exosome-mediated nucleic acid delivery for cancer therapy
Open accessAbstract
Cancer is a leading public health problem worldwide. Its treatment remains a daunting challenge, although significant progress has been made in existing treatments in recent years. A large concern is the poor therapeutic effect due to lack of specificity and low bioavailability. Gene therapy has recently emerged as a powerful tool for cancer therapy. However, delivery methods limit its therapeutic effects. Exosomes, a subset of extracellular vesicles secreted by most cells, have the characteristics of good biocompatibility, low toxicity and immunogenicity, and great designability. In the past decades, as therapeutic carriers and diagnostic markers, they have caught extensive attention. This review introduced the characteristics of exosomes, and focused on their applications as delivery carriers in DNA, messenger RNA (mRNA), microRNA (miRNA), small interfering RNA (siRNA), circular RNA (circRNA) and other nucleic acids. Meanwhile, their application in cancer therapy and exosome-based clinical trials were presented and discussed. Through systematic summarization and analysis, the recent advances and current challenges of exosome-mediated nucleic acid delivery for cancer therapy are introduced, which will provide a theoretical basis for the development of nucleic acid drugs. Graphical Abstract
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Intradermal delivery of mRNA-loaded exosomes using microneedles has shown promise in efficiently secreting specific proteins.
“In recent years, intradermal delivery of mRNA-loaded exosomes using microneedles has shown promise in efficiently secreting specific proteins [130–132].”
From Exosome for mRNA delivery: Strategies and therapeutic applications (2024) · cites this paper as [132]
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References 209 · Cited by 306
- Authors
- Zhang, Y., Liu, Q., Zhang, X., Huang, H., Tang, S., Chai, Y., Xu, Z., Li, M., Chen, X., Liu, J., & Yang, C.
- Affiliations
- Shenzhen University (CN)
- Chinese University of Hong Kong, Shenzhen (CN)
- Corresponding author
- Liu, Jia
- Yang, Chengbin
- ORCID
- Venue
- Journal of Nanobiotechnology
- Published
- 2022-06-14
- Volume
- 20
- Issue
- 1
- Pages
- 279-279
- ISSN
- 1477-3155 (ISSN-L)
- PMC
- PMC9194774
- OpenAlex
- W4282834851
- Cited by
- 306
- References
- 209
- Citations by year
- 2026: 49 · 2025: 99 · 2024: 76 · 2023: 61 · 2022: 20
- FWCI
- 6.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Nanobiotechnology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- the National Natural Science Foundation of China (81900264)
- Natural Science Foundation of Guangdong Province (2021A1515012159, 2019A1515012163)
- the Shenzhen Science and Technology Innovation Fund (JCYJ20210324130609027)
- the Project of Administration of Traditional Chinese Medicine Guangdong Province (20211347)
- the Longgang Medical and Health Science and Technology Project (LGKCYLWS2020040)
- Guangdong MedicalScience and Technology Research Funding (A2019359)
- University Stable Support Research Funding of Shenzhen (20200813153346001)
- SZU Top Ranking Project (86000000210)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, extracellular vesicles, nucleic acid delivery, cancer therapy, gene therapy, mRNA delivery, microRNA delivery, siRNA delivery, circular RNA
- MeSH terms
- Humans, Neoplasms, Nucleic Acids, Drug Delivery Systems, RNA, Small Interfering, Exosomes
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