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Cited by 47Advanced Nanomaterials in CatalysisWound Healing and TreatmentsNanoplatforms for cancer theranostics

Functional molecule-mediated assembled copper nanozymes for diabetic wound healing

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Huang, Wenyan, Xu, Ping, Fu, Xiaoxue, Yang, Jiaxin, Jing, Weihong, Cai, Yucen, Zhou, Yingjuan, Tao, Rui +1 more·2023·Journal of Nanobiotechnology
DOI 10.1186/s12951-023-02048-1PMC PMC10464099
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Abstract

BACKGROUND: The complex hyperglycemic, hypoxic, and reactive oxygen species microenvironment of diabetic wound leads to vascular defects and bacterial growth and current treatment options are relatively limited by their poor efficacy. RESULTS: Herein, a functional molecule-mediated copper ions co-assembled strategy was constructed for collaborative treatment of diabetic wounds. Firstly, a functional small molecule 2,5-dimercaptoterephthalic acid (DCA) which has symmetrical carboxyl and sulfhydryl structure, was selected for the first time to assisted co-assembly of copper ions to produce multifunctional nanozymes (Cu-DCA NZs). Secondly, the Cu-DCA NZs have excellent multicatalytic activity, and photothermal response under 808 nm irradiation. In vitro and in vivo experiments showed that it not only could efficiently inhibit bacterial growth though photothermal therapy, but also could catalyze the conversion of intracellular hydrogen peroxide to oxygen which relieves wound hypoxia and improving inflammatory accumulation. More importantly, the slow release of copper ions could accelerate cellular proliferation, migration and angiogenesis, synergistically promote the healing of diabetic wound furtherly. CONCLUSIONS: The above results indicate that this multifunctional nanozymes Cu-DCA NZs may be a potential nanotherapeutic strategy for diabetic wound healing.

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  • Copper-treated wounds show significant increase in VEGF and number of blood vessels compared to controls.

    “One of the notorious effects noticed in some of these studies was the significant increase in VEGF and the number of blood vessels in the copper-treated wounds as compared to the controls [72,73,75,77,78,84,97,103].”

    From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [78]

    The Results section’s histological and immunohistochemical analysis reports more neovascularisation and significantly higher CD31 expression in Cu-DCA NZs + NIR wounds than in controls. But it reports significantly lower wound VEGF expression in that group on day 14. Higher VEGF was observed in treated cells in vitro, not in the wounds. (LLM, conf=0.90)

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  • Copper-containing biomaterials consistently demonstrate enhanced healing of non-infected wounds in animal models compared to controls.

    “These studies consistently demonstrate enhanced healing of non-infected wounds [71,72,73,74,75,76], including those in diabetic [77,78,79,80,81,82,83] and burn-related [84,85,86,87,88,89,90] animal models when compared to control materials.”

    From The Journey of Copper-Impregnated Dressings in Wound Healing: From a Medical Hypothesis to Clinical Practice (2025) · cites this paper as [78]

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Cited by

Sorted by citations

Authors
Huang, W., Xu, P., Fu, X., Yang, J., Jing, W., Cai, Y., Zhou, Y., Tao, R., & Yang, Z.
Affiliations
Chongqing Medical University (CN)
Corresponding author
Tao, Rui
ORCID
Venue
Journal of Nanobiotechnology
Publisher
Springer Science and Business Media LLC
Published
2023-08-25
Volume
21
Issue
1
Pages
294-294
ISSN
1477-3155 (ISSN-L)
DOI
10.1186/s12951-023-02048-1
PMC
PMC10464099
OpenAlex
W4386156461
Cited by
47
References
0
Citations by year
2026: 14 · 2025: 17 · 2024: 14 · 2023: 2
FWCI
3.46
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Nanobiotechnology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Youth Talent Foundation in College of Pharmacy, Chongqing Medical University (No. YXY2019QNGD1)
Topics
  • Physical Sciences › Materials Science › Materials Chemistry › Advanced Nanomaterials in Catalysis
  • Health Sciences › Medicine › Rehabilitation › Wound Healing and Treatments
  • Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Keywords
diabetic wound healing, photothermal therapy, hydrogen peroxide catalysis, reactive oxygen species, wound hypoxia, antibacterial activity, angiogenesis, nanomedicine
MeSH terms
Hypoxia, Catalysis, Copper, Diabetes Mellitus, Humans, Hydrogen Peroxide, Wound Healing, Cell Proliferation

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