Resilience acts as a moderator in the relationship between infertility-related stress and fertility quality of life among women with infertility: a cross-sectional study
Open accessAbstract
BACKGROUND: Infertility-related stress can seriously impact the fertility quality of life (QoL) of infertile women. Resilience, as a coping resource, can effectively combat psychological stress. This study aimed to evaluate the fertility QoL of infertile women and to examine whether resilience moderates the association of infertility-related stress with fertility QoL. METHODS: This cross-sectional study was conducted in northeast of China from December 2017 to February 2018. Out of 559 women outpatients with infertility, 498 (89.1%) completed self-reported questionnaires including the FertiQoL Scale, Fertility Problem Inventory (FPI) and Connor-Davidson Resilience Scale (CD-RISC). Hierarchical multiple regression analysis and simple slope analysis were applied to explore the influencing factors related to fertility QoL as well as to examine the moderating effect of resilience on the association of infertility-related stress with fertility QoL. RESULTS: The mean FertiQoL score was 64.54 ± 16.90 among the participants. Household monthly income and causes of infertility were significantly related to fertility QoL. In addition, infertility-related stress was negatively related to fertility QoL, and resilience was positively associated with fertility QoL, explaining 36.3% of the variance. Resilience moderated the association of infertility-related stress with fertility QoL. Specifically, the effect of infertility-related stress on fertility QoL varied by low(1 SD below the mean, B = - 0.496, β = - 0.714, P < 0.001), mean (B = - 0.293, β = - 0.422, P < 0.001) and high (1 SD above the mean, B = - 0.090, β = - 0.130, P < 0.001) levels of resilience. The higher resilience was, the weaker the effect of infertility-related stress on fertility QoL was. CONCLUSIONS: Overall, women with infertility in China had relatively low FertiQoL scores. Resilience influenced the association of infertility-related stress with fertility QoL. Infertile patients' psychological status must be addressed and adequate resilience-based interventions such as mindfulness-based skills should be provided to improve fertility QoL of women with infertility.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 59 · Cited by 142
Research works printed but not linked: 47
- [1]Zegers-Hochschild F Adamson GD Dyer S Racowsky C de Mouzon J Sokol R The international glossary on infertility and fertility care, 2017 Fertil Steril 2017 108 3 393 406 28760517
- [2]Thoma ME Mclain AC Louis JF King RB Trumble AC Sundaram R Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach Fertil Steril 2013 99 5 1324 1331 23290741 PMC3615032
- [3]Slama R Hansen OK Ducot B Bohet A Sorensen D Giorgis Allemand L Estimation of the frequency of involuntary infertility on a nation-wide basis Hum Reprod 2012 27 5 1489 1498 22416008
- [4]Zhou Z Zheng D Wu H Li R Xu S Kang Y Epidemiology of infertility in China: a population-based study BJOG 2018 125 4 432 441 29030908
- [5]Lakatos E Szigeti JF Ujma PP Sexty R Balog P Anxiety and depression among infertile women: a cross-sectional survey from Hungary BMC Womens Health 2017 17 1 48 28738833 PMC5525318
- [6]Jansen NA Saint Onge JM An internet forum analysis of stigma power perceptions among women seeking fertility treatment in the United States Soc Sci Med 2015 147 184 189 26584236
- [7]Namavar Jahromi B Mansouri M Forouhari S Poordast T Salehi A Quality of life and its influencing factors of couples referred to an infertility center in shiraz Iran Int J Ferti Steri 2018 11 4 293 297 PMC5641461 29043705
- [8]WHO The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization Soc Sci Med 1995 41 10 1403 1409 8560308
- [9]Namdar A Naghizadeh MM Zamani M Yaghmaei F Sameni MH Quality of life and general health of infertile women Health Qual Life Outcomes 2017 15 1 139 28701163 PMC5508693
- [10]Aduloju OP Olaogun OD Aduloju T Quality of life in women of reproductive age: a comparative study of infertile and fertile women in a Nigerian tertiary Centre J Obstet Gynaecol 2018 38 2 247 251 28920515
- [11]Masoumi SZ Garousian M Khani S Oliaei SR Shayan A Comparison of quality of life, sexual satisfaction and marital satisfaction between fertile and infertile couples Int J Fertil Steril. 2016 10 3 290 296 27695611 PMC5023039
- [12]Gameiro S Boivin J Peronace L Verhaak CM Why do patients discontinue fertility treatment? A systematic review of reasons and predictors of discontinuation in fertility treatment Hum Reprod Update 2012 18 6 652 669 22869759 PMC3461967
- [14]Fu B Qin N Cheng L Tang G Cao Y Yan C Development and validation of an infertility stigma scale for Chinese women J Psychosom Res 2015 79 1 69 75 25499618
- [16]Greil AL Slauson-Blevins K McQuillan J The experience of infertility: a review of recent literature Sociol Health Illn 2010 32 1 140 162 20003036 PMC3383794
- [17]Cserepes RE Kollár J Sápy T Wischmann T Bugán A Effects of gender roles, child wish motives, subjective well-being, and marital adjustment on infertility-related stress: a preliminary study with a Hungarian sample of involuntary childless men and women Arch Gynecol Obstet 2013 288 4 925 932 23553201
- [18]Kim JH Shin HS Yun EK A dyadic approach to infertility stress, marital adjustment, and depression on quality of life in infertile couples J Holist Nurs 2018 36 1 6 14 29436974
- [19]Youssef-Morgan CM Luthans F Psychological capital and well-being Stress Health 2015 31 3 180 188 26250352
- [21]Popa-Velea O Diaconescu L Jidveian PM Truţescu C Resilience and active coping style: effects on the self-reported quality of life in cancer patients Int J Psychiatry Med 2017 52 2 124 136 28792288
- [22]Liu L Xu X Xu N Wang L Disease activity, resilience and health-related quality of life in Chinese patients with rheumatoid arthritis: a multi-center, cross-sectional study Health Qual Life Outcomes 2017 15 1 149 28738816 PMC5525274
- [23]Li MY Yang YL Liu L Wang L Effects of social support, hope and resilience on quality of life among Chinese bladder cancer patients: a cross-sectional study Health Qual Life Outcomes 2016 14 73 27153944 PMC4859956
- [24]Herrmann D Scherg H Verres R von Hagens C Strowitzki T Wischmann T Resilience in infertile couples acts as a protective factor against infertility-specific distress and impaired quality of life J Assist Reprod Genet 2011 28 11 1111 1117 21901362 PMC3224175
- [25]Wu WW Tsai SY Liang SY Liu CY Jou ST Berry DL The mediating role of resilience on quality of life and cancer symptom distress in adolescent patients with cancer J Pediatr Oncol Nurs 2015 32 5 304 313 25612835
- [26]Palm-fischbacher S Ehlert U Dispositional resilience as a moderator of the relationship between chronic stress and irregular menstrual cycle J Psychosom Obstet Gynaecol 2014 35 2 42 50 24824598
- [27]Rainone N Chiodi A Lanzillo R Magri V Napolitano A Morra VB Affective disorders and health-related quality of life (HRQoL) in adolescents and young adults with multiple sclerosis (MS): the moderating role of resilience Qual Life Res 2017 26 3 727 736 27928696
- [28]Li M Wang L The associations of psychological stress with depressive and anxiety symptoms among Chinese bladder and renal cancer patients: the mediating role of resilience PLoS One 2016 11 4 e0154729 27128438 PMC4851357
- [29]Hsu PY Lin MW Hwang JL Lee MS Wu MH The fertility quality of life (FertiQoL) questionnaire in Taiwanese infertile couples Taiwan J Obstet Gynecol 2013 52 2 204 209 23915852
- [30]Boivin J Takefman J Braverman A The fertility quality of life (FertiQoL) tool: development and general psychometric properties Fertil Steril 2011 96 2 409 415 21458806 PMC7094343
- [32]Newton CR Sherrard W Glavac I The fertility problem inventory: measuring perceived infertility-related stress Fertil Steril 1999 72 1 54 62 10428148
- [33]Peng T Coates R Merriman G Zhao Y Maycock B Testing the psychometric properties of mandarin version of the fertility problem inventory (M-FPI) in an infertile Chinese sample J Psychosom Obstet Gynaecol 2011 32 4 173 181 21995736
- [36]Wu L Tan Y Liu Y Factor structure and psychometric evaluation of the Connor-Davidson resilience scale in a new employee population of China BMC Psychiatry 2017 17 1 49 28152997 PMC5290619
- [37]Karabulut A Özkan S Oğuz N Predictors of fertility quality of life (FertiQoL) in infertile women: analysis of confounding factors Eur J Obstet Gynecol Reprod Biol 2013 170 1 193 197 23870187
- [38]Aarts JW Huppelschoten AG van Empel IW Boivin J Verhaak CM Kremer JA How patient-centred care relates to patients' quality of life and distress: a study in 427 women experiencing infertility Hum Reprod 2012 27 2 488 495 22108249
- [39]Santoro N Eisenberg E Trussell JC Craig LB Gracia C Huang H Fertility-related quality of life from two RCT cohorts with infertility: unexplained infertility and polycystic ovary syndrome Hum Reprod 2016 31 10 2268 2279 27402910 PMC5027926
- [40]Neumann K Kayser J Depenbusch M Schultze-Mosgau A Griesinger G Can a quality-of-life assessment assist in identifying women at risk of prematurely discontinuing IVF treatment? A prospective cohort study utilizing the FertiQoL questionnaire Arch Gynecol Obstet 2018 298 1 223 229 29869088
- [41]Casu G Ulivi G Zaia V Fernandes Martins MDC Parente Barbosa C Gremigni P Spirituality, infertility-related stress, and quality of life in Brazilian infertile couples: analysis using the actor-partner interdependence mediation model Res Nurs Health 2018 41 2 156 165 29399819
- [42]Hasanpour S Bani S Mirghafourvand M Yahyavi KF Mental health and its personal and social predictors in infertile women J Caring Sci 2014 3 1 37 45 25276747 PMC4134165
- [43]Cheng CY Stevenson EL Yang CT Liou SR Stress and quality of life for Taiwanese women who underwent infertility treatment J Obstet Gynecol Neonatal Nurs 2018 47 4 498 508 29715441
- [44]Lau JT Wang Q Cheng Y Kim JH Yang X Tsui HY Infertility-related perceptions and responses and their associations with quality of life among rural Chinese infertile couples J Sex Marital Ther 2008 34 3 248 267 18398763
- [45]Sameroff AJ Mackenzie MJ Research strategies for capturing transactional models of development: the limits of the possible Dev Psychopathol 2003 15 3 613 640 14582934
- [47]Masoumi SZ Khani S Kazemi F Kalhori F Ebrahimi R Roshanaei G Effect of marital relationship enrichment program on marital satisfaction, marital intimacy, and sexual satisfaction of infertile couples Int J Fertil Steril 2017 11 3 197 204 28868842 PMC5582148
- [48]Pedro J Sobral MP Mesquita-Guimarães J Leal C Costa ME Martins MV Couples' discontinuation of fertility treatments: a longitudinal study on demographic, biomedical, and psychosocial risk factors J Assist Reprod Genet 2017 34 2 217 224 27900611 PMC5306409
- [49]Moura-Ramos M Gameiro S Canavarro MC Soares I Assessing infertility stress: re-examining the factor structure of the fertility problem inventory Hum Reprod 2012 27 2 496 505 22101025
- [52]Peterson B Boivin J Norré J Smith C Thorn P Wischmann T An introduction to infertility counseling: a guide for mental health and medical professionals J Assist Reprod Genet 2012 29 3 243 248 22290604 PMC3288135
- [53]Johnston MC Porteous T Crilly MA Burton CD Elliott A Iversen L Physical disease and resilient outcomes: a systematic review of resilience definitions and study methods Psychosomatics 2015 56 2 168 180 25620566 PMC7111641
- [54]Stonnington CM Darby B Santucci A A resilience intervention involving mindfulness training for transplant patients and their caregivers Clin Transpl 2016 30 11 1466 1472 27618687
- [56]Zalta AK Tirone V Siedjak J A pilot study of tailored cognitive-behavioral resilience training for trauma survivors with subthreshold distress J Trauma Stress 2016 29 3 268 272 27121865 PMC4899200
- [57]Schmidt M Haglund K Debrief in emergency departments to improve compassion fatigue and promote resiliency J Trauma Nurs 2017 24 5 317 322 28885522
- Authors
- Li, Y., Zhang, X., Shi, M., Guo, S., & Wang, L.
- Affiliations
- China Medical University (CN)
- Shenyang Women and Infants Hospital (CN)
- Corresponding author
- Guo, Shuaishuai
- Wang, Lie
- Venue
- Health and Quality of Life Outcomes
- Published
- 2019-02-15
- Volume
- 17
- Issue
- 1
- Pages
- 38-38
- ISSN
- 1477-7525 (ISSN-L)
- PMC
- PMC6377764
- OpenAlex
- W2922176289
- Cited by
- 142
- References
- 59
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 8 · 2023: 16 · 2022: 17 · 2021: 22 · 2020: 62 · 2019: 1
- FWCI
- 24.39
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Health and Quality of Life Outcomes (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Social Sciences › Psychology › Clinical Psychology › Resilience and Mental Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Maternal Mental Health During Pregnancy and Postpartum
- Keywords
- infertility, infertility-related stress, FertiQoL, resilience, moderating effect, women's psychological well-being, causes of infertility, household income, mindfulness-based interventions, Connor-Davidson Resilience Scale, Fertility Problem Inventory, China, Northeast China, resilience interventions, coping with infertility, mindfulness-based stress reduction
- MeSH terms
- Adult, China, Cross-Sectional Studies, Female, Humans, Infertility, Female, Infertility, Male, Male, Quality of Life, Regression Analysis, Stress, Psychological, Resilience, Psychological, Self Report
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review