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Cited by 295

The DOI matches its Crossref record; 291 of the 291 references it cites were found in a registry or an index.

Insulin-like growth factor-1 deficiency and metabolic syndrome

Open access
Aguirre, G. A., De Ita, J. Rodríguez, de la Garza, R. G., Castilla-Cortazar, I.·2016·Journal of Translational Medicine
DOI 10.1186/s12967-015-0762-z
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Abstract

Consistent evidence associates IGF-1 deficiency and metabolic syndrome. In this review, we will focus on the metabolic effects of IGF-1, the concept of metabolic syndrome and its clinical manifestations (impaired lipid profile, insulin resistance, increased glucose levels, obesity, and cardiovascular disease), discussing whether IGF-1 replacement therapy could be a beneficial strategy for these patients. The search plan was made in Medline for Pubmed with the following mesh terms: IGF-1 and "metabolism, carbohydrate, lipids, proteins, amino acids, metabolic syndrome, cardiovascular disease, diabetes" between the years 1963-2015. The search includes animal and human protocols. In this review we discuss the relevant actions of IGF-1 on metabolism and the implication of IGF-1 deficiency in the establishment of metabolic syndrome. Multiple studies (in vitro and in vivo) demonstrate the association between IGF-1 deficit and deregulated lipid metabolism, cardiovascular disease, diabetes, and an altered metabolic profile of diabetic patients. Based on the available data we propose IGF-1 as a key hormone in the pathophysiology of metabolic syndrome; due to its implications in the metabolism of carbohydrates and lipids. Previous data demonstrates how IGF-1 can be an effective option in the treatment of this worldwide increasing condition. It has to distinguished that the replacement therapy should be only undertaken to restore the physiological levels, never to exceed physiological ranges.

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Metadata

Authors
Aguirre, G. A., De Ita, J. R., de la Garza, R. G., & Castilla-Cortazar, I.
Venue
Journal of Translational Medicine
Publisher
Springer Science and Business Media LLC
Published
2016-01-06
Volume
14
Issue
1
Pages
3-3
ISSN
1479-5876 (ISSN-L)
DOI
10.1186/s12967-015-0762-z
OpenAlex
W2232504117
Cited by
295
References
291
FWCI
25.69
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Insulin-like growth factor-1 deficiency and metabolic syndrome. https://app.cochat.ai/papers/10.1186/s12967-015-0762-z
The paper
Aguirre, G. A., De Ita, J. R., de la Garza, R. G., & Castilla-Cortazar, I. (2016). Insulin-like growth factor-1 deficiency and metabolic syndrome. Journal of Translational Medicine. https://doi.org/10.1186/s12967-015-0762-z

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.