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Cited by 76Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsInflammation biomarkers and pathways

TREM2 regulates innate immunity in Alzheimer’s disease

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Li, Jiang-Tao, Zhang, Ying·2018·Journal of Neuroinflammation
DOI 10.1186/s12974-018-1148-yPMC PMC5899410
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Abstract

Recent research has shown that the triggering receptor expressed on myeloid cells 2 (TREM2) in microglia is closely related to the pathogenesis of Alzheimer's disease (AD). The mechanism of this relationship, however, remains unclear. TREM2 is part of the TREM family of receptors, which are expressed primarily in myeloid cells, including monocytes, dendritic cells, and microglia. The TREM family members are cell surface glycoproteins with an immunoglobulin-like extracellular domain, a transmembrane region and a short cytoplasmic tail region. The present article reviews the following: (1) the structure, function, and variant site analysis of the Trem2 gene; (2) the metabolism of TREM2 in peripheral blood and cerebrospinal fluid; and (3) the possible underlying mechanism by which TREM2 regulates innate immunity and participates in AD.

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References 72 · Cited by 76

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Authors
Li, J.-T., & Zhang, Y.
Affiliations
Beijing Jiaotong University (CN)
Corresponding author
Zhang, Ying
ORCID
Zhang, Ying
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2018-04-14
Volume
15
Issue
1
Pages
107-107
ISSN
1742-2094 (ISSN-L)
DOI
10.1186/s12974-018-1148-y
PMC
PMC5899410
OpenAlex
W2800856200
Cited by
76
References
72
Citations by year
2026: 5 · 2025: 9 · 2024: 8 · 2023: 10 · 2022: 7 · 2021: 12 · 2020: 13 · 2019: 7 · 2018: 5
FWCI
0.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (81100809 and 81271417)
  • Beijing Municipal Natural Science Foundation (7152090)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Immunology and Microbiology › Immunology › Inflammation biomarkers and pathways
Keywords
TREM2, Alzheimer's disease, microglia, innate immunity, cerebrospinal fluid, neuroinflammation
MeSH terms
Alzheimer Disease, Humans, Immunity, Innate, Membrane Glycoproteins, Receptors, Immunologic

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