Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease
Open accessAbstract
The gut microbiota regulates the host immune and nervous systems and plays an important role in the pathogenesis of autoimmune neurological disease multiple sclerosis (MS). There are considerable efforts currently being undertaken to develop therapies for MS based on the modulation of microbiota. Evidence from experimental models suggests that the manipulation of microbiota through diet or antibiotics prior to the disease development limits disease susceptibility. However, it is currently unclear if microbiota manipulation therapies would also have an impact on ongoing neurological disease. Here, we examined the effect of antibiotic-based microbiota modulation in spontaneous experimental autoimmune encephalomyelitis (EAE) mouse models of MS before and after the onset of autoimmune disease. Prophylactic antibiotic treatment led to a significant reduction of susceptibility to spontaneous EAE. In contrast, antibiotic treatment after the onset of spontaneous EAE did not show a significant amelioration. These results reveal that the perturbation of gut bacteria alters disease susceptibility but has minimal impact on the ongoing neurological disease.
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Prophylactic antibiotic treatment before clinical onset of spontaneous experimental autoimmune encephalomyelitis led to a significant reduction of susceptibility, accompanied by altered intestinal microbial composition and a decrease in Th-17 cell development.
“Prophylactic antibiotic treatment (at 1–3 weeks before the clinical onset of the disease, starting from 2–4 weeks of age) led to a significant reduction of susceptibility to spontaneous EAE, accompanied by altered intestinal microbial composition and a decrease in Th-17 cell development (153).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [153]
Antibiotic treatment after the onset of the first signs of spontaneous experimental autoimmune encephalomyelitis did not affect the ongoing disease and CNS inflammation.
“In contrast, antibiotic treatment after the onset of the first signs of spontaneous EAE did not affect the ongoing disease and CNS inflammation (153).”
From The gut-brain axis: how microbiota and host inflammasome influence brain physiology and pathology (2020) · cites this paper as [153]
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References 15 · Cited by 28
- Authors
- Gödel, C., Kunkel, B., Kashani, A., Lassmann, H., Arumugam, M., & Krishnamoorthy, G.
- Affiliations
- University of Freiburg (DE)
- Max Planck Institute of Biochemistry (DE)
- University of Copenhagen (DK)
- Medical University of Vienna (AT)
- Corresponding author
- Krishnamoorthy, Gurumoorthy
- Venue
- Journal of Neuroinflammation
- Published
- 2020-03-06
- Volume
- 17
- Issue
- 1
- Pages
- 79-79
- ISSN
- 1742-2094 (ISSN-L)
- PMC
- PMC7060541
- OpenAlex
- W3012384794
- Cited by
- 28
- References
- 15
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 6 · 2020: 4
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Neuroinflammation (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- European Research Council (635617)
- Deutsche Forschungsgemeinschaft (SFB TR-128 (Project A1))
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- gut microbiota, multiple sclerosis, experimental autoimmune encephalomyelitis, antibiotic therapy, microbiota modulation, disease susceptibility, disease onset, gut-brain axis
- MeSH terms
- Gastrointestinal Microbiome, Animals, Anti-Bacterial Agents, Brain, Disease Susceptibility, Encephalomyelitis, Autoimmune, Experimental, Spinal Cord, Neuroimmunomodulation, Mice
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