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Cited by 67Mosquito-borne diseases and controlInfectious Encephalopathies and EncephalitisViral Infections and Vectors

Neurocognitive impacts of arbovirus infections

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Clé, Marion, Eldin, Patrick, Briant, Laurence, Lannuzel, Annie, Simonin, Yannick, Van de Perre, Philippe, Cabié, André, Salinas, Sara·2020·Journal of Neuroinflammation
DOI 10.1186/s12974-020-01904-3PMC PMC7418199
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Abstract

Arthropod-borne viruses or arbovirus, are most commonly associated with acute infections, resulting on various symptoms ranging from mild fever to more severe disorders such as hemorrhagic fever. Moreover, some arboviral infections can be associated with important neuroinflammation that can trigger neurological disorders including encephalitis, paralysis, ophthalmological impairments, or developmental defects, which in some cases, can lead to long-term defects of the central nervous system (CNS). This is well illustrated in Zika virus-associated congenital brain malformations but also in West Nile virus-induced synaptic dysfunctions that can last well beyond infection and lead to cognitive deficits. Here, we summarize clinical and mechanistic data reporting on cognitive disturbances triggered by arboviral infections, which may highlight growing public health issues spanning the five continents.

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  • Neuroinflammation is a common hallmark for both AD and CNS infections.

    “Neuroinflammation is a common hallmark for both AD and CNS infections (Cle et al., 2020).”

    From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Cle et al., 2020

    The clinical-perspective section describes neuroinflammation in arboviral CNS infections, and the Conclusions call it a key mechanism in various neuronal disorders. The paper mentions Alzheimer’s disease and cites work on microglia-mediated synapse loss in AD, but it does not establish neuroinflammation as a hallmark of AD specifically. (LLM, conf=0.82)

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Authors
Clé, M., Eldin, P., Briant, L., Lannuzel, A., Simonin, Y., Van de Perre, P., Cabié, A., & Salinas, S.
Affiliations
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Salinas, Sara
ORCID
Venue
Journal of Neuroinflammation
Publisher
Springer Science and Business Media LLC
Published
2020-08-10
Volume
17
Issue
1
Pages
233-233
ISSN
1742-2094 (ISSN-L)
DOI
10.1186/s12974-020-01904-3
PMC
PMC7418199
OpenAlex
W3048695505
Cited by
67
References
205
Citations by year
2026: 8 · 2025: 11 · 2024: 17 · 2023: 11 · 2022: 12 · 2021: 7 · 2020: 1
FWCI
1.30
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroinflammation (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • HAL (submittedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Agence Nationale de la Recherche (ANR-16-IDEX-0006, ANR-10-LABX-12-01)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Mosquito-borne diseases and control
  • Health Sciences › Medicine › Infectious Diseases › Infectious Encephalopathies and Encephalitis
  • Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
Keywords
arbovirus infection, arboviruses, neurocognitive impairment, neuroinflammation, Zika virus, congenital brain malformation, West Nile virus, synaptic dysfunction, cognitive impairment, encephalitis, hemorrhagic fever, long-term neurological sequelae
MeSH terms
Arbovirus Infections, Cognition, Cognition Disorders, Humans

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