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Cited by 324Glaucoma and retinal disordersNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments

Solving neurodegeneration: common mechanisms and strategies for new treatments

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Wareham, Lauren K., Liddelow, Shane A., Temple, Sally, Benowitz, Larry I., Di Polo, Adriana, Wellington, Cheryl, Goldberg, Jeffrey L., He, Zhigang +13 more·2022·Molecular Neurodegeneration
DOI 10.1186/s13024-022-00524-0PMC PMC8935795
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Abstract

Across neurodegenerative diseases, common mechanisms may reveal novel therapeutic targets based on neuronal protection, repair, or regeneration, independent of etiology or site of disease pathology. To address these mechanisms and discuss emerging treatments, in April, 2021, Glaucoma Research Foundation, BrightFocus Foundation, and the Melza M. and Frank Theodore Barr Foundation collaborated to bring together key opinion leaders and experts in the field of neurodegenerative disease for a virtual meeting titled “Solving Neurodegeneration”. This “think-tank” style meeting focused on uncovering common mechanistic roots of neurodegenerative disease and promising targets for new treatments, catalyzed by the goal of finding new treatments for glaucoma, the world’s leading cause of irreversible blindness and the common interest of the three hosting foundations. Glaucoma, which causes vision loss through degeneration of the optic nerve, likely shares early cellular and molecular events with other neurodegenerative diseases of the central nervous system. Here we discuss major areas of mechanistic overlap between neurodegenerative diseases of the central nervous system: neuroinflammation, bioenergetics and metabolism, genetic contributions, and neurovascular interactions. We summarize important discussion points with emphasis on the research areas that are most innovative and promising in the treatment of neurodegeneration yet require further development. The research that is highlighted provides unique opportunities for collaboration that will lead to efforts in preventing neurodegeneration and ultimately vision loss.

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  • Neurological disorders, namely neurodegeneration and acute CNS injury, are overwhelmingly difficult to treat and cure.

    “Neurological disorders, namely neurodegeneration and acute CNS injury, are overwhelmingly difficult maladies to treat and cure [101].”

    From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [101]

    The Conclusions (‘The challenge ahead’) call effective treatment or prevention of neurodegenerative disease a monumental challenge. ‘The promise of regeneration’ says the CNS has very limited capacity to repair itself after injury, but the paper does not specifically establish the claim about treating and curing acute CNS injury. (LLM, conf=0.82)

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Authors
Wareham, L. K., Liddelow, S. A., Temple, S., Benowitz, L. I., Di Polo, A., Wellington, C., Goldberg, J. L., He, Z., Duan, X., Bu, G., Davis, A. A., Shekhar, K., Torre, A. L., Chan, D. C., Canto-Soler, M. V., Flanagan, J. G., Subramanian, P., Rossi, S., Brunner, T., Bovenkamp, D. E., & Calkins, D. J.
Affiliations
  • Vanderbilt University (US)
  • New York University (US)
  • Neural Stem Cell Institute (US)
  • Boston Children's Hospital (US)
  • University of British Columbia (CA)
  • Stanford University (US)
  • University of California, San Francisco (US)
  • Mayo Clinic in Florida (US)
  • Washington University in St. Louis (US)
  • University of California, Berkeley (US)
  • University of California, Davis (US)
  • California Institute of Technology (US)
  • University of Colorado Anschutz (US)
  • BrightFocus Foundation (US)
  • Glaucoma Research Foundation (US)
Corresponding author
Calkins, David J.
ORCID
Venue
Molecular Neurodegeneration
Publisher
Springer Science and Business Media LLC
Published
2022-03-21
Volume
17
Issue
1
Pages
23-23
ISSN
1750-1326 (ISSN-L)
DOI
10.1186/s13024-022-00524-0
PMC
PMC8935795
OpenAlex
W4220937678
Cited by
324
References
306
Citations by year
2026: 58 · 2025: 108 · 2024: 83 · 2023: 51 · 2022: 22 · 2015: 1 · 2012: 1
FWCI
14.13
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular Neurodegeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • CaltechAUTHORS (California Institute of Technology) (submittedVersion, cc-by)
  • Digital Commons@Becker (Washington University School of Medicine) (submittedVersion, cc-by)
  • cIRcle (University of British Columbia) (submittedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • Minerva Access (University of Melbourne) (submittedVersion, cc-by)
  • Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
  • Open Collections
Funders
  • Glaucoma Research Foundation (Glaucoma Research Foundation)
  • BrightFocus Foundation (BrightFocus Foundation)
  • Melza M. and Frank Theodore Barr Foundation (Melza M. and Frank Theodore Barr Foundation)
Topics
  • Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Keywords
neurodegeneration, glaucoma, neuroinflammation, neurovascular interactions, neuroprotection, optic nerve degeneration, vision loss, therapeutic target, neurodegeneration prevention
MeSH terms
Neuroprotection, Glaucoma, Humans, Optic Nerve, Neurodegenerative Diseases

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