The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development
Open accessAbstract
Anlotinib is a new, orally administered tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptors (PDGFR), and c-kit. Compared to the effect of placebo, it improved both progression-free survival (PFS) and overall survival (OS) in a phase III trial in patients with advanced non-small-cell lung cancer (NSCLC), despite progression of the cancer after two lines of prior treatments. Recently, the China Food and Drug Administration (CFDA) approved single agent anlotinib as a third-line treatment for patients with advanced NSCLC. Moreover, a randomized phase IIB trial demonstrated that anlotinib significantly prolonged the median PFS in patients with advanced soft tissue sarcoma (STS). Anlotinib also showed promising efficacy in patients with advanced medullary thyroid carcinoma and metastatic renal cell carcinoma (mRCC). The tolerability profile of anlotinib is similar to that of other tyrosine kinase inhibitors that target VEGFR and other tyrosine kinase-mediated pathways; however, anlotinib has a significantly lower incidence of grade 3 or higher side effects compared to that of sunitinib. We review the rationale, clinical evidence, and future perspectives of anlotinib for the treatment of multiple cancers.
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Cites
Sunitinib versus Interferon Alfa in Metastatic Renal-Cell Carcinoma
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Casali, P. G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J. V. M. G., Brodowicz, T., Broto, J. M., et al. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy096 · Cited by 1,614
Combining immunotherapy and targeted therapies in cancer treatment
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Cited by
Phase 1b Study of Sintilimab Plus Anlotinib as First-line Therapy in Patients With Advanced NSCLC
Chu, T., Zhong, R., Zhong, H., Zhang, B., Zhang, W., Shi, C., Qian, J., Zhang, Y., Chang, Q., Zhang, X., et al. (2021) · Journal of Thoracic Oncology · doi:10.1016/j.jtho.2020.11.026 · Cited by 227
Liang, L., Hui, K., Hu, C., Wen, Y., Yang, S., Zhu, P., Wang, L., Xia, Y., Qiao, Y., Sun, W., et al. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1093-3 · Cited by 187
Self-citationJiang, Q., Huang, J., Zhang, B., Li, X., Chen, X., Cui, B., Li, S., & Guo, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.801909 · Cited by 11
Metadata
- Authors
- Shen, G., Zheng, F., Ren, D., Du, F., Dong, Q., Wang, Z., Zhao, F., Ahmad, R., & Zhao, J.
- Venue
- Journal of Hematology & Oncology
- Published
- 2018-09-19
- Volume
- 11
- Issue
- 1
- Pages
- 120-120
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W2889570909
- Cited by
- 658
- References
- 47
- FWCI
- 22.66
- Type
- journal article
- Language
- en
- Open access
- gold
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- Shen, G., Zheng, F., Ren, D., Du, F., Dong, Q., Wang, Z., Zhao, F., Ahmad, R., & Zhao, J. (2018). Anlotinib: a novel multi-targeting tyrosine kinase inhibitor in clinical development. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-018-0664-7
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