The DOI matches its Crossref record; 434 of the 434 references it cites were found in a registry or an index.
Ferroptosis: principles and significance in health and disease
Open accessAbstract
Ferroptosis, an iron-dependent form of cell death characterized by uncontrolled lipid peroxidation, is governed by molecular networks involving diverse molecules and organelles. Since its recognition as a non-apoptotic cell death pathway in 2012, ferroptosis has emerged as a crucial mechanism in numerous physiological and pathological contexts, leading to significant therapeutic advancements across a wide range of diseases. This review summarizes the fundamental molecular mechanisms and regulatory pathways underlying ferroptosis, including both GPX4-dependent and -independent antioxidant mechanisms. Additionally, we examine the involvement of ferroptosis in various pathological conditions, including cancer, neurodegenerative diseases, sepsis, ischemia–reperfusion injury, autoimmune disorders, and metabolic disorders. Specifically, we explore the role of ferroptosis in response to chemotherapy, radiotherapy, immunotherapy, nanotherapy, and targeted therapy. Furthermore, we discuss pharmacological strategies for modulating ferroptosis and potential biomarkers for monitoring this process. Lastly, we elucidate the interplay between ferroptosis and other forms of regulated cell death. Such insights hold promise for advancing our understanding of ferroptosis in the context of human health and disease.
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1 retracted
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Self-citationRetractedFerroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
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Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics
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Ferroptosis: mechanisms, biology and role in disease
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Self-citationCopper induces cell death by targeting lipoylated TCA cycle proteins
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Mechanisms of NAFLD development and therapeutic strategies
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ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Ferroptosis: molecular mechanisms and health implications
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Self-citation
Cited by
Ege, S., Akduman, H., Aşir, A., Korak, T., & Aşir, F. (2025) · Medicine · doi:10.1097/md.0000000000044330 · Cited by 3
Metadata
- Authors
- Chen, F., Kang, R., Tang, D., & Liu, J.
- Venue
- Journal of Hematology & Oncology
- Published
- 2024-06-06
- Volume
- 17
- Issue
- 1
- Pages
- 41-41
- ISSN
- 1756-8722 (ISSN-L)
- OpenAlex
- W4399391478
- Cited by
- 285
- References
- 434
- FWCI
- 72.72
- Type
- journal article
- Language
- en
- Open access
- gold
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- Chen, F., Kang, R., Tang, D., & Liu, J. (2024). Ferroptosis: principles and significance in health and disease. Journal of Hematology & Oncology. https://doi.org/10.1186/s13045-024-01564-3
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
