The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Disulfidptosis: a new target for metabolic cancer therapy
Open accessAbstract
Altered metabolism is a hallmark of cancer and presents a vulnerability that can be exploited in cancer treatment. Regulated cell death (RCD) plays a crucial role in cancer metabolic therapy. A recent study has identified a new metabolic-related RCD known as disulfidptosis. Preclinical findings suggest that metabolic therapy using glucose transporter (GLUT) inhibitors can trigger disulfidptosis and inhibit cancer growth. In this review, we summarize the specific mechanisms underlying disulfidptosis and outline potential future research directions. We also discuss the challenges that may arise in the clinical translation of disulfidptosis research.
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Cites
Copper induces cell death by targeting lipoylated TCA cycle proteins
Tsvetkov, P., Coy, S., Petrova, B., Dreishpoon, M., Verma, A., Abdusamad, M., Rossen, J., Joesch-Cohen, L., Humeidi, R., Spangler, R. D., et al. (2022) · Science · doi:10.1126/science.abf0529 · Cited by 4,932
Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy
Koppula, P., Zhuang, L., & Gan, B. (2021) · Protein & Cell · doi:10.1007/s13238-020-00789-5 · Cited by 2,487
Targeting cancer metabolism in the era of precision oncology
Stine, Z. E., Schug, Z. T., Salvino, J. M., & Dang, C. V. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00339-6 · Cited by 1,189
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis
Liu, X., Nie, L., Zhang, Y., Yan, Y., Wang, C., Colic, M., Olszewski, K., Horbath, A., Chen, X., Lei, G., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01091-2 · Cited by 1,132
Liu, X., Olszewski, K., Zhang, Y., Lim, E. W., Shi, J., Zhang, X., Zhang, J., Lee, H., Koppula, P., Lei, G., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0496-x · Cited by 589
Metadata
- Authors
- Zheng, P., Zhou, C., Ding, Y., & Duan, S.
- Venue
- Journal of Experimental & Clinical Cancer Research
- Published
- 2023-04-27
- Volume
- 42
- Issue
- 1
- Pages
- 103-103
- ISSN
- 0392-9078 (ISSN-L)
- 1756-9966
- OpenAlex
- W4367059833
- Cited by
- 281
- References
- 5
- FWCI
- 46.07
- Type
- journal article
- Language
- en
- Open access
- gold
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- Zheng, P., Zhou, C., Ding, Y., & Duan, S. (2023). Disulfidptosis: a new target for metabolic cancer therapy. Journal of Experimental & Clinical Cancer Research. https://doi.org/10.1186/s13046-023-02675-4
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
