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Pre-hospital extra-corporeal cardiopulmonary resuscitation
Open accessAbstract
Survival from out-of-hospital cardiac arrest (OHCA) has remained low despite advances in resuscitation science. Hospital-based extra-corporeal cardiopulmonary resuscitation (ECPR) is a novel use of an established technology that provides greater blood flow and oxygen delivery during cardiac arrest than closed chest compressions. Hospital-based ECPR is currently offered to selected OHCA patients in specialized centres. The interval between collapse and restoration of circulation is inversely associated with good clinical outcomes after ECPR. Pre-hospital delivery of ECPR concurrent with conventional resuscitation is one approach to shortening this interval and improving outcomes after OHCA. This article examines the background and rationale for pre-hospital ECPR; summarises the findings of a literature search for published evidence; and considers candidate selection, logistics, and complications for this complex intervention.
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- Berdowski J, Berg RA, Tijssen JG, Koster RW. Global incidences of out-of-hosital cardiac arrest and survival rates: systematic review of 67 prospective studies. Resuscitation. 2010;81(11):1479–87. · DOI
- Sanders AB, et al. Coronary perfusion pressure during cardiopulmonary resuscitation. Am J Emerg Med. 1985;3(1):11–4. · DOI
- Paradis NA, et al. Coronary perfusion pressure and the return of spontaneous circulation in human cardiopulmonary resuscitation. JAMA. 1990;263(8):1106–13. · DOI
- Delguercio LR, et al. Comparison of blood flow during external and internal cardiac massage in man. Circulation. 1965;31(SUPPL 1):171–80.
- Kuroki N, et al. Association between delay to coronary reperfusion and outcome in patients with acute coronary syndrome undergoing extracorporeal cardiopulmonary resuscitation. Resuscitation. 2017;114:1–6. · DOI
- Ahn C, et al. Efficacy of extracorporeal cardiopulmonary resuscitation compared to conventional cardiopulmonary resuscitation for adult cardiac arrest patients: a systematic review and meta-analysis. Sci Rep. 2016;6:34208. · DOI
- Wang GN, et al. Comparison of extracorporeal and conventional cardiopulmonary resuscitation: a meta-analysis of 2 260 patients with cardiac arrest. World J Emerg Med. 2017;8(1):5–11. · DOI
- Richardson AS, et al. ECMO cardio-pulmonary resuscitation (ECPR), trends in survival from an international multicentre cohort study over 12-years. Resuscitation. 2017; Mar;112:34–40. · DOI
- Debaty G, et al. Prognostic factors for extracorporeal cardiopulmonary resuscitation recipients following out-of-hospital refractory cardiac arrest. A systematic review and meta-analysis. Resuscitation. 2017;112:1–10. · DOI
- Rousse N, et al. Extracorporeal life support in out-of-hospital refractory cardiac arrest. Artif Organs. 2016;40(9):904–9. · DOI
- Fjolner J, et al. Extracorporeal cardiopulmonary resuscitation after out-of-hospital cardiac arrest in a Danish health region. Acta Anaesthesiol Scand. 2017;61(2):176–85. · DOI
- Wallmuller C, et al. Emergency cardio-pulmonary bypass in cardiac arrest: seventeen years of experience. Resuscitation. 2013;84(3):326–30. · DOI
- Megarbane B, et al. Usefulness of routine laboratory parameters in the decision to treat refractory cardiac arrest with extracorporeal life support. Resuscitation. 2011;82(9):1154–61. · DOI
- Belle L, Manguin L, Bonnet H, Fol S, Santre C, Delavenat L, Savary D, Bougon D, Vialle E, Dompnier A, Desjoyaux E, Blin D. Emergency extracorporeal membrane oxygenation in a hospital without on-site cardiac surgeon. Eur Secur. 2012;8(3) · DOI
- Bailey ED, Wydro GC, Cone DC. Termination of resuscitation in the prehospital setting for adult patients suffering nontraumatic cardiac arrest. National Association of EMS physicians standards and clinical practice committee. Prehosp Emerg Care. 2000;4:190–5. · DOI
- Millin MG, Khandker SR, Maliki A. Termination of resuscitation of nontraumatic cardiopulmonary arrest: resource document for the National Association of EMS physicians position statement. Prehosp Emerg Care. 2011. 15: p. 547–554. doi: https://doi.org/10.3109/10903127.2011.608872 . Epub 15 Aug 2011. · DOI
- Grunau B, et al. Relationship between time-to-ROSC and survival in out-of-hospital cardiac arrest ECPR candidates: when is the best time to consider transport to hospital? Prehosp Emerg Care. 2016;20(5):615–22. · DOI
- Reynolds JC, et al. Prevalence, natural history, and time-dependent outcomes of a multi-center north American cohort of out-of-hospital cardiac arrest extracorporeal CPR candidates. Resuscitation. 2017;117:24–31. · DOI
- Olasveengen TM, Wik L, Steen PA. Quality of cardiopulmonary resuscitation before and during transport in out-of-hospital cardiac arrest. Resuscitation. 2008;76(2):185–90. · DOI
- Zive D, et al. Variation in out-of-hospital cardiac arrest resuscitation and transport practices in the resuscitation outcomes consortium: ROC Epistry-cardiac arrest. Resuscitation. 2011;82(3):277–84. · DOI
- Drennan IR, et al. Resuscitation outcomes consortium investigators. A comparison of the universal TOR guideline to the absence of prehospital ROSC and duration of resuscitation in predicting futility from out-of-hospital cardiac arrest. Resuscitation. 2017; Feb;111:96–102. · DOI
- Wagner H, et al. Cardiac arrest in the catheterisation laboratory: a 5-year experience of using mechanical chest compressions to facilitate PCI during prolonged resuscitation efforts. Resuscitation. 2010;81(4):383–7. · DOI
- Fagnoul D, Combes A, De Backer D. Extracorporeal cardiopulmonary resuscitation. Curr Opin Crit Care. 2014;20(3):259–65. · DOI
- Stub D, et al. Refractory cardiac arrest treated with mechanical CPR, hypothermia, ECMO and early reperfusion (the CHEER trial). Resuscitation. 2015;86:88–94. · DOI
- Lamhaut L, et al. A pre-hospital extracorporeal cardio pulmonary resuscitation (ECPR) strategy for treatment of refractory out hospital cardiac arrest: an observational study and propensity analysis. Resuscitation. 2017; · DOI
- Andersen LW, et al. The relationship between age and outcome in out-of-hospital cardiac arrest patients. Resuscitation. 2015;94:49–54. · DOI
- Chen YS, et al. Cardiopulmonary resuscitation with assisted extracorporeal life-support versus conventional cardiopulmonary resuscitation in adults with in-hospital cardiac arrest: an observational study and propensity analysis. Lancet. 2008;372(9638):554–61. · DOI
- Cho YS, et al. Five-year experience of extracorporeal life support in emergency physicians. The Korean Journal of Critical Care Medicine. 2017;32(1):52–9. · DOI
- Choi DH, et al. Extracorporeal cardiopulmonary resuscitation among patients with out-of-hospital cardiac arrest. Clin Exp Emerg Med. 2016;3(3):132–8. · DOI
- Lasa JJ, Rogers RS, Localio R, et al. Extracorporeal cardiopulmonary resuscitation (E-CPR) during pediatric in-hospital cardiopulmonary arrest is associated with improved survival to discharge: a report from the american heart association’s get with the guidelines-resuscitation (GWTG-R) registry. Circulation. 2016;133:165–76. · DOI
- Kane DA, Thiagarajan RR, Wypij D, et al. Rapid-response extracorporeal membrane oxygenation to support cardiopulmonary resuscitation in children with cardiac disease. Circulation. 2010;122:S241–8. · DOI
- Hasselqvist-Ax I, et al. Early cardiopulmonary resuscitation in out-of-hospital cardiac arrest. N Engl J Med. 2015;372(24):2307–15. · DOI
- Sekhon MS, Ainslie PN, Griesdale DE. Clinical pathophysiology of hypoxic ischemic brain injury after cardiac arrest: a "two-hit" model. Crit Care. 2017;21(1):90. · DOI
- Jeong WJ, et al. Extracorporeal cardiopulmonary resuscitation in bedside echocardiography-diagnosed massive pulmonary embolism. Am J Emerg Med, 2015 33(10): p. 1545:e1–2. · DOI
- Seiji Morita SI, Yamagiwa T, Lizuka S, Yamamoto R, Aoki H, Okada M. Efficacy of portable and Percutnaeous cardiopulmonary bypass rewarming versus that of conventional internal rewarming for patients with accidental deep hypothermia. Crit Care Med. 2011;39(5):1064–8. · DOI
- Wengenmayer T, et al. Influence of low-flow time on survival after extracorporeal cardiopulmonary resuscitation (eCPR). Crit Care. 2017;21(1):157. · DOI
- Bellezzo JM, et al. Emergency physician-initiated extracorporeal cardiopulmonary resuscitation. Resuscitation. 2012;83(8):966–70. · DOI
- Belohlavek J, et al. Hyperinvasive approach to out-of hospital cardiac arrest using mechanical chest compression device, prehospital intraarrest cooling, extracorporeal life support and early invasive assessment compared to standard of care. A randomized parallel groups comparative study proposal. "Prague OHCA study". J Transl Med. 2012;10:163. · DOI
- Brouwer TF, et al. Association Between Chest Compression Interruptions and Clinical Outcomes of Ventricular Fibrillation Out-of-Hospital Cardiac Arrest. Circulation. 2015;132(11):1030–7. · DOI
- Reynolds JC, et al. Association between duration of resuscitation and favorable outcome after out-of-hospital cardiac arrest: implications for prolonging or terminating resuscitation. Circulation. 2016;134(25):2084–94. · DOI
- Kim SJ, et al. An optimal transition time to extracorporeal cardiopulmonary resuscitation for predicting good neurological outcome in patients with out-of-hospital cardiac arrest: a propensity-matched study. Crit Care. 2014;18(5):535. · DOI
- Lamhaut L, et al. Safety and feasibility of prehospital extra corporeal life support implementation by non-surgeons for out-of-hospital refractory cardiac arrest. Resuscitation. 2013;84(11):1525–9. · DOI
- Arlt M, et al. Out-of-hospital extracorporeal life support for cardiac arrest-a case report. Resuscitation. 2011;82(9):1243–5. · DOI
- Lebreton G, et al. Out-of-hospital extra-corporeal life support implantation during refractory cardiac arrest in a half-marathon runner. Resuscitation. 2011;82(9):1239–42. · DOI
- Lamhaut L, et al. Successful treatment of refractory cardiac arrest by emergency physicians using pre-hospital ECLS. Resuscitation. 2012 Aug;83(8):e117–8. · DOI
- Hilker, M., et al., Pre-hospital cardiopulmonary resuscitation supported by ECMO – a case series of 6 patients, in 42nd Annual Meeting of the German Scoeity for Cardiovascular and Thoracic Surgery. 2013: Freiburg. p. p$%. · DOI
- Lamhaut L, et al. Extracorporeal cardiopulmonary resuscitation (ECPR) in the prehospital setting: an illustrative case of ECPR performed in the louvre museum. Prehosp Emerg Care. 2017;21(3):386–9. · DOI
- Lee DS, et al. Survival after extracorporeal cardiopulmonary resuscitation on weekends in comparison with weekdays. Ann Thorac Surg. 2016;101(1):133–40. · DOI
- Avalli L, et al. Favourable survival of in-hospital compared to out-of-hospital refractory cardiac arrest patients treated with extracorporeal membrane oxygenation: an Italian tertiary care Centre experience. Resuscitation. 2012;83(5):579–83. · DOI
- Aubron C, et al. Infections acquired by adults who receive extracorporeal membrane oxygenation: risk factors and outcome. Infect Control Hosp Epidemiol. 2013;34(1):24–30. · DOI
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European Resuscitation Council Guidelines 2021: Ethics of resuscitation and end of life decisions
Mentzelopoulos, S. D., Couper, K., Voorde, P. V. D., Druwé, P., Blom, M., Perkins, G. D., Lulic, I., Djakow, J., Raffay, V., Lilja, G., et al. (2021) · Resuscitation · doi:10.1016/j.resuscitation.2021.02.017 · Cited by 246
Metadata
- Authors
- Singer, B., Reynolds, J. C., Lockey, D. J., & O’Brien, B.
- Affiliations
- St Bartholomew's Hospital (GB)
- Michigan State University (US)
- Queen Mary University of London (GB)
- Corresponding author
- Singer, Ben
- Venue
- Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
- Published
- 2018-03-27
- Volume
- 26
- Issue
- 1
- Pages
- 21-21
- ISSN
- 1757-7241 (ISSN-L)
- PMC
- PMC5870373
- OpenAlex
- W2804007779
- Cited by
- 58
- References
- 0
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 12 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 2
- FWCI
- 1.44
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scandinavian Journal of Trauma Resuscitation and Emergency Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Emergency Medicine › Cardiac Arrest and Resuscitation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Mechanical Circulatory Support Devices
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Palliative Care and End-of-Life Issues
- Keywords
- out-of-hospital cardiac arrest, extracorporeal cardiopulmonary resuscitation, prehospital care, candidate selection, survival after cardiac arrest
- MeSH terms
- Emergency Medical Services, Humans, Extracorporeal Membrane Oxygenation, Cardiopulmonary Resuscitation, Out-of-Hospital Cardiac Arrest
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