The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature
Open accessAbstract
BACKGROUND: Sepsis is a common condition encountered by emergency and critical care physicians, with significant costs, both economic and human. Myocardial dysfunction in sepsis is a well-recognized but poorly understood phenomenon. There is an extensive body of literature on this subject, yet results are conflicting and no objective definition of septic cardiomyopathy exists, representing a critical knowledge gap. OBJECTIVES: In this article, we review the pathophysiology of septic cardiomyopathy, covering the effects of key inflammatory mediators on both the heart and the peripheral vasculature, highlighting the interconnectedness of these two systems. We focus on the extant literature on echocardiographic and laboratory assessment of the heart in sepsis, highlighting gaps therein and suggesting avenues for future research. Implications for treatment are briefly discussed. CONCLUSIONS: As a result of conflicting data, echocardiographic measures of left ventricular (systolic or diastolic) or right ventricular function cannot currently provide reliable prognostic information in patients with sepsis. Natriuretic peptides and cardiac troponins are of similarly unclear utility. Heterogeneous classification of illness, treatment variability, and lack of formal diagnostic criteria for septic cardiomyopathy contribute to the conflicting results. Development of formal diagnostic criteria, and use thereof in future studies, may help elucidate the link between cardiac performance and outcomes in patients with sepsis.
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Lang, R. M., Badano, L. P., Mor-Avi, V., Afilalo, J., Armstrong, A., Ernande, L., Flachskampf, F. A., Foster, E., Goldstein, S. A., Kuznetsova, T., et al. (2015) · European Heart Journal – Cardiovascular Imaging · doi:10.1093/ehjci/jev014 · Cited by 8,361
GRADE guidelines: 3. Rating the quality of evidence
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Comparison of Two Fluid-Management Strategies in Acute Lung Injury
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Profound but Reversible Myocardial Depression in Patients with Septic Shock
PARKER, M. M., SHELHAMER, J. H., BACHARACH, S. L., GREEN, M. V., NATANSON, C., FREDERICK, T. M., DAMSKE, B. A., & PARRILLO, J. E. (1984) · Annals of Internal Medicine · doi:10.7326/0003-4819-100-4-483 · Cited by 1,585
Tricuspid Annular Displacement Predicts Survival in Pulmonary Hypertension
Forfia, P. R., Fisher, M. R., Mathai, S. C., Housten-Harris, T., Hemnes, A. R., Borlaug, B. A., Chamera, E., Corretti, M. C., Champion, H. C., Abraham, T. P., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200604-547oc · Cited by 1,090
B-type natriuretic peptide in cardiovascular disease
de Lemos, J. A., McGuire, D. K., & Drazner, M. H. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13976-1 · Cited by 1,067
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Metadata
- Authors
- Ehrman, R. R., Sullivan, A. N., Favot, M. J., Sherwin, R. L., Reynolds, C. A., Abidov, A., & Levy, P. D.
- Venue
- Critical Care
- Published
- 2018-05-04
- Volume
- 22
- Issue
- 1
- Pages
- 112-112
- ISSN
- 1364-8535 (ISSN-L)
- OpenAlex
- W2805299785
- Cited by
- 284
- References
- 70
- FWCI
- 13.13
- Type
- journal article
- Language
- en
- Open access
- gold
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- CoChat. (2026). Citation check: Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. https://app.cochat.ai/papers/10.1186/s13054-018-2043-8
- The paper
- Ehrman, R. R., Sullivan, A. N., Favot, M. J., Sherwin, R. L., Reynolds, C. A., Abidov, A., & Levy, P. D. (2018). Pathophysiology, echocardiographic evaluation, biomarker findings, and prognostic implications of septic cardiomyopathy: a review of the literature. Critical Care. https://doi.org/10.1186/s13054-018-2043-8
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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