The DOI matches its Crossref record; 62 of the 62 references it cites were found in a registry or an index.
Bipartite structure of the inactive mouse X chromosome
Open accessAbstract
Background: In mammals, one of the female X chromosomes and all imprinted genes are expressed exclusively from a single allele in somatic cells. To evaluate structural changes associated with allelic silencing, we have applied a recently developed Hi-C assay that uses DNase I for chromatin fragmentation to mouse F1 hybrid systems. Results: We find radically different conformations for the two female mouse X chromosomes. The inactive X has two superdomains of frequent intrachromosomal contacts separated by a boundary region. Comparison with the recently reported two-superdomain structure of the human inactive X shows that the genomic content of the superdomains differs between species, but part of the boundary region is conserved and located near the Dxz4 / DXZ4 locus. In mouse, the boundary region also contains a minisatellite, Ds-TR , and both Dxz4 and Ds-TR appear to be anchored to the nucleolus. Genes that escape X inactivation do not cluster but are located near the periphery of the 3D structure, as are regions enriched in CTCF or RNA polymerase. Fewer short-range intrachromosomal contacts are detected for the inactive alleles of genes subject to X inactivation compared with the active alleles and with genes that escape X inactivation. This pattern is also evident for imprinted genes, in which more chromatin contacts are detected for the expressed allele. Conclusions: By applying a novel Hi-C method to map allelic chromatin contacts, we discover a specific bipartite organization of the mouse inactive X chromosome that probably plays an important role in maintenance of gene silencing.
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Organization and function of the 3D genome
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Spatially resolved epigenomic profiling of single cells in complex tissues
Lu, T., Ang, C. E., & Zhuang, X. (2022) · Cell · doi:10.1016/j.cell.2022.09.035 · Cited by 197
Metadata
- Authors
- Deng, X., Ma, W., Ramani, V., Hill, A., Yang, F., Ay, F., Berletch, J. B., Blau, C. A., Shendure, J., Duan, Z., Noble, W. S., & Disteche, C. M.
- Venue
- Genome Biology
- Published
- 2015-08-07
- Volume
- 16
- Issue
- 1
- Pages
- 152-152
- ISSN
- 1465-6906 (ISSN-L)
- 1474-760X
- OpenAlex
- W1783209592
- Cited by
- 259
- References
- 62
- FWCI
- 11.32
- Type
- journal article
- Language
- en
- Open access
- gold
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