A new and efficient synthesis of substituted 2-amino-1,3,4-oxadiazoles from isothiocyanates and hydrazides
Open accessAbstract
1,3,4-Oxadiazoles are privileged heterocyclic scaffolds with broad bioactivities, holding significant importance in pharmaceutical and agrochemical discovery. Herein, we report a novel, efficient, and simple synthetic route to 2-amino-1,3,4-oxadiazoles via NaOH-mediated desulfurative cyclization of hydrazides and isothiocyanates under mild reaction conditions. This developed methodology features broad substrate tolerance, excellent yields, operational simplicity, and mild conditions, providing a straightforward pathway for versatile syntheses of valuable 1,3,4-oxadiazole derivative. Consequently, the present reaction opens an alternative path for the preparation of 1,3,4-oxadiazoles via regioselective cyclization hydrazides and isothiocyanates.
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References 29
- Authors
- Wu, L., Tian, H., Zhang, Y., Ma, W., Zhang, Q., Chen, R., & Chen, X.
- Affiliations
- Luliang University (CN)
- Changzhi Medical College (CN)
- Hubei University of Science and Technology (CN)
- Corresponding author
- Chen, Ruiling
- Chen, Xiuling
- Venue
- BMC Chemistry
- Published
- 2026-06-21
- Volume
- 20
- Issue
- 1
- ISSN
- 2661-801X (ISSN-L)
- PMC
- PMC13536576
- OpenAlex
- W7165477626
- Cited by
- 0
- References
- 29
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMC Chemistry (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Figshare (cc-by)
- Funders
- Guangdong University of Petrochemical Technology
- National Natural Science Foundation of China (22378102)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Structural and Chemical Analysis of Organic and Inorganic Compounds
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Reactions of Organic Compounds
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and Reactivity of Sulfur-Containing Compounds
- Keywords
- 2-amino-1,3,4-oxadiazoles, 1,3,4-oxadiazoles, isothiocyanates, hydrazides, regioselective cyclization, heterocyclic synthesis, nitrogen heterocycles
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