High-throughput sequencing insights into T-cell receptor repertoire diversity in aging
Open accessAbstract
Decline in T-cell generation leading to T-cell receptor repertoire contraction is a cornerstone of immune system aging, and consequent disorders. High-throughput sequencing enables in-depth immune repertoire characterization, but blood samples are too small to capture its total diversity. New computational models could enable accurate estimation of this diversity.
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The distribution of TCR frequencies in an analyzed sample may not reflect the entire repertoire and likely changes with age, which hampers inferential estimates of overall richness.
“The distribution of TCR frequencies in the analyzed sample does not necessarily reflect the distribution in the entire repertoire; moreover, the distribution is likely to change with age, hampering inferential estimates of overall richness”
From Successful and Maladaptive T Cell Aging (2017) · cites this paper as Goronzy et al., 2015
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References 10 · Cited by 36
- Authors
- Goronzy, J. J., Qi, Q., Olshen, R. A., & Weyand, C. M.
- Affiliations
- VA Palo Alto Health Care System (US)
- Stanford Medicine (US)
- Corresponding author
- Goronzy, Jörg J.
- Venue
- Genome Medicine
- Published
- 2015-11-19
- Volume
- 7
- Issue
- 1
- Pages
- 117-117
- ISSN
- 1756-994X (ISSN-L)
- PMC
- PMC4652363
- OpenAlex
- W2177185955
- Cited by
- 36
- References
- 10
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 5 · 2021: 2 · 2019: 6 · 2018: 6 · 2017: 4 · 2016: 6
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG045779)
- National Institute of Allergy and Infectious Diseases (AI057266, AI090019, AI108891, AI108906)
- National Heart, Lung, and Blood Institute (HL117913)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Physical Sciences › Engineering › Biomedical Engineering › Artificial Immune Systems Applications
- Keywords
- T cell receptor repertoire, immunosenescence, repertoire diversity, diversity estimation, computational model, blood samples
- MeSH terms
- Aging, Animals, Clone Cells, Humans, Receptors, Antigen, T-Cell, T-Lymphocytes, Genetic Variation, Mice, High-Throughput Nucleotide Sequencing
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