The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Synaptic dysfunction in complex psychiatric disorders: from genetics to mechanisms
Open accessAbstract
Breakthroughs on many fronts have provided strong evidence to support synaptic dysfunction as a causal factor for neuropsychiatric diseases. Genetic studies have identified variants implicated in novel biological and synaptic pathways, and animal and patient-derived induced pluripotent stem cell-based models have allowed mechanistic investigations of synaptic dysfunction in pathological processes.
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Synaptic dysfunction and altered synaptic plasticity are closely associated with neurologic and psychiatric disorders.
“Synaptic dysfunction and altered synaptic plasticity are closely associated with neurologic and psychiatric disorders (Goto et al., 2010;Forrest et al., 2018;Wang et al., 2018).”
From Psychedelics and Neural Plasticity: Therapeutic Implications (2022) · cites this paper as Wang et al., 2018
The ‘Synaptic function and dysfunction in the brain’ section links dysregulated synaptic properties and plasticity to complex neuropsychiatric disorders, including schizophrenia and autism spectrum disorder. The paper supports the psychiatric association but does not establish the claim for neurologic disorders broadly. No page number is available in our copy. (LLM, conf=0.83)
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Modelling schizophrenia using human induced pluripotent stem cells
Brennand, K. J., Simone, A., Jou, J., Gelboin-Burkhart, C., Tran, N., Sangar, S., Li, Y., Mu, Y., Chen, G., Yu, D., et al. (2011) · Nature · doi:10.1038/nature09915 · Cited by 1,375
FOXG1-Dependent Dysregulation of GABA/Glutamate Neuron Differentiation in Autism Spectrum Disorders
Mariani, J., Coppola, G., Zhang, P., Abyzov, A., Provini, L., Tomasini, L., Amenduni, M., Szekely, A., Palejev, D., Wilson, M., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.034 · Cited by 1,149
Lui, H., Zhang, J., Makinson, S. R., Cahill, M. K., Kelley, K. W., Huang, H.-Y., Shang, Y., Oldham, M. C., Martens, L. H., Gao, F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.001 · Cited by 729
Synaptic dysregulation in a human iPS cell model of mental disorders
Wen, Z., Nguyen, H. N., Guo, Z., Lalli, M. A., Wang, X., Su, Y., Kim, N.-S., Yoon, K.-J., Shin, J., Zhang, C., et al. (2014) · Nature · doi:10.1038/nature13716 · Cited by 549
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Research works printed but not linked: 7
- Schizophrenia Working Group of the Psychiatric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014;511:421–7. · DOI · Paper page
- Sekar A, Bialas AR, de Rivera H, Davis A, Hammond TR, Kamitaki N, et al. Schizophrenia risk from complex variation of complement component 4. Nature. 2016;530:177–83. · DOI · Paper page
- Petanjek Z, Judaš M, Šimić G, Rašin MR, Uylings HBM, Rakic P, et al. Extraordinary neoteny of synaptic spines in the human prefrontal cortex. PNAS. 2011;108:13281–6. · DOI · Paper page
- Ishizuka K, Fujita Y, Kawabata T, Kimura H, Iwayama Y, Inada T, et al. Rare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders. Transl Psychiatry. 2017;7:e1184. · DOI
- Marchetto MC, Belinson H, Tian Y, Freitas BC, Fu C, Vadodaria K, et al. Altered proliferation and networks in neural cells derived from idiopathic autistic individuals. Mol Psychiatry. 2017;22:820–35. · DOI · Paper page
- Ye F, Kang E, Yu C, Qian X, Jacob F, Yu C, et al. DISC1 regulates neurogenesis via modulating kinetochore attachment of Ndel1/Nde1 during Mitosis. Neuron. 2017;96:1041–54. · DOI
- Kim HJ, Cho MH, Shim WH, Kim JK, Jeon EY, Kim DH, et al. Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects. Mol Psychiatry. 2017;22:1576–84. · DOI · Paper page
Cited by
Sorted by citations
Shaping Neuronal Fate: Functional Heterogeneity of Direct Microglia-Neuron Interactions
Cserép, C., Pósfai, B., & Dénes, Á. (2021) · Neuron · doi:10.1016/j.neuron.2020.11.007 · Cited by 256
Psychedelics and Neural Plasticity: Therapeutic Implications
Grieco, S. F., Castrén, E., Knudsen, G. M., Kwan, A. C., Olson, D. E., Zuo, Y., Holmes, T. C., & Xu, X. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.1121-22.2022 · Cited by 82
“Synaptic dysfunction and altered synaptic plasticity are closely associated with neurologic and psychiatric disorders (Goto et al., 2010; Forrest et al., 2018; Wang et al., 2018).”
Synaptic changes in psychiatric and neurological disorders: State-of-the art of in vivo imaging
Howes, O., Marcinkowska, J., Turkheimer, F. E., & Carr, R. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01943-x · Cited by 34
Reid, K. M., & Brown, G. C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1286474 · Cited by 13
Metadata
- Authors
- Wang, X., Christian, K. M., Song, H., & Ming, G.-L.
- Affiliations
- Shanghai Medical College of Fudan University (CN)
- University of Pennsylvania (US)
- Corresponding author
- Ming, Guo-li
- Venue
- Genome Medicine
- Published
- 2018-01-31
- Volume
- 10
- Issue
- 1
- Pages
- 9-9
- ISSN
- 1756-994X (ISSN-L)
- PMC
- PMC5793422
- OpenAlex
- W2797288945
- Cited by
- 71
- References
- 4
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 11 · 2023: 13 · 2022: 13 · 2021: 13 · 2020: 5 · 2019: 6
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Genome Medicine (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (U19MH106434, R01MH105128, R35NS097370, U19AI131130)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- synaptic dysfunction, mental illness, neuropsychiatric disorders, genetic variants, synaptic pathways, induced pluripotent stem cells, animal models, disease mechanisms
- MeSH terms
- Animals, Mental Disorders, Brain, Humans, Synapses
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