Gut microbiota mediated the therapeutic efficacies and the side effects of prednisone in the treatment of MRL/lpr mice
Open accessAbstract
BACKGROUND: Growing evidences indicate that the alterations in gut microbiota are associated with the efficacy of glucocorticoids (GCs) in the treatment of systemic lupus erythematosus (SLE). However, there is no evidence to prove whether gut microbiota directly mediates the effects of GCs. METHODS: Using the MRL/lpr mice, this study firstly addressed the effects of three doses of prednisone on gut microbiota. Then, this study used fecal microbiota transplantation (FMT) to transfer the gut microbiota of prednisone-treated MRL/lpr mice into the blank MRL/lpr mice to reveal whether the gut microbiota regulated by prednisone had similar therapeutic efficiency and side effects as prednisone. RESULTS: The effects of prednisone on gut microbiota were dose-dependent in the treatment of MRL/lpr mice. After transplantation into MRL/lpr mice, prednisone-regulated gut microbiota could alleviate lupus, which might be due to decreasing Ruminococcus and Alistipes and retaining the abundance of Lactobacillus. However, prednisone-regulated gut microbiota did not exhibit side effects as prednisone. The reason might be that the pathogens upregulated by prednisone could not survive in the MRL/lpr mice as exogenous microbiota, such as Parasutterella, Parabacteroides, and Escherichia-Shigella. CONCLUSIONS: These data demonstrated that the transplantation of gut microbiota may be an effective method to obtain the therapeutic effects of GCs and avoid the side effects of GCs.
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Effects of glucocorticoids on the composition and functioning of the microbiota vary, with some studies indicating disruption and others showing beneficial effects, likely depending on the degree of exposure (dose and period) and the type of glucocorticoid studied.
“Regarding the effects of glucocorticoids on the composition and functioning of the microbiota, some studies have indicated microbiota disruption, while others have shown beneficial effects, which likely depend on the degree of exposure (dose and period) and the type of glucocorticoid studied (434–437)”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [436]
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References 40 · Cited by 52
- Authors
- Wang, M., Zhu, Z., Lin, X., Li, H., Wen, C., Bao, J., & He, Z.
- Affiliations
- Zhejiang Chinese Medical University (CN)
- Corresponding author
- Bao, Jie
- He, Zhixing
- Venue
- Arthritis Research & Therapy
- Published
- 2021-09-14
- Volume
- 23
- Issue
- 1
- Pages
- 240-240
- ISSN
- 1478-6354 (ISSN-L)
- 1478-6362
- PMC
- PMC8439074
- OpenAlex
- W3199979931
- Cited by
- 52
- References
- 40
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 14 · 2023: 17 · 2022: 8 · 2021: 1
- FWCI
- 3.14
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Arthritis Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (82074217, 81973829)
- Natural Science Foundation of Zhejiang Province (LY21H270006)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
- Keywords
- gut microbiota, prednisone, glucocorticoids, systemic lupus erythematosus, MRL/lpr mice, fecal microbiota transplantation, dose-dependent effects, Ruminococcus, Alistipes, Lactobacillus, glucocorticoid adverse effects, treatment efficacy
- MeSH terms
- Gastrointestinal Microbiome, Animals, Disease Models, Animal, Glucocorticoids, Lupus Erythematosus, Systemic, Prednisone, Mice, Inbred MRL lpr, Mice
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