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High dietary zinc supplementation increases the occurrence of tetracycline and sulfonamide resistance genes in the intestine of weaned pigs

Vahjen, Wilfried, Pietruszyńska, Dominika, Starke, Ingo C., Zentek, Jürgen·2015·Gut Pathogens
DOI 10.1186/s13099-015-0071-3PMC PMC4551370
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Fig. 1 Time dependent effect of antibiotic resistance development. Combined data from all intestinal sites; open bar low dietary Zn; bar with diagonal lines intermediate dietary Zn; hatched bar high dietary Zn; a,bSignificantly different; * = trend (p < 0.1) for difference to low and intermediate dietary Zn groups. a tetA gene; b sul1 gene
Fig. 1 Time dependent effect of antibiotic resistance development. Combined data from all intestinal sites; open bar low dietary Zn; bar with diagonal lines intermediate dietary Zn; hatched bar high dietary Zn; a,bSignificantly different; * = trend (p < 0.1) for difference to low and intermediate dietary Zn groups. a tetA gene; b sul1 geneCC BY · PubMed Central
Fig. 2 Distribution of antibiotic resistance in the intestine of pigs. Combined data from all sampling days; open bar low dietary Zn; bar with diagonal lines intermediate dietary Zn; hatched bar high dietary Zn; a,bSignificantly different; a = tetA gene; b sul1 gene
Fig. 2 Distribution of antibiotic resistance in the intestine of pigs. Combined data from all sampling days; open bar low dietary Zn; bar with diagonal lines intermediate dietary Zn; hatched bar high dietary Zn; a,bSignificantly different; a = tetA gene; b sul1 geneCC BY · PubMed Central

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Research works printed but not linked: 23

  1. Pettigrew JE (2006) Reduced use of antibiotic growth promoters in diets fed to weanling pigs; dietary tools, part 1. Anim Biotechnol 17:207–215 · DOI
  2. Starke IC, Pieper R, Neumann K, Zentek J, Vahjen W (2014) The impact of high dietary zinc oxide on the development of the intestinal microbiota in weaned piglets. FEMS Microbiol Ecol 87:416–427 · DOI
  3. Vahjen W, Pieper R, Zentek J (2010) Bar-coded pyrosequencing of 16S rRNA gene amplicons reveals changes in ileal porcine bacterial communities due to high dietary zinc intake. Appl Environ Microbiol 76:6689–6691 · DOI
  4. Broom LJ, Miller HM, Kerr KG, Knapp JS (2006) Effects of zinc oxide and Enterococcus faecium SF68 dietary supplementation on the performance, intestinal microbiota and immune status of weaned piglets. Res Vet Sci 80:45–54 · DOI
  5. Hojberg O, Canibe N, Poulsen HD, Hedemann MS, Jensen BB (2005) Influence of dietary zinc oxide and copper sulfate on the gastrointestinal ecosystem in newly weaned piglets. Appl Environ Microb 71:2267–2277 · DOI
  6. Vahjen W, Pieper R, Zentek J (2011) Increased dietary zinc oxide changes the bacterial core and enterobacterial composition in the ileum of piglets. J Anim Sci 89:2430–2439 · DOI
  7. Bednorz C, Oelgeschläger K, Kinnemann B, Hartmann S, Neumann K, Pieper R, Bethe A, Semmler T, Tedin K, Schierack P, Wieler LH, Guenther S (2013) The broader context of antibiotic resistance: zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo. Int J Med Microbiol 303:396–403 · DOI
  8. Burgos Y, Beutin L (2010) Common origin of plasmid encoded alpha-hemolysin genes in Escherichia coli. BMC Microbiol 10:193 · DOI
  9. Rayamajhi N, Cha SB, Kang ML, Lee SI, Lee HS, Yoo HS (2009) Inter- and intraspecies plasmid-mediated transfer of florfenicol resistance in Enterobacteriaceae isolates from swine. Appl Environ Microbiol 75:5700–5703 · DOI
  10. Liu P, Pieper R, Rieger J, Vahjen W, Davin R, Plendl J, Meyer W, Zentek J (2014) Effect of dietary zinc oxide on morphological characteristics, mucin composition and gene expression in the colon of weaned piglets. PLoS One 9:e91091. doi: 10.1371/journal.pone.0091091 · DOI
  11. Martin L, Pieper R, Schunter N, Vahjen W, Zentek J (2013) Performance, organ zinc concentration, jejunal brush border membrane enzyme activities and mRNA expression in piglets fed with different levels of dietary zinc. Arch Anim Nutr 67:248–261 · DOI
  12. Holzel CS, Muller C, Harms KS, Mikolajewski S, Schafer S, Schwaiger K, Bauer J (2012) Heavy metals in liquid pig manure in light of bacterial antimicrobial resistance. Environ Res 113:21–27 · DOI
  13. Cavaco LM, Hasman H, Aarestrup FM (2011) Zinc resistance of Staphylococcus aureus of animal origin is strongly associated with methicillin resistance. Vet Microbiol 150:344–348 · DOI
  14. Starke IC, Zentek J, Vahjen W (2013) Ex vivo-growth response of porcine small intestinal bacterial communities to pharmacological doses of dietary zinc oxide. PLoS One 8:e56405. doi: 10.1371/journal.pone.0056405 · DOI
  15. Jacela JY, DeRouchey JM, Tokach MD, Goodband RD, Nelssen JL, Renter DG, Dritz SS (2010) Feed additives for swine: fact sheets—high dietary levels of copper and zinc for young pigs, and phytase. J Swine Health Prod 18:87–91 · DOI
  16. Speer BS, Shoemaker NB, Salyers AA (1992) Bacterial resistance to tetracycline: mechanisms, transfer, and clinical significance. Clin Microbiol Rev 5:387–399 · DOI
  17. Sköld O (2001) Resistance to trimethoprim and sulfonamides. Vet Res 32:261–273 · DOI
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Metadata

Authors
Vahjen, W., Pietruszyńska, D., Starke, I. C., & Zentek, J.
Venue
Gut Pathogens
Publisher
Springer Science and Business Media LLC
Published
2015-08-26
Volume
7
Issue
1
ISSN
1757-4749
DOI
10.1186/s13099-015-0071-3
PMC
PMC4551370
Cited by
99
References
0
Language
en
Funders
Deutsche Forschungsgemeinschaft (SFB852/A01)

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