Cited by 33Epigenetics and DNA MethylationBirth, Development, and HealthTelomeres, Telomerase, and Senescence
Evaluation of pediatric epigenetic clocks across multiple tissues
Open accessFang, Fang, Zhou, Linran, Perng, Wei, Marsit, Carmen J., Knight, Anna K., Cardenas, Andres, Aung, Max T., Hivert, Marie-France +91 more·2023·Clinical Epigenetics
Abstract
Background: Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination. Results: Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples. Conclusions: Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
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DNA methylation-based age estimates combine selected cytosine-phosphate-guanine sites using algorithms trained for particular ages and tissues.
“DNA methylation–based age estimates combine selected cytosine–phosphate–guanine sites using algorithms trained for particular ages and tissues [132,133].”
From Placental Pathophysiology and Developmental Programming of Adult Cardiometabolic Risk: A Narrative Review of Pregnancy Exposures (2026) · cites this paper as [132]
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References 25 · Cited by 33
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- Authors
- Fang, F., Zhou, L., Perng, W., Marsit, C. J., Knight, A. K., Cardenas, A., Aung, M. T., Hivert, M.-F., Aris, I. M., Goodrich, J. M., Smith, A. K., Gaylord, A., Fry, R. C., Oken, E., O’Connor, G., Ruden, D. M., Trasande, L., Herbstman, J. B., Camargo, C. A., Bush, N. R., Dunlop, A. L., Dabelea, D. M., Karagas, M. R., Breton, C. V., Ober, C., Everson, T. M., Page, G. P., Ladd-Acosta, C., Outcomes, O. B. O. P. C. F. E. I. O. C. H., Smith, P. B., Newby, L. K., Jacobson, L. P., Catellier, D. J., Gershon, R., Cella, D., Laham, F. R., Mansbach, J. M., Wu, S., Spergel, J. M., Celedón, J. C., Puls, H. T., Teach, S. J., Porter, S. C., Waynik, I. Y., Iyer, S. S., Samuels-Kalow, M. E., D.Thompson, A., Stevenson, M. D., Bauer, C. S., Inhofe, N. R., Boos, M., Macias, C. G., Gern, J., Jackson, D., Bacharier, L., Kattan, M., Wood, R., Rivera-Spoljaric, K., Bacharier, L., Bastain, T., Farzan, S., Habre, R., Karr, C., Tylavsky, F., Mason, A., Zhao, Q., Sathyanarayana, S., Bush, N., LeWinn, K. Z., Lester, B., Carter, B., Pastyrnak, S., Neal, C., Smith, L., Helderman, J., McEvoy, C., Tepper, R., Lyall, K., Volk, H., Schmidt, R., Croen, L., O’Shea, M., Vaidya, R., Obeid, R., Rollins, C., Bear, K., Pastyrnak, S., Lenski, M., Singh, R., Msall, M., Frazier, J., Gogcu, S., Montgomery, A., Kuban, K., Douglass, L., Jara, H., Joseph, R., Kerver, J. M., & Perera, F.
- Affiliations
- RTI International (US)
- Colorado School of Public Health (US)
- Emory University (US)
- University of Southern California (US)
- Harvard University (US)
- University of Michigan (US)
- New York University (US)
- University of North Carolina at Chapel Hill (US)
- Boston University (US)
- Wayne State University (US)
- Columbia University (US)
- Dartmouth College (US)
- University of Chicago (US)
- Johns Hopkins University (US)
- University of California, San Francisco (US)
- Corresponding author
- Fang, Fang
- ORCID
- Perng, Wei
- Marsit, Carmen J.
- Knight, Anna K.
- Aung, Max T.
- Hivert, Marie-France
- Aris, Izzuddin M.
- Goodrich, Jaclyn M.
- Smith, Alicia K.
- Gaylord, Abigail
- Fry, Rebecca C.
- Oken, Emily
- O’Connor, George
- Ruden, Douglas M.
- Trasande, Leonardo
- Herbstman, Julie B.
- Camargo, Carlos A.
- Dunlop, Anne L.
- Dabelea, Dana M.
- Karagas, Margaret R.
- Breton, Carrie V.
- Ober, Carole
- Everson, Todd M.
- Page, Grier P.
- Newby, L. K.
- Jacobson, L. P.
- Catellier, D. J.
- Gershon, R.
- Cella, D.
- Mansbach, J. M.
- Wu, S.
- Spergel, J. M.
- Puls, H. T.
- Teach, S. J.
- Bauer, C. S.
- Macias, C. G.
- Jackson, D.
- Kattan, M.
- Bastain, T.
- Farzan, S.
- Habre, R.
- Karr, C.
- Zhao, Q.
- Sathyanarayana, S.
- LeWinn, K. Z.
- Lester, B.
- McEvoy, C.
- Tepper, R.
- Lyall, K.
- Volk, H.
- Schmidt, R.
- Croen, L.
- Rollins, C.
- Singh, R.
- Msall, M.
- Frazier, J.
- Gogcu, S.
- Kuban, K.
- Douglass, L.
- Jara, H.
- Joseph, R.
- Kerver, J. M.
- Perera, F.
- Venue
- Clinical Epigenetics
- Published
- 2023-09-02
- Volume
- 15
- Issue
- 1
- Pages
- 142-142
- ISSN
- 1868-7075 (ISSN-L)
- 1868-7083
- PMC
- PMC10475199
- OpenAlex
- W4386387132
- Cited by
- 33
- References
- 25
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 4
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Clinical Epigenetics (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Center for Clinical and Translational Research (KL2-TR002534)
- NIH Office of the Director (R01MD009064, UH3OD023286, UH3OD023305, UH3OD023290, UH3OD023253, R01DK076648, UH3OD023275, UH3OD023287)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Keywords
- epigenetic clocks, biological age, DNA methylation, gestational age estimation, chronological age estimation, Horvath clock, buccal epithelial cells, placental tissue, blood cells, tissue comparison
- MeSH terms
- Child, Female, Humans, Infant, Placenta, Pregnancy, DNA Methylation, Epigenesis, Genetic, Epigenomics
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