Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

Verberk, Inge M. W.; Thijssen, Elisabeth; Koelewijn, Jannet; Mauroo, Kimberley; Vanbrabant, Jeroen; de Wilde, Arno; Zwan, Marissa D.; Verfaillie, Sander C. J.; Ossenkoppele, Rik; Barkhof, Frederik; van Berckel, Bart N. M.; Scheltens, Philip; van der Flier, Wiesje M.; Stoops, Erik; Vanderstichele, Hugo M.; Teunissen, Charlotte E.

doi:10.1186/s13195-020-00682-7

Combination of plasma amyloid beta(1-42/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology

Background Blood-based biomarkers for Alzheimer’s disease (AD) might facilitate identification of participants for clinical trials targeting amyloid beta (Abeta) accumulation, and aid in AD diagnostics. We examined the potential of plasma markers Abeta (1-42/1-40) , glial fibrillary acidic protei…