The DOI matches its Crossref record.
Myocarditis as a lupus challenge: two case reports
Open accessAbstract
Background: Myocarditis is an uncommon manifestation of systemic lupus erythematosus in which the clinical presentation can range from subclinical to life-threatening. We report cases of two patients who presented to our hospital with myocarditis as an initial manifestation of systemic lupus erythematosus despite negative results of extensive workup that excluded other diagnoses. The mainstays of treatment are corticosteroids, immunosuppressive agents, and anti-heart failure medications, with use of the latter being case-specific. Mycophenolate mofetil was the cornerstone of the proposed treatment for induction of remission, although it is well known to be used as a maintenance therapy in lupus myocarditis. Case presentation: Both Emirati patients described satisfied the diagnostic criteria for mixed connective tissue disease (systemic lupus predominant) and systemic lupus erythematous. Other differential diagnoses of myocarditis were excluded. The patients were started on pulsed steroid followed by oral steroid, with hydroxychloroquine, mycophenolate mofetil, and anti-heart failure medications used as needed. Dramatic responses were noted in the first few weeks in terms of symptoms. Conclusion: Early recognition and treatment of lupus myocarditis is needed to avoid fatal consequences.
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“between 5% and 14% of patients diagnosed with systemic lupus erythematosus also present with myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [27]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Myocarditis exhibits a notable association with systemic autoimmune diseases.”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [27]
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In the citing paper
“≈ 50% of patients with systemic lupus erythematosus manifest a subclinical form of myocarditis, as confirmed by autopsy studies”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [27]
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Research works printed but not linked: 9
- Thomas G, Cohen Aubart F, Chiche L, Haroche J, Hié M, Hervier B, et al. Lupus myocarditis: initial presentation and longterm outcomes in a multicentric series of 29 patients. J Rheumatol. 2016;44(1):24–32. · DOI
- Shinkawa Y, Yagita M, Fujita M. Myocarditis in mixed connective tissue disease: a case report. J Clin Case Rep. 2016;6:679. · DOI
- Zawadowski G, Klarich K, Moder K, Edwards W, Cooper L. A contemporary case series of lupus myocarditis. Lupus. 2012;21(13):1378–84. · DOI
- Zhang L, Zhu YL, Li MT, Gao N, You X, Wu QJ, et al. Lupus myocarditis: a case–control study from China. Chin Med J (Engl). 2015;128(19):2588–94. · DOI
- Woo S, Hwang G, Kang S, Park J, Park S, Lee Y, et al. Lupus myocarditis presenting as acute congestive heart failure: a case report. J Korean Med Sci. 2009;24(1):176–8. · DOI
- Baquero G, Banchs J, Naccarelli G, Gonzalez M, Wolbrette D. Cardiogenic shock as the initial presentation of systemic lupus erythematosus: a case report and review of the literature. Congest Heart Fail. 2012;18(6):337–41. · DOI
- Appenzeller S, Pineau C, Clarke A. Acute lupus myocarditis: clinical features and outcome. Lupus. 2011;20(9):981–8. · DOI
- Perel-Winkler A, Bokhari S, Perez-Recio T, Zartoshti A, Askanase A, Geraldino-Pardilla L. Myocarditis in systemic lupus erythematosus diagnosed by 18F-fluorodeoxyglucose positron emission tomography. Lupus Sci Med. 2018;5(1):e000265. · DOI
- Gordon C, Amissah-Arthur M, Gayed M, Brown S, Bruce I, D’Cruz D, et al. The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults: executive summary. Rheumatology. 2017;57(1):14–8. · DOI
Cited by
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- Al-Nokhatha, S. A., Khogali, H. I., Al Shehhi, M. A., & Jassim, I. T.
- Affiliations
- Tawam Hospital (AE)
- Venue
- Journal of Medical Case Reports
- Published
- 2019-11-20
- Volume
- 13
- Issue
- 1
- Pages
- 343-343
- ISSN
- 1752-1947 (ISSN-L)
- PMC
- PMC6864968
- OpenAlex
- W2991627402
- Cited by
- 16
- References
- 0
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 2 · 2022: 1 · 2020: 2
- FWCI
- 0.57
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Journal of Medical Case Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Rheumatology › Vasculitis and related conditions
- Keywords
- lupus myocarditis, systemic lupus erythematosus, mixed connective tissue disease, mycophenolate mofetil, hydroxychloroquine, corticosteroid therapy, early diagnosis, treatment response
- MeSH terms
- Adrenal Cortex Hormones, Adult, Female, Humans, Hydroxychloroquine, Immunosuppressive Agents, Lupus Erythematosus, Systemic, Mycophenolic Acid, Myocarditis, Treatment Outcome
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
