The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review
Open accessAbstract
Exosomes are extracellular membranous nanovesicles that mediate local and systemic intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into target cells, thus altering the behaviors of recipient cells. Recent studies have revealed that these vesicles play a critical role in many biological functions, such as cell proliferation, immune regulation, nerve regeneration, and cancer. Adipose-derived stem cells (ADSCs) are now considered a multipotent and abundant tool in the field of cell therapy and regenerative medicine. ADSCs can produce and secrete many exosomes, which inherit multiple functions of cells. Therefore, in this review, we will introduce the characteristics of exosomes derived from ADSCs (ADSC-Exos), describe their functions in different biological processes, summarize the latest research achievements, describe their limitations in cell-free therapy, and provide further insights into their clinical application potential for the treatment of certain diseases.
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A recent study showed that exosome-coating of biomaterials accelerated hBMSC cell adhesion, proliferation, osteogenic differentiation, and also the transport of numerous pro-angiogenic biomolecules, such as VEGF.
“A recent study showed that exosome-coating of biomaterials accelerated hBMSC cell adhesion, proliferation, osteogenic differentiation [59], and also the transport of numerous pro-angiogenic biomolecules, such as the vascular endothelial growth factor (VEGF) [60,61].”
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References 115 · Cited by 269
Research works printed but not linked: 1
- [78]Yang Yujia Cai Yue Zhang Yuan Liu Juan Xu Zhiqiang Exosomes Secreted by Adipose-Derived Stem Cells Contribute to Angiogenesis of Brain Microvascular Endothelial Cells Following Oxygen–Glucose Deprivation In Vitro Through MicroRNA-181b/TRPM7 Axis Journal of Molecular Neuroscience 2018 65 1 74 83 10.1007/s12031-018-1071-9 29705934 · DOI
- Authors
- Hong, P., Yang, H., Wu, Y., Li, K., & Tang, Z.
- Affiliations
- Central South University (CN)
- Corresponding author
- Li, Kun
- Tang, Zhangui
- Venue
- Stem Cell Research & Therapy
- Published
- 2019-08-07
- Volume
- 10
- Issue
- 1
- Pages
- 242-242
- ISSN
- 1757-6512 (ISSN-L)
- PMC
- PMC6686455
- OpenAlex
- W2965010617
- Cited by
- 269
- References
- 115
- Citations by year
- 2026: 22 · 2025: 36 · 2024: 48 · 2023: 43 · 2022: 37 · 2021: 50 · 2020: 30 · 2019: 3
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Stem Cell Research & Therapy (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China ((81800952)
- Natural Science Foundation of Hunan Province (2018JJ3712)
- Fundamental Research Funds for Central Universities of the Central South University (2018zzts838)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- exosomes, adipose-derived stem cells, extracellular vesicles, intercellular communication, cell-free therapy, regenerative medicine, cell therapy, immune regulation, nerve regeneration, cancer, clinical application
- MeSH terms
- Adipose Tissue, Animals, Humans, Nerve Regeneration, Reperfusion Injury, Neovascularization, Physiologic, Regenerative Medicine, Cell Proliferation, Exosomes, Mesenchymal Stem Cells
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