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Cited by 30Congenital heart defects researchSingle-cell and spatial transcriptomicsCardiac Fibrosis and Remodeling

Cell-cell interactions in the heart: advanced cardiac models and omics technologies

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Tan, Shuai, Yang, Jingsi, Hu, Shijun, Lei, Wei·2024·Stem Cell Research & Therapy
DOI 10.1186/s13287-024-03982-zPMC PMC11470663
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Abstract

A healthy heart comprises various cell types, including cardiomyocytes, endothelial cells, fibroblasts, immune cells, and among others, which work together to maintain optimal cardiac function. These cells engage in complex communication networks, known as cell-cell interactions (CCIs), which are essential for homeostasis, cardiac structure, and efficient function. However, in the context of cardiac diseases, the heart undergoes damage, leading to alterations in the cellular composition. Such pathological conditions trigger significant changes in CCIs, causing cell rearrangement and the transition between cell types. Studying these interactions can provide valuable insights into cardiac biology and disease mechanisms, enabling the development of new therapeutic strategies. While the development of cardiac organoids and advanced 3D co-culture technologies has revolutionized in vitro studies of CCIs, recent advancements in single-cell and spatial multi-omics technologies provide researchers with powerful and convenient tools to investigate CCIs at unprecedented resolution. This article provides a concise overview of CCIs observed in both normal and injured heart, with an emphasis on the cutting-edge methods used to study these interactions. It highlights recent advancements such as 3D co-culture systems, single-cell and spatial omics technologies, that have enhanced the understanding of CCIs. Additionally, it summarizes the practical applications of CCI research in advancing cardiovascular therapies, offering potential solutions for treating heart disease by targeting intercellular communication.

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Authors
Tan, S., Yang, J., Hu, S., & Lei, W.
Affiliations
Soochow University (CN)
Corresponding author
  • Hu, Shijun
  • Lei, Wei
ORCID
Venue
Stem Cell Research & Therapy
Publisher
Springer Science and Business Media LLC
Published
2024-10-12
Volume
15
Issue
1
Pages
362-362
ISSN
1757-6512 (ISSN-L)
DOI
10.1186/s13287-024-03982-z
PMC
PMC11470663
OpenAlex
W4403353834
Cited by
30
References
138
Citations by year
2026: 16 · 2025: 13 · 2024: 1
FWCI
1.23
Type
journal article
Language
en
Open access
Licence
Locations
  • Stem Cell Research & Therapy (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (HYZHXM01018, 81970223, 2022YFA1104300, 2021YFA1101900, CXZX202210, 82241202, 82170364)
  • Government of Jiangsu Province
  • Natural Science Foundation of Jiangsu Province (BK20240001, CXZX202210)
  • Priority Academic Program Development of Jiangsu Higher Education Institutions (2017B01012)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords
cell-cell interactions, cardiac organoids, 3D co-culture, single-cell omics, spatial omics, intercellular communication, cardiac injury, cardiac regeneration, cardiomyocytes, endothelial cells, cardiac fibroblasts, immune cells, cardiovascular disease treatment
MeSH terms
Animals, Cell Communication, Heart, Humans, Myocardium, Coculture Techniques, Myocytes, Cardiac, Single-Cell Analysis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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