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Cited by 130Antibiotic Resistance in BacteriaSalmonella and Campylobacter epidemiologyAntibiotic Use and Resistance

The Animal-foods-environment interface of Klebsiella pneumoniae in Germany: an observational study on pathogenicity, resistance development and the current situation

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Wareth, Gamal, Neubauer, Heinrich·2021·Veterinary Research
DOI 10.1186/s13567-020-00875-wPMC PMC7871605
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Abstract

Klebsiella (K.) pneumoniae as a multi-drug resistant (MDR) pathogen is an emerging challenge for clinicians worldwide. Virulence factors are capsular antigens, adherence factors, the O-lipopolysaccharide, and siderophores promoting infectivity. Mechanisms of antimicrobial resistance are inactivation of compounds via enzymes, change of membrane permeability, and alteration of the target site of the antimicrobial compound. In addition to environmental resistance, K. pneumoniae can survive increasing concentrations of disinfectants, if exposed. This review describes the temporal and spatial distribution of K. pneumoniae in the past decades in Germany, with emphases on the development of resistance in the non-human columns of the One-Health concept. In general, K. pneumoniae is a neglected pathogen in veterinary and environmental health, and the risk of human infection concerning animal contact and food consumption is barely investigated. Few reports exist (n = 26) on antibiotic resistance of isolates from non-human origin. Multi-drug resistance and extended-spectrum β-lactamase (MDR-ESBL) strains also resistant to carbapenems and antibiotics of the ß-lactam group harbor blaCTX-M, blaOXA, blaTEM, blaSHV, blaCMY, and PMQR have been found in animals, foods, and the environment. Colistin resistant strains carrying the mcr-1 gene were detected in wastewater. The blaCTX-M-15 and blaOXA-48 genes are the most frequently identified AMR genes in isolates of humans and were also the most predominant ESBL-genes in samples collected from animal hosts. Several aspects of the molecular epidemiology and resistance development of K. pneumoniae in farm animal populations, wildlife, and foods need intensive research. Environmental health has to be integrated into national research plans, as a lack of data is apparent. Increasing awareness of the fact that non-human sources can act as a reservoir for this pathogen has to be raised.

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  • Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors.

    “Klebsiella pneumoniae is naturally present in the respiratory and gastrointestinal tracts of humans and has a lower occurrence in animals, possibly due to diet, competition with other bacteria, or genetic virulence factors [70,71,72].”

    From A Systematic Review on Antimicrobial Resistance in Ghana from a One Health Perspective (2024) · cites this paper as [71]

    The Introduction (page unavailable) says K. pneumoniae has been found in the digestive and respiratory tracts of humans. It does not establish that occurrence is lower in animals or attribute any difference to diet, bacterial competition, or genetic virulence factors. The Discussion (page unavailable) says prevalence in animals has not been significantly investigated. (LLM, conf=0.87)

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Authors
Wareth, G., & Neubauer, H.
Affiliations
Friedrich-Loeffler-Institut (DE)
Corresponding author
Wareth, Gamal
ORCID
Venue
Veterinary Research
Publisher
Springer Science and Business Media LLC
Published
2021-02-08
Volume
52
Issue
1
Pages
16-16
ISSN
  • 0928-4249 (ISSN-L)
  • 1297-9716
DOI
10.1186/s13567-020-00875-w
PMC
PMC7871605
OpenAlex
W3129155305
Cited by
130
References
1
Citations by year
2026: 26 · 2025: 35 · 2024: 28 · 2023: 17 · 2022: 21 · 2021: 2 · 2020: 1
FWCI
1.25
Type
journal article
Language
en
Open access
Licence
Locations
  • Veterinary Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Informationszentrum Lebenswissenschaften (ZB MED) (submittedVersion, cc-by)
Funders
Projekt DEAL
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antibiotic Use and Resistance
Keywords
Klebsiella pneumoniae, antimicrobial resistance, extended-spectrum beta-lactamase, carbapenem resistance, colistin resistance, mcr-1, virulence factors, environmental reservoirs, foodborne transmission, One Health, wastewater, wildlife, livestock, molecular epidemiology, Germany
MeSH terms
Anti-Infective Agents, Germany, Klebsiella Infections, Klebsiella pneumoniae, Virulence, Drug Resistance, Multiple, Bacterial

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