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Cited by 437

The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.

Methanogens: biochemical background and biotechnological applications

Open access
Enzmann, Franziska, Mayer, Florian, Rother, Michael, Holtmann, Dirk·2018·AMB Express
DOI 10.1186/s13568-017-0531-x
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Abstract

Since fossil sources for fuel and platform chemicals will become limited in the near future, it is important to develop new concepts for energy supply and production of basic reagents for chemical industry. One alternative to crude oil and fossil natural gas could be the biological conversion of CO 2 or small organic molecules to methane via methanogenic archaea. This process has been known from biogas plants, but recently, new insights into the methanogenic metabolism, technical optimizations and new technology combinations were gained, which would allow moving beyond the mere conversion of biomass. In biogas plants, steps have been undertaken to increase yield and purity of the biogas, such as addition of hydrogen or metal granulate. Furthermore, the integration of electrodes led to the development of microbial electrosynthesis (MES). The idea behind this technique is to use CO 2 and electrical power to generate methane via the microbial metabolism. This review summarizes the biochemical and metabolic background of methanogenesis as well as the latest technical applications of methanogens. As a result, it shall give a sufficient overview over the topic to both, biologists and engineers handling biological or bioelectrochemical methanogenesis.

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Show all 178 references

Research works printed but not linked: 38

  1. Asakawa S, Akagawa-Matsushita M, Morii H, Koga Y, Hayano K (1995) Characterization of Methanosarcina mazeii TMA isolated from a paddy field soil. Curr Microbiol 31:34–38 · doi:10.1007/bf00294631
  2. Bao Y, Huang H, He D, Ju Y, Qi Y (2016) Microbial enhancing coal-bed methane generation potential, constraints and mechanism - a mini-review. J Nat Gas Sci Eng 35:68–78 · doi:10.1016/j.jngse.2016.08.035
  3. Bär K, Mörs F, Götz M, Graf F (2015) Vergleich der biologischen und katalytischen Methanisierung für den Einsatz bei PtG-Konzepten. gwf-Gas 7:1–8
  4. Dykstra CM, Pavlostathis SG (2017) Evaluation of gas and carbon transport in a methanogenic bioelectrochemical system (BES). Biotechnol Bioeng 114:961–969 · doi:10.1002/bit.26230
  5. Feng Y, Zhang Y, Chen S, Quan X (2015) Enhanced production of methane from waste activated sludge by the combination of high-solid anaerobic digestion and microbial electrolysis cell with iron–graphite electrode. Chem Eng J 259:787–794 · doi:10.1016/j.cej.2014.08.048
  6. Guo Z, Thangavel S, Wang L, He Z, Cai W, Wang A, Liu W (2017) Efficient methane production from beer wastewater in a membraneless microbial electrolysis cell with a stacked cathode: the effect of the cathode/anode ratio on bioenergy recovery. Energy Fuels 31:615–620 · doi:10.1021/acs.energyfuels.6b02375
  7. Hara M, Onaka Y, Kobayashi H, Fu Q, Kawaguchi H, Vilcaez J, Sato K (2013) Mechanism of electromethanogenic reduction of CO2 by a thermophilic methanogen. Energy Procedia 37:7021–7028 · doi:10.1016/j.egypro.2013.06.637
  8. Harris JE, Pinn PA (1985) Bacitracin-resistant mutants of a mesophilic Methanobacterium species. Arch Microbiol 143:151–153 · doi:10.1007/bf00411039
  9. Holtmann D, Hannappel A, Schrader J (2014) Microbial electrosynthesis. Encyclopedia of applied electrochemistry. Springer, New York, pp 1268–1275 · doi:10.1007/978-1-4419-6996-5_526
  10. Jiang Y, Su M, Li D (2014) Removal of sulfide and production of methane from carbon dioxide in microbial fuel cells–microbial electrolysis cell (MFCs–MEC) coupled system. Appl Biochem Biotechnol 172:2720–2731 · doi:10.1007/s12010-013-0718-9
  11. Kamagata Y, Kawasaki H, Oyaizu H, Nakamura K, Mikami E, Endo G, Koga Y, Yamasato K (1992) Characterization of three thermophilic strains of Methanothrix (“Methanosaeta”) thermophila sp. nov. and rejection of Methanothrix (“Methanosaeta”) thermoacetophila. Int J Syst Bacteriol 42:463–468 · doi:10.1099/00207713-42-3-463
  12. Kaparaju P, Ellegaard L, Angelidaki I (2009) Optimisation of biogas production from manure through serial digestion: lab-scale and pilot-scale studies. Bioresour Technol 100:701–709 · doi:10.1016/j.biortech.2008.07.023
  13. Kern T, Linge M, Rother M (2015) Methanobacterium aggregans sp. nov., a hydrogenotrophic methanogenic archaeon isolated from an anaerobic digester. Int J Syst Evol Microbiol 65:1975–1980 · doi:10.1099/ijs.0.000210
  14. Kern T, Fischer Martin A, Deppenmeier U, Schmitz RA, Rother M (2016a) Methanosarcina flavescens sp. nov., a methanogenic archaeon isolated from a full-scale anaerobic digester. Int J Syst Evol Microbiol 66:1533–1538 · doi:10.1099/ijsem.0.000894
  15. Kobayashi H, Saito N, Fu Q, Kawaguchi H, Vilcaez J, Wakayama T, Maeda H, Sato K (2013) Bio-electrochemical property and phylogenetic diversity of microbial communities associated with bioelectrodes of an electromethanogenic reactor. J Biosci Bioeng 116:114–117 · doi:10.1016/j.jbiosc.2013.01.001
  16. Koo T, Shin SG, Lee J, Han G, Kim W, Cho K, Hwang S (2017) Identifying methanogen community structures and their correlations with performance parameters in four full-scale anaerobic sludge digesters. Bioresour Technol 228:368–373 · doi:10.1016/j.biortech.2016.12.118
  17. Krieg T, Sydow A, Schröder U, Schrader J, Holtmann D (2014) Reactor concepts for bioelectrochemical syntheses and energy conversion. Trends Biotechnol 32:645–655 · doi:10.1016/j.tibtech.2014.10.004
  18. Liu D, Zhang L, Chen S, Buisman C, ter Heijne A (2016) Bioelectrochemical enhancement of methane production in low temperature anaerobic digestion at 10 °C. Water Res 99:281–287 · doi:10.1016/j.watres.2016.04.020
  19. Mah RA (1980) Isolation and characterization of Methanococcus mazei. Curr Microbiol 3:321–325 · doi:10.1007/bf02601895
  20. Mochimaru H, Tamaki H, Hanada S, Imachi H, Nakamura K, Sakata S, Kamagata Y (2009) Methanolobus profundi sp. nov., a methylotrophic methanogen isolated from deep subsurface sediments in a natural gas field. Int J Syst Evol Microbiol 59:714–718 · doi:10.1099/ijs.0.001677-0
  21. Mondorf S, Deppenmeier U, Welte C (2012) A novel inducible protein production system and neomycin resistance as selection marker for Methanosarcina mazei. Archaea 2012:1–8
  22. Mūller B, Allmansberger R, Klein A (1985) Termination of a transcription unit comprising highly expressed genes in the archaebacterium Methanococcus voltae. Nucleic Acids Research 13(18):6439–6445 · doi:10.1093/nar/13.18.6439
  23. Park SY, Liang Y (2016) Biogenic methane production from coal: a review on recent research and development on microbially enhanced coalbed methane (MECBM). Fuel 166:258–267 · doi:10.1016/j.fuel.2015.10.121
  24. Porat I, Whitman WB (2009) Tryptophan auxotrophs were obtained by random transposon insertions in the Methanococcus maripaludis tryptophan operon. FEMS Microbiol Lett 297:250–254 · doi:10.1111/j.1574-6968.2009.01689.x
  25. Ravichandran M, Munisamy P, Varadharaju C, Natarajan S (2015) Methanogenic archaea: a multipotent biological candidate focusing toward realizing future global energy. Int J Curr Microbiol Appl Sci 4:785–793
  26. Robichaux M, Howell M, Boopathy R (2003) Methanogenic activity in human periodontal pocket. Curr Microbiol 46:53–58 · doi:10.1007/s00284-002-3807-5
  27. Roeßler M, Pflüger K, Flach H, Lienard T, Gottschalk G, Müller V (2002) Identification of a salt-induced primary transporter for glycine betaine in the methanogen Methanosarcina mazei Gö1. Appl Environ Microbiol 68:2133–2139 · doi:10.1128/aem.68.5.2133-2139.2002
  28. Rother M, Boccazzi P, Bose A, Pritchett MA, Metcalf WW (2005) Methanol-dependent gene expression demonstrates that methyl-coenzyme M reductase is essential in Methanosarcina acetivorans C2A and allows isolation of mutants with defects in regulation of the methanol utilization pathway. J Bacteriol 187:5552–5559 · doi:10.1128/jb.187.16.5552-5559.2005
  29. Saum R, Mingote A, Santos H, Müller V (2009) A novel limb in the osmoregulatory network of Methanosarcina mazei Gö1: N(epsilon)-acetyl-beta-lysine can be substituted by glutamate and alanine. Environ Microbiol 11:1056–1065 · doi:10.1111/j.1462-2920.2008.01826.x
  30. Schink B, Ward JC, Zeikus JG (1981) Microbiology of wetwood: importance of pectin degradation and clostridium species in living trees. Appl Environ Microbiol 42:526–532 · doi:10.1128/aem.42.3.526-532.1981
  31. Soo VWC, McAnulty MJ, Tripathi A, Zhu F, Zhang L, Hatzakis E, Smith PB, Agrawal S, Nazem-Bokaee H, Gopalakrishnan S, Salis HM, Ferry JG, Maranas CD, Patterson AD, Wood TK (2016) Reversing methanogenesis to capture methane for liquid biofuel precursors. Microb Cell Fact 15:11 · doi:10.1186/s12934-015-0397-z
  32. Sorokin DY, Abbas B, Merkel AY, Rijpstra WIC, Damste JSS, Sukhacheva MV, van Loosdrecht MCM (2015) Methanosalsum natronophilum sp. nov., and Methanocalculus alkaliphilus sp. nov., haloalkaliphilic methanogens from hypersaline soda lakes. Int J Syst Evol Microbiol 65:3739–3745 · doi:10.1099/ijsem.0.000488
  33. Tumbula DL, Bowen TL, Whitman WB (1997) Characterization of pURB500 from the archaeon Methanococcus maripaludis and construction of a shuttle vector. J Bacteriol 179:2976–2986 · doi:10.1128/jb.179.9.2976-2986.1997
  34. Voegeli Y, Lohri C, Kassenga G, Baier U, Zurbrügg C (2009) Technical and biological performance of the Arti compact biogas plant for kitchen waste - case study from Tanzania. In: Proceedings Sardinia, 2009, twelfth international waste management and landfill symposium. CISA Publisher, Italy, S. Margherita die Pula, Cagliari
  35. Voordouw G (2011) Production-related petroleum microbiology: progress and prospects. Curr Opin Biotechnol 22:401–405 · doi:10.1016/j.copbio.2010.12.005
  36. Wonglertarak W, Wichitsathian B (2014) Alkaline pretreatment of waste activated sludge in anaerobic digestion. J Clean Energy Technol 2:118–121 · doi:10.7763/jocet.2014.v2.104
  37. Worrell VE, Nagle DP, McCarthy D, Eisenbraun A (1988) Genetic transformation system in the archaebacterium Methanobacterium thermoautotrophicum Marburg. J Bacteriol 170:653–656 · doi:10.1128/jb.170.2.653-656.1988
  38. Zhang JK, Pritchett MA, Lampe DJ, Robertson HM, Metcalf WW (2000) In vivo transposon mutagenesis of the methanogenic archaeon Methanosarcina acetivorans C2A using a modified version of the insect mariner-family transposable element Himar1. Proc Natl Acad Sci USA 97:9665–9670 · doi:10.1073/pnas.160272597

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Metadata

Authors
Enzmann, F., Mayer, F., Rother, M., & Holtmann, D.
Venue
AMB Express
Publisher
Springer Science and Business Media LLC
Published
2018-01-04
Volume
8
Issue
1
Pages
1-1
ISSN
2191-0855 (ISSN-L)
DOI
10.1186/s13568-017-0531-x
OpenAlex
W2781678624
Cited by
437
References
178
FWCI
36.19
Type
journal article
Language
en
Open access
gold
Licence
creativecommons.org/licenses/by/4.0 (tdm)
Funders
BMBF (FKZ 031A226, 033RC013A)

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Enzmann, F., Mayer, F., Rother, M., & Holtmann, D. (2018). Methanogens: biochemical background and biotechnological applications. AMB Express. https://doi.org/10.1186/s13568-017-0531-x

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