H3K36me3, message from chromatin to DNA damage repair
Open accessAbstract
Histone marks control many cellular processes including DNA damage repair. This review will focus primarily on the active histone mark H3K36me3 in the regulation of DNA damage repair and the maintenance of genomic stability after DNA damage. There are diverse clues showing H3K36me3 participates in DNA damage response by directly recruiting DNA repair machinery to set the chromatin at a "ready" status, leading to a quick response upon damage. Reduced H3K36me3 is associated with low DNA repair efficiency. This review will also place a main emphasis on the H3K36me3-mediated DNA damage repair in the tumorigenesis of the newly found oncohistone mutant tumors. Gaining an understanding of different aspects of H3K36me3 in DNA damage repair, especially in cancers, would share the knowledge of chromatin and DNA repair to serve to the drug discovery and patient care.
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Nucleosomes regulate DNA repair mechanisms.
“As it is known that nucleosomes regulate DNA repair mechanisms [71,72]”
From DNA Data Storage. (2023) · cites this paper as [72]
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References 102 · Cited by 109
- Authors
- Sun, Z., Zhang, Y., Jia, J., Fang, Y., Tang, Y., Wu, H., & Fang, D.
- Affiliations
- Zhejiang University (CN)
- Venue
- Cell & Bioscience
- Published
- 2020-01-31
- Volume
- 10
- Issue
- 1
- Pages
- 9-9
- ISSN
- 2045-3701 (ISSN-L)
- PMC
- PMC6995143
- OpenAlex
- W3008360793
- Cited by
- 109
- References
- 102
- Citations by year
- 2026: 14 · 2025: 16 · 2024: 18 · 2023: 20 · 2022: 24 · 2021: 13 · 2020: 4
- FWCI
- 1.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Cell & Bioscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81874153)
- Fundamental Research Funds for the Central Universities (2019QN005)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- H3K36me3, histone modifications, DNA repair, DNA damage response, genome stability, chromatin regulation, carcinogenesis, cancer
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