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Cited by 54Chromatin Remodeling and CancerGenomics and Chromatin DynamicsGenetics and Neurodevelopmental Disorders

Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration

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Jiang, Dongfang, Li, Tingting, Guo, Caixia, Tang, Tie-Shan, Liu, Hongmei·2023·Cell & Bioscience
DOI 10.1186/s13578-023-00953-4PMC PMC9841685
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Abstract

The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-catalyzed covalent modifications to chromatin components and by noncovalent ATP-dependent modifications via chromatin remodeling complexes, including switch/sucrose nonfermentable (SWI/SNF), inositol-requiring 80 (INO80), imitation switch (ISWI) and chromodomain-helicase DNA-binding protein (CHD) complexes. Recent studies have shown that chromatin remodeling is essential in different stages of postnatal and adult neurogenesis. Chromatin deregulation, which leads to defects in epigenetic gene regulation and further pathological gene expression programs, often causes a wide range of pathologies. This review first gives an overview of the regulatory mechanisms of chromatin remodeling. We then focus mainly on discussing the physiological functions of chromatin remodeling, particularly histone and DNA modifications and the four classes of ATP-dependent chromatin-remodeling enzymes, in the central and peripheral nervous systems under healthy and pathological conditions, that is, in neurodegenerative disorders. Finally, we provide an update on the development of potent and selective small molecule modulators targeting various chromatin-modifying proteins commonly associated with neurodegenerative diseases and their potential clinical applications.

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  • Disruption of genes encoding histone modifiers, chromatin remodelers, or associated complexes leads to perturbations extending beyond individual targets, resulting in widespread disorganization of transcriptional programs essential for neurogenesis, regional patterning, and synaptic differentiation.

    “Disruption of genes encoding histone modifiers, chromatin remodelers, or associated complexes leads to perturbations that extend beyond individual targets, resulting in widespread disorganization of transcriptional programs essential for neurogenesis, regional patterning, and synaptic differentiation”

    From Biological hierarchy from genotype to phenotype in syndromic and non-syndromic autism spectrum disorder (2026) · cites this paper as Jiang et al., 2023

    The CNS neurodevelopment section (page unavailable) says chromatin modification produces genome-wide changes tied to gene-expression patterns during neurogenesis. It also reports that loss of BAF155 and BAF170 impairs epigenetic and gene-expression programs in cortical and forebrain development. These passages support broad effects beyond individual targets, but do not establish the claim’s specific extension to transcriptional programs for regional patterning and synaptic differentiation. (LLM, conf=0.82)

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Authors
Jiang, D., Li, T., Guo, C., Tang, T.-S., & Liu, H.
Affiliations
Chinese Academy of Sciences (CN)
Corresponding author
  • Tang, Tie-Shan
  • Liu, Hongmei
ORCID
Venue
Cell & Bioscience
Publisher
Springer Science and Business Media LLC
Published
2023-01-16
Volume
13
Issue
1
Pages
10-10
ISSN
2045-3701 (ISSN-L)
DOI
10.1186/s13578-023-00953-4
PMC
PMC9841685
OpenAlex
W4316662983
Cited by
54
References
319
Citations by year
2026: 9 · 2025: 21 · 2024: 16 · 2023: 8
FWCI
1.43
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell & Bioscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Key Research and Development Program of China (2018YFA0108500)
  • Chinese Academy of Sciences Strategic Priority Research Program (XDA16010107)
  • the National Natural Science Foundation of China (81921006, 81630078, 82030033, 32070780)
  • the State Key Laboratory of Membrane Biology
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
chromatin remodeling, small molecule modulators, brain development, neurodegeneration, SWI/SNF complex, INO80 complex, histone modifications, DNA modification, epigenetic regulation, chromatin-modifying enzymes, neurogenesis, neurodegenerative diseases, drug development

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