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Cited by 10Zebrafish Biomedical Research ApplicationsHematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Zebrafish: a convenient tool for myelopoiesis research

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Hu, Yang-Xi, Jing, Qing·2023·Cell Regeneration
DOI 10.1186/s13619-022-00139-2PMC PMC9810781
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Abstract

Myelopoiesis is the process in which the mature myeloid cells, including monocytes/macrophages and granulocytes, are developed. Irregular myelopoiesis may cause and deteriorate a variety of hematopoietic malignancies such as leukemia. Myeloid cells and their precursors are difficult to capture in circulation, let alone observe them in real time. For decades, researchers had to face these difficulties, particularly in in-vivo studies. As a unique animal model, zebrafish possesses numerous advantages like body transparency and convenient genetic manipulation, which is very suitable in myelopoiesis research. Here we review current knowledge on the origin and regulation of myeloid development and how zebrafish models were applied in these studies.

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Cited by

Sorted by citations

Authors
Hu, Y.-X., & Jing, Q.
Affiliations
  • Shanghai Changzheng Hospital (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
Jing, Qing
ORCID
Venue
Cell Regeneration
Publisher
Springer Science and Business Media LLC
Published
2023-01-03
Volume
12
Issue
1
Pages
2-2
ISSN
2045-9769 (ISSN-L)
DOI
10.1186/s13619-022-00139-2
PMC
PMC9810781
OpenAlex
W4313488539
Cited by
10
References
3
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 3
FWCI
0.32
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell Regeneration (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (92168206)
  • National Key Research and Development Program of China (2019YFA0802700)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Keywords
myelopoiesis, zebrafish, myeloid development, monocytes, macrophages, granulocytes, hematologic malignancies, leukemia, in vivo imaging, genetic engineering

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