Roles of the intestinal microbiota and microbial metabolites in acute GVHD
Open accessAbstract
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is one of the most curative strategies for the treatment of many hematologic malignancies and diseases. However, acute graft-versus-host disease (GVHD) limits the success of allo-HSCT. The prevention and treatment of acute GVHD is the key issue for improving the efficacy of allo-HSCT and has become a research hotspot. The intestine is the primary organ targeted by acute GVHD, and the intestinal microbiota is critical for maintaining the homeostasis of the intestinal microenvironment and the immune response. Many studies have demonstrated the close association between the intestinal microbiota and the pathogenesis of acute GVHD. Furthermore, dysbiosis of the microbiota, which manifests as alterations in the diversity and composition of the intestinal microbiota, and alterations of microbial metabolites are pronounced in acute GVHD and associated with poor patient prognosis. The microbiota interacts with the host directly via microbial surface antigens or microbiota-derived metabolites to regulate intestinal homeostasis and the immune response. Therefore, intervention strategies targeting the intestinal microbiota, including antibiotics, prebiotics, probiotics, postbiotics and fecal microbiota transplantation (FMT), are potential new treatment options for acute GVHD. In this review, we discuss the alterations and roles of the intestinal microbiota and its metabolites in acute GVHD, as well as interventions targeting microbiota for the prevention and treatment of acute GVHD.
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The influence of gut microbiota on host immunity is multifaceted, simultaneously regulating the gut mucosal immune system and the systemic immune system.
“The influence of gut microbiota on host immunity is multifaceted, simultaneously regulating the gut mucosal immune system and systemic immune system (Fig. 2d) [307–310].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [310]
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References 165 · Cited by 71
- Authors
- Lin, D., Hu, B., Li, P., Zhao, Y., Xu, Y., & Wu, D.
- Affiliations
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Corresponding author
- Xu, Yang
- Wu, Depei
- Venue
- Experimental Hematology & Oncology
- Published
- 2021-10-27
- Volume
- 10
- Issue
- 1
- Pages
- 49-49
- ISSN
- 2162-3619 (ISSN-L)
- PMC
- PMC8555140
- OpenAlex
- W3208309566
- Cited by
- 71
- References
- 165
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 15 · 2023: 16 · 2022: 14
- FWCI
- 1.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Experimental Hematology and Oncology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- social development project of jiangsu province (BE2019655)
- jiangsu province key r&d program (BE2019798)
- national key research and development program (2019YFC0840604)
- national natural science foundation of china (82020108003, 82070187)
- priority academic program development of jiangsu higher education institutions
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- acute graft-versus-host disease, gut microbiota, microbial metabolites, allogeneic hematopoietic stem cell transplantation, dysbiosis, intestinal homeostasis, microbiota-immune interactions, probiotics, prebiotics, postbiotics, fecal microbiota transplantation, antibiotics
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