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Cited by 288Osteoarthritis Treatment and MechanismsProteoglycans and glycosaminoglycans researchPharmacological Effects of Medicinal Plants

Recent advances in hyaluronic acid based therapy for osteoarthritis

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Bowman, Steven, Awad, Mohamed E., Hamrick, Mark W., Hunter, Monte, Fulzele, Sadanand·2018·Clinical and Translational Medicine
DOI 10.1186/s40169-017-0180-3PMC PMC5814393
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Abstract

Osteoarthritis is a debilitating disease that has increased in prevalence across the world due to the aging population. Currently, physicians use a plethora of treatment strategies to try and slow down the progression of the disease, but none have been shown to ubiquitously treat and cure the disease. One of the strategies uses the high molecular weight molecule hyaluronic acid as either an injectable or oral supplement for treatment. Hyaluronic acid (HA) is a relatively new treatment that has shown varied results through several clinical trials. It can be used as a scaffold for engineering new treatments and several new preparations have just been added to the market. A comprehensive search was conducted through several search databases according our inclusion and exclusion criteria. This review included 44 prospective clinical trial investigating the feasibility and efficacy of HA injection for knee, hip, and ankle osteoarthritis. This review will take a closer look at hyaluronic acid and its properties, as well clinical effectiveness and future options.

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  • PN has shown favorable outcomes in improving knee function and alleviating pain without causing serious adverse effects.

    “In addition, PN has shown favorable outcomes in improving knee function and alleviating pain without causing serious adverse effects [42,43,44,45,46,47].”

    From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [45]

    The Introduction and Human clinical studies involving hyaluronic acid sections discuss pain relief, function, and adverse reactions for hyaluronic acid injections, not PN. A search for “polynucleotide” found no passage addressing PN’s effects on knee function, pain, or serious adverse effects. (LLM, conf=0.76)

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Authors
Bowman, S., Awad, M. E., Hamrick, M. W., Hunter, M., & Fulzele, S.
Affiliations
Augusta University (US)
Corresponding author
Fulzele, Sadanand
ORCID
Venue
Clinical and Translational Medicine
Publisher
Wiley
Published
2018-02-16
Volume
7
Issue
1
Pages
6-6
ISSN
2001-1326 (ISSN-L)
DOI
10.1186/s40169-017-0180-3
PMC
PMC5814393
OpenAlex
W2794995305
Cited by
288
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0
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en
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  • Clinical and Translational Medicine (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
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Topics
  • Health Sciences › Medicine › Rheumatology › Osteoarthritis Treatment and Mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Proteoglycans and glycosaminoglycans research
  • Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
Keywords
hyaluronic acid, osteoarthritis, intra-articular injection, knee osteoarthritis, hip osteoarthritis, ankle osteoarthritis, clinical efficacy, cartilage regeneration, biomaterial scaffolds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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