Cancer-associated adipocytes as immunomodulators in cancer
Open accessAbstract
Cancer-associated adipocytes (CAAs), as a main component of the tumor-adipose microenvironment (TAME), have various functions, including remodeling the extracellular matrix and interacting with tumor cells or infiltrated leukocytes through a variety of mutual signals. Here, we summarize the primary interplay among CAAs, the immune response and cancer with a focus on the mechanistic aspects of these relationships. Finally, unifying our understanding of CAAs with the immune cell function may be an effective method to enhance the efficacy of immunotherapeutic and conventional treatments.
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Other immune checkpoints, abnormal angiogenesis, immunosuppressive immune cells or cytokines, cancer-associated adipocytes, and hyperactive cancer-associated fibroblasts also modulate the cancer-immune set point and promote immune tolerance.
“Apart from PD-1 signaling, other immune checkpoints, abnormal angiogenesis, immunosuppressive immune cells or cytokines, cancer-associated adipocytes, and hyperactive cancer-associated fibroblasts also modulate cancer-immune set point and promote immune tolerance [15–20].”
From Combination strategies with PD-1/PD-L1 blockade: current advances and future directions (2022) · cites this paper as [20]
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References 215 · Cited by 105
Research works printed but not linked: 1
- [74]Keppel MP Saucier N Mah AY Vogel TP Cooper MA Activation-specific metabolic requirements for NK cell IFN-γ production J Immunol 2015 194 4 1954 1962 10.4049/jimmunol.1402099 25595780 PMC4323953 · DOI
- Authors
- Wu, Q., Li, B., Li, J., Sun, S., Yuan, J., & Sun, S.
- Affiliations
- Renmin Hospital of Wuhan University (CN)
- Corresponding author
- Sun, Si
- Yuan, Jingping
- Venue
- Biomarker Research
- Published
- 2021-01-07
- Volume
- 9
- Issue
- 1
- Pages
- 2-2
- ISSN
- 2050-7771 (ISSN-L)
- PMC
- PMC7792018
- OpenAlex
- W3118453747
- Cited by
- 105
- References
- 215
- Citations by year
- 2026: 9 · 2025: 21 · 2024: 22 · 2023: 28 · 2022: 22 · 2021: 3
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Biomarker Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81471781, 81903166)
- Natural Science Foundation of Hubei Province (2018CKB916)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- cancer-associated adipocytes, immunomodulation, extracellular matrix remodeling, tumor-infiltrating leukocytes, tumor-immune cell interactions, cancer immunotherapy, tumor microenvironment
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