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Cited by 63S100 Proteins and AnnexinsCalpain Protease Function and RegulationBone and Dental Protein Studies

S100A6: molecular function and biomarker role

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Wang, Yidian, Kang, Xuewen, Kang, Xin, Yang, Fengguang·2023·Biomarker Research
DOI 10.1186/s40364-023-00515-3PMC PMC10481514
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Abstract

S100A6 (also called calcyclin) is a Ca 2+ -binding protein that belongs to the S100 protein family. S100A6 has many functions related to the cytoskeleton, cell stress, proliferation, and differentiation. S100A6 also has many interacting proteins that are distributed in the cytoplasm, nucleus, cell membrane, and outside the cell. Almost all these proteins interact with S100A6 in a Ca 2+ -dependent manner, and some also have specific motifs responsible for binding to S100A6. The expression of S100A6 is regulated by several transcription factors (such as c-Myc, P53, NF-κB, USF, Nrf2, etc.). The expression level depends on the specific cell type and the transcription factors activated in specific physical and chemical environments, and is also related to histone acetylation, DNA methylation, and other epigenetic modifications. The differential expression of S100A6 in various diseases, and at different stages of those diseases, makes it a good biomarker for differential diagnosis and prognosis evaluation, as well as a potential therapeutic target. In this review, we mainly focus on the S100A6 ligand and its transcriptional regulation, molecular function (cytoskeleton, cell stress, cell differentiation), and role as a biomarker in human disease and stem cells.

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  • DAA pathway phenotypes are associated with AD.

    “APOE4 derived iAstrocytes showed increased inflammatory protein expression including those associated with DAA pathway phenotypes in AD [42][43][44][45] .”

    From APOE4-drives brain bioenergetic shifts independent of Alzheimer’s disease pathology (2026) · cites this paper as [44]

    The 'Biomarker role of S100A6 in other diseases' section discusses reactive astrocytes in an ALS mouse model, not DAA phenotypes in Alzheimer’s disease. Searches for 'DAA,' 'Alzheimer,' and APOE4-related astrocyte inflammation found no passage in our copy addressing the attributed association. (LLM, conf=0.75)

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Authors
Wang, Y., Kang, X., Kang, X., & Yang, F.
Affiliations
Xi'an Honghui Hospital (CN)
Corresponding author
Kang, Xuewen
ORCID
Venue
Biomarker Research
Publisher
Springer Science and Business Media LLC
Published
2023-09-05
Volume
11
Issue
1
Pages
78-78
ISSN
2050-7771 (ISSN-L)
DOI
10.1186/s40364-023-00515-3
PMC
PMC10481514
OpenAlex
W4386457377
Cited by
63
References
4
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2026: 24 · 2025: 23 · 2024: 16
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1.73
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journal article
Language
en
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  • Biomarker Research (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (82272536)
  • Gansu Youth Science and Technology Fund Program, China (21JR11RA198)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
  • Health Sciences › Medicine › Rheumatology › Bone and Dental Protein Studies
Keywords
S100A6, calcyclin, S-100 protein, calcium-binding proteins, protein-protein interaction, transcriptional regulation, epigenetic regulation, biomarkers, cytoskeleton, cellular stress, cell differentiation, stem cells, disease diagnosis and prognosis, therapeutic target

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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