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The DOI matches its Crossref record; 132 of the 132 references it cites were found in a registry or an index.

The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC)

Open access
Cohen, Ezra E. W., Bell, R. Bryan, Bifulco, Carlo B., Burtness, Barbara, Gillison, Maura L., Harrington, Kevin J., Le, Quynh-Thu, Lee, Nancy Y., Leidner, Rom, Lewis, Rebecca L., Licitra, Lisa, Mehanna, Hisham, Mell, Loren K., Raben, Adam, Sikora, Andrew G., Uppaluri, Ravindra, Whitworth, Fernanda, Zandberg, Dan P., Ferris, Robert L.·2019·Journal for ImmunoTherapy of Cancer
DOI 10.1186/s40425-019-0662-5
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Abstract

Head and neck cancers, including those of the lip and oral cavity, nasal cavity, paranasal sinuses, oropharynx, larynx and nasopharynx represent nearly 700,000 new cases and 380,000 deaths worldwide per annum, and account for over 10,000 annual deaths in the United States alone. Improvement in outcomes are needed for patients with recurrent and or metastatic squamous cell carcinoma of the head and neck (HNSCC). In 2016, the US Food and Drug Administration (FDA) granted the first immunotherapeutic approvals - the anti-PD-1 immune checkpoint inhibitors nivolumab and pembrolizumab - for the treatment of patients with recurrent squamous cell carcinoma of the head and neck (HNSCC) that is refractory to platinum-based regimens. The European Commission followed in 2017 with approval of nivolumab for treatment of the same patient population, and shortly thereafter with approval of pembrolizumab monotherapy for the treatment of recurrent or metastatic HNSCC in adults whose tumors express PD-L1 with a ≥ 50% tumor proportion score and have progressed on or after platinum-containing chemotherapy. Then in 2019, the FDA granted approval for PD-1 inhibition as first-line treatment for patients with metastatic or unresectable, recurrent HNSCC, approving pembrolizumab in combination with platinum and fluorouracil for all patients with HNSCC and pembrolizumab as a single agent for patients with HNSCC whose tumors express a PD-L1 combined positive score ≥ 1. These approvals marked the first new therapies for these patients since 2006, as well as the first immunotherapeutic approvals in this disease. In light of the introduction of these novel therapies for the treatment of patients with head and neck cancer, The Society for Immunotherapy of Cancer (SITC) formed an expert committee tasked with generating consensus recommendations for emerging immunotherapies, including appropriate patient selection, therapy sequence, response monitoring, adverse event management, and biomarker testing. These consensus guidelines serve as a foundation to assist clinicians' understanding of the role of immunotherapies in this disease setting, and to standardize utilization across the field for patient benefit. Due to country-specific variances in approvals, availability and regulations regarding the discussed agents, this panel focused solely on FDA-approved drugs for the treatment of patients in the U.S.

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Metadata

Authors
Cohen, E. E. W., Bell, R. B., Bifulco, C. B., Burtness, B., Gillison, M. L., Harrington, K. J., Le, Q.-T., Lee, N. Y., Leidner, R., Lewis, R. L., Licitra, L., Mehanna, H., Mell, L. K., Raben, A., Sikora, A. G., Uppaluri, R., Whitworth, F., Zandberg, D. P., & Ferris, R. L.
Venue
Journal for ImmunoTherapy of Cancer
Publisher
BMJ
Published
2019-07-15
Volume
7
Issue
1
Pages
184-184
ISSN
2051-1426 (ISSN-L)
DOI
10.1186/s40425-019-0662-5
OpenAlex
W2958648554
Cited by
722
References
132
FWCI
30.65
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). https://app.cochat.ai/papers/10.1186/s40425-019-0662-5
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Cohen, E. E. W., Bell, R. B., Bifulco, C. B., Burtness, B., Gillison, M. L., Harrington, K. J., Le, Q.-T., Lee, N. Y., Leidner, R., Lewis, R. L., Licitra, L., Mehanna, H., Mell, L. K., Raben, A., Sikora, A. G., Uppaluri, R., Whitworth, F., Zandberg, D. P., & Ferris, R. L. (2019). The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of squamous cell carcinoma of the head and neck (HNSCC). Journal for ImmunoTherapy of Cancer. https://doi.org/10.1186/s40425-019-0662-5

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.