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Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer’s disease detection

Vimbi, Viswan, Shaffi, Noushath, Mahmud, Mufti·2024·Brain Informatics
DOI 10.1186/s40708-024-00222-1
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Abstract

Explainable artificial intelligence (XAI) has gained much interest in recent years for its ability to explain the complex decision-making process of machine learning (ML) and deep learning (DL) models. The Local Interpretable Model-agnostic Explanations (LIME) and Shaply Additive exPlanation (SHAP) frameworks have grown as popular interpretive tools for ML and DL models. This article provides a systematic review of the application of LIME and SHAP in interpreting the detection of Alzheimer’s disease (AD). Adhering to PRISMA and Kitchenham’s guidelines, we identified 23 relevant articles and investigated these frameworks’ prospective capabilities, benefits, and challenges in depth. The results emphasise XAI’s crucial role in strengthening the trustworthiness of AI-based AD predictions. This review aims to provide fundamental capabilities of LIME and SHAP XAI frameworks in enhancing fidelity within clinical decision support systems for AD prognosis.

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Metadata

Authors
Vimbi, V., Shaffi, N., & Mahmud, M.
Venue
Brain Informatics
Publisher
Springer Science and Business Media LLC
Published
2024-04-05
Volume
11
Issue
1
ISSN
  • 2198-4018
  • 2198-4026
DOI
10.1186/s40708-024-00222-1
Cited by
433
References
7
Language
en
Licence
Funders
  • Ministry of Higher Education, Research and Innovation (MoHERI/BFP/UoTAS/01/2021)
  • Nottingham Trent University (QR Grant 2023)
  • HORIZON EUROPE Framework Programme (101095384)

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CoChat. (2026). Citation check: Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer’s disease detection. https://app.cochat.ai/papers/10.1186/s40708-024-00222-1
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Vimbi, V., Shaffi, N., & Mahmud, M. (2024). Interpreting artificial intelligence models: a systematic review on the application of LIME and SHAP in Alzheimer’s disease detection. Brain Informatics. https://doi.org/10.1186/s40708-024-00222-1