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Cited by 117Intestinal and Peritoneal AdhesionsSurgical Sutures and AdhesivesHernia repair and management

Battling adhesions: from understanding to prevention

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Capella-Monsonís, Héctor, Kearns, Stephen, Kelly, Jack, Zeugolis, Dimitrios I.·2019·BMC Biomedical Engineering
DOI 10.1186/s42490-019-0005-0PMC PMC7412649
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Abstract

Adhesions represent a major burden in clinical practice, particularly following abdominal, intrauterine, pericardial and tendon surgical procedures. Adhesions are initiated by a disruption in the epithelial or mesothelial layer of tissue, which leads to fibrin adhesion sites due to the downregulation of fibrinolytic activity and an increase in fibrin deposition. Hence, the metabolic events involved in tissue healing, coagulation, inflammation, fibrinolysis and angiogenesis play a pivotal role in adhesion formation. Understanding these events, their interactions and their influence on the development of post-surgical adhesion is crucial for the development of effective therapies to prevent them. Mechanical barriers, antiadhesive agents and combination thereof are customarily used in the battle against adhesions. Although these systems seem to be effective at reducing adhesions in clinical procedures, their prevention remains still elusive, imposing the need for new antiadhesive strategies.

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  • The immune response to an implanted biomaterial is initiated by inflammation caused by surgery itself.

    “The immune response to an implanted biomaterial is initiated by the inflammation caused by surgery itself.”

    From Immune Response to Extracellular Matrix Bioscaffolds: A Comprehensive Review (2025) · cites this paper as [6]

    The ‘Inflammatory response and coagulation mechanism’ section says surgery can disrupt tissue, followed by immune-cell infiltration and inflammation. It describes post-surgical adhesion formation, however, not the initiation of an immune response specifically to an implanted biomaterial. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

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References 129 · Cited by 117

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Authors
Capella-Monsonís, H., Kearns, S., Kelly, J., & Zeugolis, D. I.
Affiliations
  • University Hospital Galway (IE)
  • Science Foundation Ireland (IE)
Corresponding author
Zeugolis, Dimitrios I.
ORCID
Venue
BMC Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Published
2019-02-27
Volume
1
Issue
1
Pages
5-5
ISSN
2524-4426 (ISSN-L)
DOI
10.1186/s42490-019-0005-0
PMC
PMC7412649
OpenAlex
W2928048029
Cited by
117
References
129
Citations by year
2026: 16 · 2025: 25 · 2024: 24 · 2023: 15 · 2022: 18 · 2021: 11 · 2020: 6 · 2019: 1
FWCI
1.86
Type
journal article
Language
en
Open access
Licence
Locations
  • BMC Biomedical Engineering (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Science Foundation Ireland (15/CDA/3629, 13/RC/2073)
Topics
  • Health Sciences › Medicine › Surgery › Intestinal and Peritoneal Adhesions
  • Health Sciences › Medicine › Surgery › Surgical Sutures and Adhesives
  • Health Sciences › Medicine › Surgery › Hernia repair and management
Keywords
surgical adhesions, postoperative adhesions, anti-adhesion barrier, fibrin deposition, fibrinolysis, tissue repair, coagulation, inflammation, angiogenesis, adhesion prevention

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