The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163
Abstract
TACE/ADAM17-mediated shedding of CD163 likely explains the empirical relationship between the sCD163 plasma level and infectious/inflammatory diseases relating to macrophage activity. CD163 is expressed specifically in the monocyte/macrophage lineage, where it mediates uptake of haptoglobin-hemoglobin complexes, leading to metabolism of the oxidative heme molecule. Shedding of the CD163 ectodomain from the cell surface produces a sCD163 plasma protein, and a positive correlation is seen between the sCD163 plasma level and the severity of various infectious and inflammatory diseases. In the present analysis of the phorbol ester-induced shedding of sCD163 in CD163 cDNA-transfected HEK293 cells, we used metalloproteinase inhibitors and siRNA-mediated inhibition of metalloproteinases to identify TACE/ADAM17 as an enzyme responsible for PMA-induced cleavage of the membrane-proximal region of CD163. As TACE/ADAM17-mediated shedding of TNF-α is up-regulated in macrophages subjected to inflammatory stimuli, the present results now provide a likely explanation for the strong empirical relationship between the sCD163 plasma level and infectious/inflammatory diseases relating to macrophage activity.
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Citations
Cites
Hepcidin—a regulator of intestinal iron absorption and iron recycling by macrophages
GANZ, T. (2005) · Best Practice & Research Clinical Haematology · doi:10.1016/j.beha.2004.08.020 · Cited by 393 · cited 1×
“The physiological role of sCD163 is unknown, but it is has been speculated [16] that its binding of haptoglobinhemoglobin suppresses heme-iron supply to hemolytic bacteria, in line with the inflammation-induced, hepcidin-controlled down-regulation of plasma-iron that may also prevent bacterial growth [17].”
Background
Cited by
ADAM17: a molecular switch to control inflammation and tissue regeneration
Scheller, J., Chalaris, A., Garbers, C., & Rose-John, S. (2011) · Trends in Immunology · doi:10.1016/j.it.2011.05.005 · Cited by 526
Schaer, D. J., & Buehler, P. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013433 · Cited by 96
Sleep apnoea, insulin resistance and diabetes: the first step is in the fat
Almendros, I., & García-Río, F. (2017) · European Respiratory Journal · doi:10.1183/13993003.00179-2017 · Cited by 34
Biomarkers of Neurological Damage: From Acute Stage to Post-Acute Sequelae of COVID-19
Zingaropoli, M. A., Pasculli, P., Barbato, C., Petrella, C., Fiore, M., Dominelli, F., Latronico, T., Ciccone, F., Antonacci, M., Liuzzi, G. M., et al. (2023) · Cells · doi:10.3390/cells12182270 · Cited by 16
Metadata
- Authors
- Etzerodt, A., Maniecki, M. B., Møller, K., Møller, H. J., & Moestrup, S. K.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-08-31
- Volume
- 88
- Issue
- 6
- Pages
- 1201-1205
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W1998747985
- Cited by
- 211
- References
- 1
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. https://app.cochat.ai/papers/10.1189/jlb.0410235
- The paper
- Etzerodt, A., Maniecki, M. B., Møller, K., Møller, H. J., & Moestrup, S. K. (2010). Tumor necrosis factor α-converting enzyme (TACE/ADAM17) mediates ectodomain shedding of the scavenger receptor CD163. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.0410235
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
