Cited by 104Neutrophil, Myeloperoxidase and Oxidative MechanismsGlycosylation and Glycoproteins ResearchBacterial biofilms and quorum sensing

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Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

Khatua, Biswajit, Bhattacharya, Kaushik, Mandal, Chitra·2012·Journal of Leukocyte Biology

DOI 10.1189/jlb.0511260

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Abstract

PA is an opportunistic pathogen that is commonly associated with severe infection in immunocompromised hosts. Siglec-9 binds with Sias by cis interaction on the neutrophil surface, thereby reducing immunological activity. However, neutrophils bind with pathogens through trans interactions of siglec-9 with Sias. Neutrophils kill invading pathogens by NETs, along with extracellular phagocytosis. Here, we report the mode of the adsorption of Sias by PA from host serum, the interaction of PA+Sias with human neutrophils, and the resulting neutrophil immunological activity. The α2–3-linked sialoglycoproteins adsorbed by PA exhibited potent binding with the soluble siglec-9-Fc chimeras, CHO-siglec-9 and siglec-9 on neutrophils. The binding between PA+Sias and neutrophils was blocked by the synthetic sialoglycan Neu5Acα2–3Galβ1–4GlcNAc, confirming the linkage-specific, Sias–siglec-9 interaction. The PA+Sias and siglec-9 interaction on neutrophils reduced the level of ROS and the release of elastase, resulting in a reduction of NETs formation, demonstrating the role of the sialoglycoproteins adsorbed by PA in the weakening of neutrophil activity. The resistance of PA+Sias to NETs was made evident by the increased survival of PA+Sias. Moreover, the decrease in PA−Sias survival demonstrated the involvement of NETs formation in the absence of the Sias–siglec-9 interaction. N-actylcysteine or sivelestat-pretreated neutrophils enhanced the survival of PA−Sias. DNAse-pretreated neutrophils did not exhibit any NETs formation, resulting in the enhanced escape of PA−Sias. Taken together, one of the survival mechanisms of PA+Sias is the diminution of innate immunity via its adsorption of sialoglycoproteins by its engagement of the inhibitory molecule siglec-9. This is possibly a general mechanism for pathogens that cannot synthesize Sias to subvert immunity.

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1 retracted

RETRACTED: Sialic acids acquired by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host‐cell recognition
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Authors: Khatua, B., Bhattacharya, K., & Mandal, C.
Affiliations: Indian Institute of Chemical Biology (IN)
Corresponding author: Mandal, Chitra
ORCID: Khatua, Biswajit
Bhattacharya, Kaushik
Mandal, Chitra
Venue: Journal of Leukocyte Biology
Publisher: Oxford University Press (OUP)
Published: 2012-04-01
Volume: 91
Issue: 4
Pages: 641-655
ISSN: 0741-5400 (ISSN-L)
1938-3673
DOI: 10.1189/jlb.0511260
OpenAlex: W2111986782
Cited by: 104
References: 54
Citations by year: 2026: 2 · 2025: 7 · 2024: 9 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 5 · 2015: 2 · 2014: 9 · 2013: 6 · 2012: 4
FWCI: 2.93
Type: journal article
Language: en
Open access: closed
Licence: academic.oup.com/pages/standard-publication-reuse-rights (vor)
Locations: Journal of Leukocyte Biology (publishedVersion)
PubMed (publishedVersion)
Funders: CSIR–Indian Institute of Chemical Biology
CSIR (IAP-0001)
Systems Biology (HCP004)
New Millennium Indian Technology Leadership Initiative (TLP-004)
Department of Biotechnology under Cancer Biology (GAP 235)
Government of India
Indian Medical Research Council
German Cancer Research Center
University of Dundee
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Keywords: Pseudomonas aeruginosa, sialic acid, sialoglycoproteins, Siglec-9, neutrophil extracellular traps, neutrophil function, bacterial survival, innate immune evasion, reactive oxygen species, neutrophil elastase, sivelestat, N-acetylcysteine, DNase, host-pathogen interaction
MeSH terms: Acetylcysteine, Adult, Animals, Cell Line, Cricetulus, Female, Glycine, Cricetinae, Humans, Immunity, Innate, Male, Neutrophils, Phagocytosis, Pseudomonas aeruginosa, Pseudomonas Infections, Sulfonamides, Antigens, CD, Serine Proteinase Inhibitors, Free Radical Scavengers, CHO Cells, Reactive Oxygen Species, Lectins, Leukosialin, Immune Evasion, Sialic Acid Binding Immunoglobulin-like Lectins

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Sialoglycoproteins adsorbed by Pseudomonas aeruginosa facilitate their survival by impeding neutrophil extracellular trap through siglec-9

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