The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages
Abstract
Discovery of the growth factor activity of ADA2. ADAs play a pivotal role in regulating the level of adenosine, a signaling molecule controlling a variety of cellular responses by binding to and activating four ADRs. Two enzymes, ADA1 and ADA2, are known to possess ADA activity in humans. Although the structure of ADA1 and its role in lymphocytic activation have been known for a long time, the structure and function of ADA2, a member of ADGF, remain enigmatic. Here, we found that ADA2 is secreted by monocytes undergoing differentiation into macrophages or DCs and that it binds to the cell surface via proteoglycans and ADRs. We demonstrate that ADA1 and ADA2 increase the rate of proliferation of monocyte-activated CD4+ T cells independently of their catalytic activity. We also show that ADA2 induces T cell-dependent differentiation of monocytes into macrophages and stimulates macrophage proliferation. Our discovery of the growth factor-like activity of ADA2 explains clinical observations and suggests that this enzyme could be used as a drug candidate to modulate the immune responses during inflammation and cancer.
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Cites
Adenosine Receptors as Therapeutic Targets
Jacobson, K. A., & Gao, Z.-G. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1983 · Cited by 1,431 · cited 1×
“that inhibits adenylyl cyclase (Gi), whereas the activation of A2A and A2B receptors causes the opposite effect by triggering a G protein that activates adenylyl cyclase (Gs) [2].”
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Cited by
Mutant Adenosine Deaminase 2 in a Polyarteritis Nodosa Vasculopathy
Navon Elkan, P., Pierce, S. B., Segel, R., Walsh, T., Barash, J., Padeh, S., Zlotogorski, A., Berkun, Y., Press, J. J., Mukamel, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1307362 · Cited by 710
An expression atlas of human primary cells: inference of gene function from coexpression networks
Mabbott, N. A., Baillie, J., Brown, H., Freeman, T. C., & Hume, D. A. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-632 · Cited by 474
When less is more: primary immunodeficiency with an autoinflammatory kick
Giannelou, A., Zhou, Q., & Kastner, D. L. (2014) · Current Opinion in Allergy & Clinical Immunology · doi:10.1097/aci.0000000000000117 · Cited by 34
Metadata
- Authors
- Zavialov, A. V., Gracia, E., Glaichenhaus, N., Franco, R., Zavialov, A. V., & Lauvau, G.
- Venue
- Journal of Leukocyte Biology
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-05-07
- Volume
- 88
- Issue
- 2
- Pages
- 279-290
- ISSN
- 0741-5400 (ISSN-L)
- 1938-3673
- OpenAlex
- W2117679109
- Cited by
- 250
- References
- 1
- FWCI
- 3.53
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zavialov, A. V., Gracia, E., Glaichenhaus, N., Franco, R., Zavialov, A. V., & Lauvau, G. (2010). Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. Journal of Leukocyte Biology. https://doi.org/10.1189/jlb.1109764
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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