Nutritional supplementation and resistance training in nutritionally at risk older adults following lower limb fracture: a randomized controlled trial
Abstract
Objective To describe the independent and combined effects of oral nutrition supplementation and resistance training on health outcomes in nutritionally at risk older adults following lower limb fracture. Design Randomized controlled trial with 12-week masked outcome assessment. Setting Teaching hospital. Participants One hundred nutritionally at risk older adults hospitalized following a fall-related lower limb fracture. Intervention Commenced seven days after injury. Consisted of daily multinutrient energy-dense oral supplement (6.3 kJ/mL) individually prescribed for six weeks (n = 25), tri-weekly resistance training for 12 weeks (n = 25), combined treatment (n = 24) or attention control plus usual care and general nutrition and exercise advice (n = 26). Measurements Weight change, quadriceps strength, gait speed, quality of life and health care utilization at completion of the 12-week intervention. Results At 12 weeks, all groups lost weight: nutrition -6.2% (-8.4, -4.0); resistance training -6.3% (-8.3, -4.3); nutrition and resistance training -4.7% (-7.4, -2.0); attention control -5.2% (-9.0, -1.5). Those receiving resistance training alone lost more weight than those receiving the combined treatment (P= 0.029). Significant weight loss was prevented if supplement was consumed for at least 35 days. Groups were no different at 12 weeks for any other outcome. Conclusion Frail, undernourished older adults with a fall-related lower limb fracture experience clinically signific…
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Four RCTs reported positive effects of oral nutritional supplementation in combination with exercise training on various outcome parameters, including body weight, MNA score, and muscle mass.
“Four of them -one in COPD patients (94), two in rehabilitation patients (95,96), one in malnourished patients with lower limb fracture (87) -reported positive effects of oral nutritional supplementation in combination with exercise training on various outcome parameters, e.g.BW (87,94,95), MNA score (95), muscle mass (95,96).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [87]
Five RCTs were identified comparing combined exercise and nutrition interventions to singular exercise interventions in older people with malnutrition or at risk of malnutrition.
“Five RCTs were identified comparing combined exercise and nutrition interventions to singular exercise interventions in older people with malnutrition or at risk of J o u r n a l P r e -p r o o f malnutrition (83,87,(94)(95)(96).”
From ESPEN practical guideline: Clinical nutrition and hydration in geriatrics (2022) · cites this paper as [87]
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- Authors
- Miller, M. D., Crotty, M., Whitehead, C., Bannerman, E., & Daniels, L. A.
- Affiliations
- Flinders University (AU)
- Venue
- Clinical Rehabilitation
- Publisher
- SAGE Publications
- Published
- 2006-04
- Volume
- 20
- Issue
- 4
- Pages
- 311-323
- ISSN
- 0269-2155 (ISSN-L)
- 1477-0873
- OpenAlex
- W2123133561
- Cited by
- 92
- References
- 63
- Citations by year
- 2026: 7 · 2025: 4 · 2024: 1 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 3 · 2013: 3 · 2012: 9
- FWCI
- 2.87
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Clinical Rehabilitation (publishedVersion)
- PubMed (publishedVersion)
- Queen Margaret University Publications Repository (Queen Margaret University) (acceptedVersion)
- Flinders Academic Commons (Flinders University) (submittedVersion)
- Queen Margaret University Publications Repository (Queen Margaret University) (submittedVersion)
- Funders
- Flinders University
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Surgery › Hip and Femur Fractures
- Health Sciences › Nursing › Nutrition and Dietetics › Clinical Nutrition and Gastroenterology
- Keywords
- oral nutritional supplementation, resistance training, older adults, lower limb fractures, weight loss, frailty, malnutrition, fall-related fractures, quadriceps strength, walking speed, quality of life, nutritional status
- MeSH terms
- Aged, 80 and over, Female, Humans, Leg Injuries, Male, Nutritional Status, Quality of Life, Weight Loss, Frail Elderly, Nutritional Support, Physical Therapy Modalities, Fractures, Bone
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