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Cited by 15Occupational and environmental lung diseasesInterstitial Lung Diseases and Idiopathic Pulmonary FibrosisOccupational Health and Global Justice

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

An assessment of asbestos body formation in extrapulmonary sites: liver and spleen

Williams, Marion Glenn, Dodson, Ronald F, Dickson, Eric W, Fraire, Armando E·2001·Toxicology and Industrial Health
DOI 10.1191/0748233701th090oa
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Abstract

Study Objectives: Asbestos bodies (ABs) form as asbestos fibers become coated by a cellular iron- and protein-rich matrix. ABs have been reported in lymph nodes and a few extrapulmonary sites, but no data exist as to their formation outside of the lung. It is not clear whether the AB found in these extrapulmonary areas have been transported as mature structures from the lung or formed at the extrapulmonary site. This study was designed to determine if ABs are produced in extrapulmonary sites. The guinea pig efficiently forms ferruginous bodies in the lung and so it was chosen as a model to test the coating efficiency of amosite asbestos fibers in lung, liver and spleen. Design: Sized amosite asbestos (5 mg) was administered either endotracheally into lung (n=2) or directly into liver (n=4) and spleen (n=4) of healthy 10-week-old male guinea pigs. The lung, liver and splenic tissues were removed at 40 and 180 days post inoculation and were examined histologically for the presence of AB via light microscopy. Uncoated fibers isolated from the tissues were characterized by electron microscopy. The coating efficiency was calculated as a ratio of uncoated/coated fibers per organ. Results: The coating efficiency ratios of fibers that were collected at 40 days post-injection from the individual sites were: lung—350:1, liver—4200:1, and spleen—220,000:1. At 6 months post-injection the ratios for the individual sites consisted of: lung—176:1, liver—11,000:1, and spleen—1000:1. Conclusion: This study indicates that AB can be formed in extrapulmonary sites and that the coating efficiency in the lung is much greater than that within the liver or spleen.

Overview

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Registry

Crossref · 10.1191/0748233701th090oa

Cites

28 of 28 references verified0 citation errors · 0 not checkable

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Claims the paper makes

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Citations

Cites

Research works printed but not linked: 9

  1. Craighead, J. E., 1982, Archives of Pathology and Laboratory Medicine, 106, 544
  2. Davis, J. M. G., 1964, British Journal of Experimental Pathology, 45, 642
  3. Davis, J. M. G., 1964, British Journal of Experimental Pathology, 45, 634
  4. Davis, J. M. G., 1970, Archives of Pathology, 89, 364
  5. Dodson, R. F., 1985, American Review of Respiratory Disease, 132, 143
  6. Gross, P., 1968, Archives of Pathology, 85, 539
  7. Marchand, F., 1906, Verhandlungen der Deutschen Gesellschaft fuer Pathologie, 17, 223
  8. Roggli, V. L., 1990, Modern Pathology, 3, 513
  9. Zaidi, S. H. 1969: Silicatosis and the effect of mixed dust. Experimental pneumonocosis. The Johns Hopkins Press, Baltimore, MD, Chapter 8, 144-164.

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Metadata

Authors
Williams, M. G., Dodson, R. F., Dickson, E. W., & Fraire, A. E.
Affiliations
  • The University of Texas Health Science Center at Tyler (US)
  • University of Massachusetts Chan Medical School (US)
Corresponding author
Dodson, Ronald F
Venue
Toxicology and Industrial Health
Publisher
SAGE Publications
Published
2001-02
Volume
17
Issue
1
Pages
1-6
ISSN
  • 0748-2337 (ISSN-L)
  • 1477-0393
DOI
10.1191/0748233701th090oa
OpenAlex
W2013644957
Cited by
15
References
28
Citations by year
2021: 1 · 2017: 3 · 2016: 2 · 2015: 1 · 2012: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Licence
journals.sagepub.com/page/policies/text-and-data-mining-license (tdm)
Locations
  • Toxicology and Industrial Health (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Occupational and environmental lung diseases
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Social Sciences › Health › Occupational Health and Global Justice
Keywords
asbestos bodies, ferruginous bodies, liver, spleen, guinea pig model
MeSH terms
Animals, Asbestosis, Disease Models, Animal, Ferritins, Foreign Bodies, Guinea Pigs, Liver, Lung, Male, Spleen, Asbestos, Amosite, Mineral Fibers

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.